Lukas M, Parkins S, Severin D, Grier BD, Ewall G, Kotha S, Wesselborg C, Moreno C, Jaoui Y, Felder A, Huang B, Johnson MB, Harrigan TP, Knight AE, Lani SW, Lemaire T, Kirkwood A, Hwang GM, and Lee H-K. (2024) Transcranial low-intensity focused ultrasound (LIFU) stimulation of the visual thalamus produces long-term depression of thalamocortical synapses in the adult visual cortex. Journal of Neuroscience. Online ahead of publication; Data files (Mendeley Data)

Grier BD, Parkins S, Omar J, and Lee H-K. (2023) Selective plasticity of fast and slow excitatory synapses on somatostatin interneurons in adult visual cortex. Nature Communications 14: 7165. Web access; Data files (Mendeley Data)

Mesik L and Lee H-K. (2023) Cross-modal plasticity of cortical and thalamic circuits. In: The Cerebral Cortex and Thalamus (Editors: Usrey WM and Sherman SM; Section Editor: Chen C). Oxford Press. Web page

Araki Y, Gerber EE, Rajkovich KE, Hong I, Johnson RC, Lee H-K, Kirkwood A, and Huganir RL. (2023) Mouse models of SYNGAP1-related intellectual disability. Proceedings of the National Academy of Sciences USA 120: e2308891120. View PDF file

Valdivia G, Ardiles AO, Idowu A, Salazar C, Lee H-K, Gallagher M, Palacios AG, and Kirkwood A. (2023) mGluR-dependent plasticity in rodent models of Alzheimer’s disease. Frontiers in Synaptic Neuroscience 15: 1123294. Web access

Lee H-K. (2023) Metaplasticity framework for cross-modal synaptic plasticity in adults. Frontiers in Synaptic Neuroscience 14: 1087042. Web access

Whitt JL*, Ewall G*, Chakraborty D, Adegbesan A, Lee R, Kanold PO, and Lee H-K. (2022) Visual deprivation selectively reduces thalamic reticular nucleus-mediated inhibition of the auditory thalamus in adults. Journal of Neuroscience 42(42): 7921-7930. View PDF file; Data files (Mendeley Data)

Hong SZ, Mesik L, Grossman CD, Cohen JY, Lee B, Lee H-K, Hell JW, and Kirkwood A. (2022) Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces. Nature Communications 13: 3102. Web access

Kim Y-H, Schrode KM, Engel J, Vicencio-Jimenez S, Rodriguez G, Lee H-K, and Lauer AM. (2022) Auditory behavior in adult-blinded mice. Journal of the Association for Research in Otolaryngology 32: 225-239. View PDF file

Ewall G*, Parkins S*, Lin A, Jaoui Y, and Lee H-K. (2021) Cortical and subcortical circuits for cross-modal plasticity induced by loss of vision. Frontiers in Neural Circuits 15: 665009. Web access

Chokshi V*, Grier BD*, Dykman A, Lantz CL, Niebur E, Quinlan EM, and Lee H-K. (2021) Naturalistic spike trains drive state-dependent homeostatic plasticity in superficial layers of visual cortex. Frontiers in Synaptic Neuroscience. 13: 663282. Web access; Analysis files (GitHub)

Lee H-K and Kirkwood A. (2019) Mechanisms of homeostatic synaptic plasticity in vivoFrontiers in Cellular Neuroscience 13: 520. View PDF file

Solarana K, Liu J, Bowen Z, Lee H-K, and Kanold PO. (2019) Temporary visual deprivation causes decorrelation of spatiotemporal population responses in adult auditory cortex. eNeuro 6: 1-13. View PDF file (reduced size)

Chokshi V, Gao M, Grier BD, Owens A, Wang H, Worley PF, and Lee H-K. (2019) Input-specific metaplasticity in the visual cortex requires Homer1a-mediated mGluR5 signaling. Neuron 104: 736-748. View PDF file (reduced size)Data files (Mendeley Data)

