2016-2020

  1. Mechanistic Studies on RNA Strand Scission From a C2′-Radical. Paul, R.; Greenberg, M. M. J. Org. Chem. 2016, 81, 9199-9205.
  2. Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase. Pidugu, L. S.; Flowers, J.; Coey, C. T.; Pozharski, E.; Greenberg, M. M.; Drohat, A. C. Biochemistry 2016, 53, 6205-6208.
  3. Probing Enhanced Double Strand Break Formation at Abasic Sites Within Clustered Lesions in Nucleosome Core Particles. Banerjee, S.; Chakraborty, S.; Jacinto, M. P.; Paul, M. D.; Balster, M. V.; Greenberg, M. M. Biochemistry 2017, 54, 14-21. (PMC: 5372979)
  4. Identification of Proximal Sites for Partially Unwound DNA Substrate in Escherichia coli Topoisomerase I With Oxidative Crosslinking. Cheng, B.; Zhou, Q.; Weng, L.; Leszyk, J. D.; Greenberg, M. M.; Tse-Dinh, Y. FEBS Lett. 2017, 591, 28-38. (PMC: 5235945)
  5. Aminyl Radical Generation via Tandem Norrish Type I Photocleavage, -Fragmentation: Independent Generation and Reactivity of the 2′-Deoxyadenosin-N6-yl Radical. Zheng, L.; Griesser, M.; Pratt, D. A.; Greenberg, M. M. J. Org. Chem. 2017, 82, 3571-3580. (PMC: 5494259)
  6. Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones. Zhang, Y.; Zhou, X.; Xie, Y.; Greenberg, M. M.; Xi, Z.; Zhou, C. J. Am. Chem. Soc. 2017, 139, 6146-6151. (PMC: 5491101)
  7. EC-Tagging Allows Cell Type-Specific RNA Analysis. Hida, N.; Aboukilila, M. Y.; Burow, D. A.; Paul, R.; Greenberg, M. M.; Fazio, M.; Beasley, S.; Spitale, R. C.; Cleary, M. D. Nucleic Acids Res. 2017, 45, e138.
  8. The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase Theta. Laverty, D. J.; Averill, A. M.; Doublié, S.; Greenberg, M. M. ACS Chem. Biol. 2017, 12, 1584-1592. (PMC: 5499511)
  9. Synergistic Effects of an Irreversible DNA Polymerase Inhibitor and DNA Damaging Agents on HeLa Cells. Paul, R.; Banerjee, S.; Greenberg, M. M. ACS Chem. Biol. 2017, 12, 1576-1583. (PMC: 5492961) (Highlighted (“Spotlight”) in Chem. Res. Toxicol. 2017, 30, 1367-1368.)
  10. 5-Formylcytosine Yields DNA-Protein Crosslinks in Nucleosome Core Particles. Li, F.; Zhang, Y.; Bai, J.; Greenberg, M. M.; Xi, Z.; Zhou, C. J. Am. Chem. Soc. 2017, 139, 10617-10620.
  11. Independent Generation and Reactivity of Thymidine Radical Cations. Sun, H.; Taverna Porro, M. L.; Greenberg, M. M. J. Org. Chem. 2017, 82, 11072-11083.
  12. DNA Damage Emanating From a Neutral Purine Radical Reveals the Sequence Dependent Convergence of the Direct and Indirect Effects of -Radiolysis. Zheng, L.; Greenberg, M. M. J. Am. Chem. Soc. 2017, 139, 17751-17754.
  13. Independent Photochemical Generation and Reactivity of Nitrogen-Centered Purine Nucleoside Radicals From Hydrazines. Zheng, L.; Lin, L.; Qu, K.; Adhikary, A.; Sevilla, M. D.; Greenberg, M. M. Org. Lett. 2017, 19, 6444-64447.
  14. In Vitro Pol Theta Bypass of Thymidine Glycol Forms Sequence-Dependent Frameshift Mutations. Laverty, D. J.; Greenberg, M. M. Biochemistry 2017, 56, 6726-6733.
  15. An Oxidized Abasic Lesion Inhibits Base Excision Repair Leading to DNA Strand Breaks in a Trinucleotide Repeat Tract. Beaver, J. M.; Lai, Y.; Rolle, S. J.; Weng, L.; Greenberg, M. M.; Liu, Y. PLoS ONE 13(2): e0192148. https://doi.org/10.1371/journal.pone.0192148 (PMC: 5794147)
  16. Traceless Tandem Lesion Formation in DNA From a Nitrogen-Centered Purine Radical. Zheng, L.; Greenberg, M. M. J. Am. Chem. Soc. 2018, 140, 6400-6407. (PMC: 5966344)
  17. Mechanistic Insight Through Irreversible Inhibition: DNA Polymerase  Uses a Common Active Site for Polymerase and Lyase Activities. Laverty, D. J.; Mortimer, I. P.; Greenberg, M. M. J. Am. Chem. Soc. 2018, 140, 9034-9037.
  18. Rotational Effects Within Nucleosome Core Particles on Abasic Site Reactivity. Wang, R.; Yang, K.; Banerjee, S.; Greenberg, M. M. Biochemistry 2018, 57, 3945-3952.
  19. Independent Generation of Reactive Intermediates Leads to an Alternative Mechanism for Strand Damage Induced by Hole Transfer in Poly•(dA-T) Sequences. Sun, H.; Zheng, L.; Greenberg, M. M. J. Am. Chem. Soc. 2018, 140, 11308-11316.
  20. Enhanced Cleavage at Abasic Sites Within Clustered Lesions in Nucleosome Core Particles. Yang, K.; Greenberg, M. M. ChemBioChem 2018, 19, 2061-2065. Designated as a Very Important Paper (VIP) by the Editor.
  21. Facile Synthesis of 5-Methylene-2-pyrrolones. Jacinto, M. P.; Pichling, P.; Greenberg, M. M. Org. Lett. 2018, 20, 4885-4887.
  22. Expanded Substrate Scope of DNA Polymerase Theta and DNA Polymerase Beta: Lyase Activity on 5′-Overhangs and Clustered Lesions. Laverty, D. J.; Greenberg, M. M. Biochemistry 2018, 57, 6119-6127. (PMC: 6200648)
  23. Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Leads to Substantial DNA-Histone Cross-links Within Nucleosome Core Particles. Bai, J.; Zhang, Y.; Xi, Z.; Greenberg, M. M.; Zhou, C. Chem. Res. Toxicol. 2018, 31, 1364-1372.
  24. Histone Tails Decrease N7-Methyl-2′-Deoxyguanosine Depurination and Yield DNA-Protein Crosslinks in Nucleosome Core Particles and Cells. Yang, K.; Park, D.; Tretyakova, N. Y.; Greenberg, M. M. Proc. Natl. