2016-2020 Publications

  1. Kim, Hyun; Rogler, Patrick J.; Sharma, Savita K.; Schaefer, Andrew W.; Solomon, Edward I.; Karlin, Kenneth D. “Heme-FeIII Superoxide, Peroxide and Hydroperoxide Thermodynamic Relationships: FeIII-O2•– Complex H-Atom Abstraction Reactivity” J. Am. Chem. Soc. 2020, 142, 3104-3116, doi.org/10.1021/jacs.9b12571. PMCID: PMC7034651
  1. Lim, H.; Baker, M. L.; Cowley, R. E.; Kim, S.; Bhadra, M.; Siegler, M. A.; Kroll, T.; Sokaras, D.; Weng, T.-C.; Biswas, D. R.; Dooley, D. M.; Karlin, K. D.; Hedman, B.; Hodgson, K. O.; Solomon, E. I. Kβ X-ray Emission Spectroscopy as a Probe of Cu(I) Sites: Application to the Cu(I) Site in Preprocessed Galactose Oxidase Inorg. Chem. 2020, 59, 16567-16581. https://dx.doi.org/10.1021/acs.inorgchem.0c02495. PMCID: PMC7799175.
  1. Diaz, Daniel E.; Quist, David A.; Herzog, Austin E.; Schaefer, Andrew W.; Kipouros, I.; Bhadra, Mayukh; Solomon, Edward I.; Karlin, Kenneth D. “Impact of Intramolecular Hydrogen Bonding on the Reactivity of Cupric Superoxide Complexes with O–H and C–H Substrates” Angew. Chem. Int. Ed., 2019, 58, 17572 –17576. https://dx.doi.org/10.1002/anie.201908471.  PMCID: PMC6878127
  1. Wijeratne, Gayan B.; Bhadra, Mayukh; Siegler, Maxime A.; Karlin, Kenneth D. “Copper(I) Complex Mediated Nitric Oxide Reductive Coupling: Ligand Hydrogen Bonding Derived Proton Transfer Promotes N2O(g) Release” J. Am. Chem. Soc. 2019, 141, 17962-17967. https://dx.doi.org/10.1021/jacs.9b07286. PMCID: PMC6896986
  1. Kim, Hyun; Sharma, Savita K.; Schaefer, Andrew W.; Solomon, Edward I.; Karlin, Kenneth D. “Heme–Cu Binucleating Ligand Supports Heme/O2 and FeII­–CuI/O2 Reactivity Providing High- and Low-Spin FeIII–Peroxo-CuIIComplexes”. Inorg. Chem., 2019, 58, 15423-15432. https://dx.doi.org/10.1021/acs.inorgchem.9b02521. PMCID: PMC6916717
  1. Diaz, Daniel; Bhadra, Mayukh; Karlin, Kenneth D. “Dimethylanilinic N‑Oxides and Their Oxygen Surrogacy Role in the Formation of a Putative High-Valent Copper−Oxygen Species”, Inorg. Chem. 2019, 58, 13746-13750. https://doi.org/10.1021/acs.inorgchem.9b02066. PMCID: PMC6896993
  1. Quist, David. A.; Ehudin, Melanie A.; Schaefer, Andrew W.; Schneider, Gregory L.; Solomon, Edward I.; Karlin, Kenneth D. “Ligand Identity-Induced Generation of Enhanced Oxidative Hydrogen Atom Transfer Reactivity for a CuII2(O2•−) Complex Driven by Formation of a CuII2(OOH) Compound with a Strong O−H Bond”. J. Am. Chem. Soc. 2019, 141, 12682-12696.   https://doi.org/10.1021/jacs.9b05277. PMCID: PMC6752211
  1. Ehudin, Melanie, A.; Quist, David A.; Karlin, Kenneth D. “Enhanced Rates of C−H Bond Cleavage by a Hydrogen-Bonded Synthetic Heme High-Valent Iron(IV) Oxo Complex” J. Am. Chem. Soc. 2019, 141, 12558-12569. https://doi.org/10.1021/jacs.9b01253. PMCID: PMC6734939
  1. Liu, Jeffrey J.; Siegler, Maxime A.; Karlin, Kenneth D.; Moenne-Loccoz, P. “Direct Resonance Raman Characterization of a Peroxynitrito Copper Complex Generated from O2 and NO and Mechanistic Insights into Metal Mediated Peroxynitrite Decomposition” Angew. Chem. Int. Ed., 2019, 58, 10936–10940. https://doi.org/10.1002/anie.201904672. PMCID: PMC6685550