Rodriguez G, Mesik L, Gao M, Parkins S, Saha R, and Lee H-K. (2019) Disruption of NMDAR function prevents normal experience-dependent homeostatic synaptic plasticity in mouse primary visual cortex. Journal of Neuroscience 39: 7664-7673. View PDF file

Chokshi V, Druciak B, Worley PF, Lee H-K. (2019) Homer1a is required for establishment of contralateral bias and maintenance of ocular dominance in mouse visual cortex. Journal of Neuroscience 39 (20): 3897-3905. View PDF file

Fernandes D, Santos SD, Coutinho E, Whitt JL, Beltrão N, Rondão T, Leite MI, Buckley C, Lee H-K, Carvalho AL. (2019) Distrupted AMPA receptor function upon genetic- or antibody-mediated loss of autism-associated CASPR2. Cerebral Cortex 2019: 1-13. View PDF file

Rodriguez G, Chakraborty D, Schrode KM, Saha R, Uribe I, Lauer AM, and Lee H-K. (2018) Cross-modal reinstatement of thalamocortical plasticity accelerates ocular dominance plasticity in adult mice. Cell Reports 24: 3433-3440. View PDF fileData files (Mendeley Data)

Bridi MCD, de Pasquale R, Lantz CL, Gu Y, Borrell A, Choi S-Y, He K, Tran T, Hong SZ, Dykman A, Lee H-K, Quinlan E, and Kirkwood A. (2018) Two distinct mechanisms for experience-dependent homeostasis. Nature Neuroscience 21: 843-850. View article and Supplementary files

Meng X, Kao JPY, Lee H-K, and Kanold PO. (2017) Intracortical circuits in thalamorecipient layers of auditory cortex refine after visual deprivation. eNeuro 0092-17. View PDF file

Keck T, Toyoizumi T, Chen L, Boiron B, Feldman DE, Fox K, Gerstner W, Haydon PG, Hubener M, Lee H-K, Lisman JE, Rose T, Sengpiel F, Stellwagen D, Stryker MP, Turrigiano GG, and van Rossum MC. (2017) Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philosophical Transactions of the Royal Society B. 372 (1715): 20160158. View PDF file

Gao M*, Whitt JL*, Huang S*, Lee A, Mihalas S, Kirkwood A, and Lee H-K. (2017) Experience-dependent homeostasis of “noise” at inhibitory synapses preserves information coding in adult visual cortex. Philosophical Transactions of the Royal Society B. 372 (1715): 20160156. View PDF file

Lee H-K. (2016) Talk louder so I can see you. Neuron 89: 887-888. View PDF file

Lee H-K and Whitt JL. (2015) Cross-modal synaptic plasticity in adult primary sensory cortices. Current Opinion in Neurobiology 74 (3): 119-126. View PDF file

Meng X, Kao JPY, Lee H-K, and Kanold PO. (2015) Visual deprivation causes refinement of intracortical circuits in the auditory cortex. Cell Reports 12 (6): 955-964. View PDF file

Megill A, Tran T, Eldred K, Lee NJ, Wong PC, Hoe H-S, Kirkwood A, and Lee H-K. (2015) Defective age-dependent metaplasticity in a mouse model of Alzheimer’s disease. Journal of Neuroscience 35 (32): 11346-11357View PDF file

Petrus E, Rodriguez G, Patterson R, Connor B, Kanold PO, and Lee H-K. (2015) Vision loss shifts the balance of feedforward and intracortical circuits in opposite directions in mouse primary auditory and visual cortices. Journal of Neuroscience 35 (23): 8790-8801. View PDF file

Gao M, Maynard KR, Chokshi V, Song L, Jacobs C, Wang H, Tran T, Martinowich K, and Lee H-K. (2014) Rebound potentiation of inhibition in juvenile visual cortex requires vision-induced BDNF expression. Journal of Neuroscience 34(32): 10770-10779. View PDF file

Huang S, Rozas C, Trevino M, Contreras J, Yang S, Song L, Yoshioka T, Lee H-K, and Kirkwood A. (2014) Associative Hebbian synaptic plasticity in primate visual cortex. Journal of Neuroscience 34 (22): 7575-7579. View PDF file

Petrus E and Lee H-K. (2014) BACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortex. Neural Plasticity 2014: 128631. Web Access

Wang H, Megill A, Wong PC, Kirkwood A, and Lee H-K. (2014) Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice. PLoS One 9 (30): e92279. Web Access

Petrus E*, Isaiah A*, Jones AP, Li D, Wang H, Lee H-K, and Kanold PO. (2014) Cross-modal induction of thalamocortical potentiation leads to enhanced information processing in the auditory cortex. Neuron 81: 664-673. View PDF file and Supplementary file

Whitt JL*, Petrus E*, and Lee H-K. (2014) Experience-dependent homeostatic synaptic plasticity in neocortex. Neuropharmacology 78 (2014): 45-54. View PDF file

Song JM*, DiBattista AM*, Sung YM, Ahn JM, Turner RS, Yang J, Pak DTS, Lee H-K, and Hoe H-S. (2014) A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer’s disease. Experimental Neurology 252 (2014): 105-113. View PDF file

Ikar T, Guo N, He K, Besnard AS, Ievenson S, Hill A, Lee H-K, Hen R, Xu X, and Sahay A. (2013) Adult neurogenesis modulates excitability of the dentate gyrus. Frontiers in Neural Circuits 4: 204. View PDF file

Yang S, Megill A, Ardiles A, Ransom S, Tran T, Koh MT, Lee H-K, Gallagher M, and Kirkwood A. (2013) Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats. Journal of Neuroscience 33 (31): 12670-12678. View PDF file

Megill A*, Lee T*, DiBattista AM, Song JM, Spitzer MH, Rubenshtein M, Habib LK, Capule CC, Mayer M, Turner RS, Kirkwood A, Yang J, Pak DTS, Lee H-K, and Hoe H-S. (2013) A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras mediated spinogenesis. Journal of Neuroscience 33 (22): 9306-9318View PDF file

Cai X, Kallarackal AJ, Kvarta MD, Goluskin S, Gaylor K, Bailey AM, Lee H-K, Huganir RL, and Thompson SM. (2013) Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression. Nature Neuroscience 16 (4): 464-472. View PDF file

LeGates T, Altimus C, Wang H, Lee H-K, Yang S, Zhao H, Kirkwood A, Weber T, and Hattar S. (2012) Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature 491 (7425): 594-598View PDF file

Guo Y, Huang S, de Pascuale R, McGehrin K, Lee H-K, Zhao K, and Kirkwood A. (2012) Dark exposure extends the integration window for spike-timing dependent plasticity. Journal of Neuroscience. 32 (43): 15027-15035. View PDF file

Wang H*, Megill A*, He K, Kirkwood A, and Lee H-K. (2012) Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity. Neural Plasticity 2012: 272374. Web access

He K, Petrus E, Gammon N, and Lee H-K. (2012) Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity. Journal of Neuroscience. 32 (25): 8469-8474. View PDF file

Qian H, Lucas M, Zhang M, Nguyen M, Patriarchi T, Koval OM, Anderson ME, He K, Lee H-K, and Hell JW. (2012) The β2-adrenergic receptor supports prolonged theta train-induced LTP. Journal of Neurophysiology 107 (10): 2703-2712. View PDF file

Lee H-K. (2012) Ca2+-permeable AMPA receptors in homeostatic synaptic plasticity. Frontiers in Molecular Neuroscience 5: 17 (1-11). Web access

Hoe H-S, Lee H-K, and Pak DTS. (2012) The upside of APP at synapses. CNS Neuroscience & Therapeutics 18(1): 47-56. View PDF file

Lee H-K and Kirkwood A. (2011) AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex. Seminars in Cell and Developmental Biology 22: 514-520 View PDF file

He K, Goel A, Ciarkowski CE, Song L, and Lee H-K. (2011) Brain area specific regulation of synaptic AMPA receptors by phosphorylation. Communicative & Integrative Biology 4:5, 569-572. View PDF file