  1. Ehudin Melanie, A.; Senft, L.; Franke, Alicja; Ivanović-Burmazović, Ivana; Karlin, Kenneth D. “Formation and Reactivity of New Isoporphyrins: Implications for Understanding the Tyr-His Cross-Link Cofactor Biogenesis in Cytochrome c Oxidase” J. Am. Chem. Soc. 2019, 141, 10632−10643. https://doi.org/10.1021/jacs.9b01791. PMCID: PMC6639807
  1. Ehudin; Melanie, A.; Gee, Leland B.; Sabuncu, Sinan; Braun, Augustin; Moënne-Loccoz, Pierre; Hedman, Britt; Hodgson Keith O.; Solomon, Edward I.; Karlin, Kenneth D. “Tuning the Geometric and Electronic Structure of Synthetic High-Valent Iron(IV)-Oxo Models in the Presence of a Lewis Acid and Various Axial Ligands.” J. Am. Chem. Soc. 2019, 141, 5942-5960. https://doi.org/10.1021/jacs.9b00795.  PMCID: PMC6611672
  1. Schaefer, Andrew W.; Ehudin, Melanie A.; Quist, David A.; Tang, Joel A.; Karlin, Kenneth D.; Solomon, Edward I. “Spin Interconversion of Heme-Peroxo-Copper Complexes Facilitated by Intramolecular Hydrogen-Bonding Interactions” J. Am. Chem. Soc. 2019, 141, 4936–4951. https://doi.org/10.1021/jacs.9b00118. PMCID: PMC6457345
  1. Ehudin, Melanie A.; Schaefer, Andrew W.; Adam, Suzanne M.; Quist, David A.; Diaz, Daniel E.; Tang, Joel A.; Solomon, Edward I.; Karlin, Kenneth D. “Influence of Intramolecular Secondary Sphere Hydrogen-Bonding Interactions on Cytochrome c Oxidase Inspired Low-Spin Heme-Peroxo-Copper Complexes” Chemical Science, 2019, 10, 2893–2905. https://doi.org/10.1039/C8SC05165H. Edge Article. PMCID: PMC6431958
  1. Quist, David A.; Ehudin, Melanie A.; Karlin, Kenneth D. “Unprecedented Direct Cupric-Superoxo Conversion to a Bis-μ-oxo Dicopper(III) Complex and Resulting Oxidative Activity” Inorg. Chim. Acta 2019, 485, 155-161. https://dx.doi.org/10.1016/j.ica.2018.10.015. PMCID: PMC6461407
  1. Adam, Suzanne M.; Wijeratne, Gayan B.; Rogler, Patrick J.; Diaz, Daniel E.; Quist, David A.; Liu, Jeffrey J.; Karlin, Kenneth D.“Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function” Chemical Reviews, 2018, 118, 10840−11022, https://dx.doi.org/10.1021/acs.chemrev.8b00074. PMCID: PMC6360144
  1. Hong, Seungwoo; Yan, James J.; Karmalkar, Deepika, G.; Sutherlin, Kyle D.; Kim, Jin; Lee, Yong-Min; Goo, Yire; Mascharak, Pradip K.; Hedman, Britt; Hodgson, Keith O.; Karlin, Kenneth D.; Solomon, Edward I.; Nam, Wonwoo “A mononuclear nonheme {FeNO}6 complex: Synthesis and structural and spectroscopic characterization”, Chem. Sci. 20189, 6952–6960. https://dx.doi.org/10.1039/c8sc01962b. PMCID: PMC6124912
  1. Bhadra, M.; Lee, J. Y. C.; Cowley, R. E.; Kim, S.; Siegler, M. A.; Solomon, E. I.; Karlin, K. D. “Intramolecular Hydrogen Bonding Enhances Stability and Reactivity of Mononuclear Cupric Superoxide Complexes” J. Am. Chem. Soc. 2018, 140, 9042-9045. https://dx.doi.org/10.1021/jacs.8b04671. PMCID: PMC6217813
  1. López, Isidoro; Cao, Rui, Quist, David A.; Karlin, Kenneth D; Le Poul, Nicolas, “Direct Determination of Electron-Transfer Properties of Dicopper-Bound Reduced Dioxygen Species by a Cryo-Spectroelectrochemical Approach” Chem. Eur. J. 2017, 23, 18314-18319. https://dx.doi.org/10.1002/chem.201705066. PMCID: PMC5783699