Petrus E*, Anguh TT*, Pho H, Lee A, Gammon N, and Lee H-K. (2011) Developmental switch in the polarity of experience-dependent synaptic changes in layer 6 of mouse visual cortex. Journal of Neurophysiology 106: 2499-2505. View PDF file

Postma F, Liu C-H, Dietsche C, Khan M, Lee H-K, Paul DL, and Kanold PO. (2011) Electrical synapses formed by Connexin36 regulate inhibition and experience-dependent plasticity. Proceedings of the National Academy of Sciences USA 108: 13770-13775. View PDF File

He K, Lee A, Song L, Kanold P, and Lee H-K. (2011) AMPA receptor subunit GluR1 (GluA1) serine-845 site is involved in synaptic depression but not in spine shrinkage associated with chemical long-term depression. Journal of Neurophysiology 105: 1897-1907. View PDF File

Goel A, Xu LW, Snyder KP, Song L, Goenaga-Vazquez Y, Megill A, Takamiya K, Huganir RL, and Lee H-K. (2011) Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity. PLoS One 6(3): e18264. Web Access

Wang H, Song L, Laird F, Wong PC, and Lee H-K. (2010) Mossy fiber long-term potentiation deficits in BACE1 knockouts can be rescued by activation of α7 nicotinic acetylcholine receptors. Journal of Neuroscience 30: 13808-13813. View PDF File

Gao M, Sossa K, Song L, Errington L, Cummings LW, Hwang H, Kuhl D, Worley P, and Lee H-K. (2010) A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex. Journal of Neuroscience 30: 7168-7178. View PDF File

Jiang B*, Huang S*, de Pasquale R, Millman D, Song L, Lee H-K, Tsumoto T, and Kirkwood A. (2010) The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period. Neuron 66: 248-259.

Lee H-K, Takamiya K, He K, Song L, and Huganir RL. (2010) Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. Journal of Neurophysiology 103: 476-489. View PDF File

He K, Song L, Cummings LW, Goldman J, Huganir RL, and Lee H-K. (2009) Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. Proceedings of the National Academy of Sciences USA 106(47): 20033-20038. View PDF File

Chung HJ and Lee H-K. (2009) Constructing a road map from synapses to behavior. EMBO Reports 10 (9): 958-962. View PDF File

Kreczko A, Goel A, Song L, and Lee H-K. (2009) Visual deprivation decreases somatic GAD65 puncta number on layer 2/3 pyramidal neurons in mouse visual cortex. Neural Plasticity 2009: 415135. Web Access

Wang H, Song L, Laird FM, Wong PC, and Lee H-K. (2008) BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. Journal of Neuroscience 28: 8677-8681View PDF File

Crombag HS, Sutton JM, Takamiya K, Lee H-K, Holland PC, Gallagher M, and Huganir RL. (2008) A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning. Behavioural Brain Research 191: 178-183. View PDF File

Lee H-K and Huganir RL. (2008) AMPA receptor regulation and the reversal of synaptic plasticity – LTP, LTD, depotentiation, and dedepression. In: Comprehensive Handbook of Learning and Memory (Chief Editor: J. Byrne, Volume Editor: J. D. Sweatt), Elsevier press.

Seol GH*, Ziburkus J*, Song L, Kim IT, Takamiya K, Huganir RL, Lee H-K, and Kirkwood A. (2007) Neuromodulators control the polarity of bidirectional associative plasticity. Neuron 55: 919-929. View PDF File

Lee H-K, Takamiya K, Kameyama K, He K, Yu S, Rossetti L, Wilen D, and Huganir RL. (2007) Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Molecular and Cellular Neuroscience 36: 86-94. View PDF File

Goel A and Lee H-K. (2007) Persistence of experience-induced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex. Journal of Neuroscience 27 (25): 6692-6700. View PDF File

Laird FM, Farah MH, Lee H-K, Savonenko AV, Price DL, and Wong PC. (2007) Beta-secretase: Physiological Role and Target Validation. In: Alzheimer’s Disease (Editors: S. S. Sisodia and R. E. Tanzi). Springer.

Goel A*, Jiang B*, Xu LW, Song L, Kirkwood A, and Lee H-K. (2006) Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience. Nature Neuroscience 9 (8): 1001-1003.  View PDF File and supplementary materials

Lee H-K. (2006) Synaptic plasticity and phosphorylation. Pharmacology & Therapeutics 112: 810-832. View PDF File

Lee H-K. (2006) AMPA receptor phosphorylation in synaptic plasticity: Insights from knockin mice. In: The Dynamic Synapse: Molecular methods in ionotropic receptor biology (Editors: J. Kittler and S. J. Moss). CRC press.

Laird FM*, Cai H*, Savonenko AV*, Farah MH*, He K, Melnidova T, Wen H, Chiang H-C, Xu G, Koliatsos V, Borchelt DR, Price DL, Lee H-K, and Wong PC. (2005) BACE1, a major determinant of selective vulnerability of the brain to Ab amyloidogenesis, is essential for cognitive, emotional and synaptic functions. Journal of Neuroscience 25 (50): 11693-11709. View PDF File

Lee H-K*, Min SS*, Gallagher M, and Kirkwood A. (2005) NMDA receptor-independent long-term depression correlates with successful aging in rats. Nature Neuroscience 8 (12): 1657-1659.

Hayashi ML, Choi S-Y, Rao BSS, Jung H-Y, Lee H-K, Zhang D, Chattarji S, Kirkwood A, and Tonegawa S. (2004) Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice. Neuron 42: 757-771. View PDF File

Lee H-K*, Takamiya K*, Han J-S, Man H, Kim C-H, Rumbaugh G, Yu S, He C, Ding L, Petralia RS, Wenthold RJ, Gallagher M, and Huganir RL. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112: 631-643. View PDF File

Kim JH, Lee H-K, Takamiya K, and Huganir RL. (2003) The role of Synaptic GTPase-Activating Protein in neuronal development and synaptic plasticity. Journal of Neuroscience 23: 1119-1124. View PDF File

Chao SZ, Lu W, Lee H-K, Huganir RL, and Wolf ME. (2002) D1 dopamine receptor stimulation increases GluR1 phosphorylation in postnatal nucleus accumbens cultures. Journal of Neurochemistry 81: 984-992. View PDF File

Choi S-Y, Morales B, Lee H-K, and Kirkwood A. (2002) Long-term depression is reduced in the visual cortex of GAD65 knockout mice.Journal of Neuroscience 22: 5271-5276. View PDF File

Kim C-H, Chung HJ, Lee H-K, Xia J, and Huganir RL. (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proceedings of the National Academy of Sciences USA 98: 11725-11730. View PDF File

Lee H-K, Barbarosie M, Kameyama K, Bear MF, and Huganir RL. (2000) Regulation of distinct AMPA receptor phosphorylation sites during bi-directional synaptic plasticity. Nature 405: 955-959. View PDF File

Banke TG, Bowie D, Lee H-K, Huganir RL, Schousboe A, and Traynelis SF. (2000) Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase and calcineurin. Journal of Neuroscience 20: 89-102. View PDF File

Lee H-K and Huganir RL. (1999) Phosphorylation of glutamate receptors. In: Handbook of Experimental Pharmacology: Ionotropic Glutamate Receptors in the CNS (Editors: P. Jonas and H. Monyer). Springer-Verlag, Heidelberg.

Lee H-K*, Kameyama K*, Huganir RL, and Bear MF. (1998) NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21: 1151-1162. View PDF File

Kameyama K*, Lee H-K*, Bear MF, and Huganir RL. (1998) Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression. Neuron 21: 1163-1175. View PDF File

Kirkwood A, Lee H-K, and Bear MF. (1995) Co-regulation of long-term potentiation and experience-dependent plasticity in visual cortex by age and experience. Nature 375:328-331. View PDF File

Selig DK, Lee H-K, Bear MF, and Malenka RC. (1995) Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation.Journal of Neurophysiology 74 (3): 1075-1082. View PDF File