  1. Sharma, Savita K.; Schaefer, Andrew W.; Lim, Hyeongtaek; Matsumura, Hirotoshi; Moënne-Loccoz, Pierre; Hedman, Britt; Hodgson, Keith O.; Solomon, Edward I.; Karlin, Kenneth D. “A Six-Coordinate Peroxynitrite Low-Spin Iron(III) Porphyrinate Complex—The Product of the Reaction of Nitrogen Monoxide (·NO(g)) with a Ferric-Superoxide Species” J. Am. Chem. Soc. 2017, 139, 17421-17430. https://dx.doi.org/10.1021/jacs.7b08468. PMCID: PMC5783694
  1. Wijeratne, Gayan, B.; Hematian, Shabnam; Siegler, Maxime A.: Karlin, Kenneth D., “Copper(I)NO(g) Reductive Coupling Producing a trans-Hyponitrite Bridged Dicopper(II) Complex – Redox Reversal Giving Copper(I) / NO(g)Disproportionation”., J. Am. Chem. Soc. 2017, 139, 13276-13279. https://dx.doi.org/10.1021/jacs.7b07808. PMCID: PMC5630263
  1. Schaefer, Andrew W.; Kieber-Emmons, Matthew T.; Adam, Suzanne M.; Karlin, Kenneth D.; Solomon, Edward I., “Phenol-Induced O−O Bond Cleavage in a Low-Spin Heme−Peroxo−Copper Complex: Implications for O2 Reduction in Heme−Copper Oxidases”, J. Am. Chem. Soc. 2017, 139, 7958-7973. https://dx.doi.org/10.1021/jacs.7b03292.  PMCID: PMC5605297
  1. Garcia-Bosch, Isaac; Cowley, Ryan E.; Diaz, Daniel E.; Peterson, Ryan L.; Solomon, Edward I.; Karlin, Kenneth D. “Substrate and Lewis Acid Coordination Promote O−O Bond Cleavage of an Unreactive L2CuII2(O22–)2 Species to Form Cores L2CuIII2(O)2 with Enhanced Oxidative Reactivity.” J. Am. Chem. Soc. 2017, 139, 3186−3195. https://dx.doi.org/10.1021/jacs.6b12990. PMCID: PMC5532877
  1. Quist, David A.; Diaz, Daniel E.; Liu, Jeffrey J.; Karlin, Kenneth D. “Activation of dioxygen by copper metalloproteins and insights from model complexes J. Biol. Inorg. Chem. (JBIC) 2017, 22, 253-288.https://dx.doi.org/10.1007/s00775-016-1415-2.  PMCID: PMC5600896
  1. Adam, Suzanne M.; Garcia-Bosch, Isaac; Schaefer, Andrew W.; Sharma, Savita K.; Siegler, Maxime A; Solomon, Edward I.; Karlin, Kenneth D., “Critical Aspects of Heme­–Peroxo–Cu Complex Structure and Nature of Proton Source Dictate Metal–Operoxo Breakage versus Reductive O–O Cleavage Chemistry”, J. Am. Chem. Soc. 2017, 139, 472−481. https://dx.doi.org/10.1021/jacs.6b11322. PMCID: PMC5274545
  1. Cao, Rui; Elrod, Lee Taylor, Lehane, Ryan L.; Kim, Eunsuk; Karlin, Kenneth D. “A Peroxynitrite Dicopper Complex: Formation via Cu–NO and Cu–O2 Intermediates and Reactivity via O–O Cleavage Chemistry” J. Am. Chem. Soc. 2016, 138, 16148−16158. https://dx.doi.org/10.1021/jacs.6b10689. PMCID: PMC5293595 
  1. Liu, Jeffrey J.; Diaz, Daniel E.; Quist, David A.; Karlin, Kenneth D. “Copper(I)-Dioxygen Adducts and Copper Enzyme Mechanisms”. Israel J. Chem., 2016, 56, 738-755. https://dx.doi.org/10.1002/ijch.201600025. PMCID:PMC5125784
  • Karlin, Kenneth D. Book Review of: “Peter M.H. Kroneck, Martha E. Sosa Torres (Guest editors), “Sustaining Life on Planet Earth: Metalloenzymes Mastering Dioxygen and Other Chewy Gases”, A. Sigel, H. Sigel, R.K.O. Sigel (Series editors), Metal Ions in Life Sciences, vol. 15, Springer International Publishing AG, Switzerland, 2015, 329 pp [ISSN 1559-0836; ISSN 1868-0402 (electronic); ISBN 978-3-319-12414-8; ISBN 978-3-319-12415-5 (eBook), http://dx.doi.org/10.1007/978-3-319-12415-5,  Inorg. Chim. Acta 2016, 451, 207-208.
  1. Hong, S.; Kumar, P.; Cho, K.-B.; Lee, Y.-M.; Karlin, K. D.; Nam, W. “Mechanistic Insight into the Nitric Oxide Dioxygenation Reaction of Nonheme Iron(III)–Superoxo and Manganese(IV)–Peroxo Complexes” Angew. Chem. Intl. Ed. 2016, 55, 12403-12407. https://dx.doi.org/10.1002/anie.201605705. PMCID: PMC5042135
  1. Sharma, Savita K.; Kim, Hyun; Rogler, Patrick J.; Siegler, Maxime, A.; Karlin, Kenneth D. “Isocyanide or nitrosyl complexation to hemes with varying tethered axial base ligand donors: synthesis and characterization”. J. Biol. Inorg. Chem., 2016 21, 729-743. https://dx.doi.org/10.1007/s00775-016-1369-4. PMCID: PMC5003086
  1. Kumar, P.; Lee, Y.-M.; Hu, L.; Chen, J.; Park, Y. J.; Yao, J.; Chen, H.; Karlin, K. D.; Nam, W. “Factors That Control the Reactivity of Cobalt(III)–Nitrosyl Complexes in Nitric Oxide Transfer and Dioxygenation Reactions: A Combined Experimental and Theoretical Investigation”. J. Am. Chem. Soc. 2016, 138, 7753-7762. https://dx.doi.org/10.1021/jacs.6b04040. PMCID: PMC4951108
  1. Cao, Rui.; Saracini, Claudio; Ginsbach, Jake W.; Kieber-Emmons, Matthew T.; Siegler, Maxime A.; Solomon, Edward I.; Fukuzumi, Shunichi; Karlin, Kenneth D. “Peroxo and Superoxo Moieties Bound to Copper Ion: Electron-Transfer Equilibrium with a Small Reorganization Energy”. J. Am. Chem. Soc. 2016, 138, 7055-7066. https://dx.doi.org/10.1021/jacs.6b02404. PMCID: PMC4950875
  1. Garcia-Bosch, Isaac; Cowley, Ryan E.; Diaz, Daniel E.; Siegler, Maxime A. Siegler; Nam, Wonwoo Nam; Solomon, Edward I.; Karlin, Kenneth D. “Dioxygen Activation by a Macrocyclic Copper Complex Leads to a Cu2O2Core with Unexpected Structure and Reactivity”, Chem. Eur. J., 2016, 22, 5133-5137. https://dx.doi.org/10.1002/chem.201600551  PMCID: PMC4852750
  1. Yamada, Mihoko; Karlin, Kenneth D.; Fukuzumi, Shunichi, “One-step selective hydroxylation of benzene to phenol with hydrogen peroxide catalysed by copper complexes incorporated into mesoporous silica–alumina”, Chem. Sci., 2016, 7, 2856-2863. https://dx.doi.org/10.1039/C5SC04312C. PMCID: PMC4951108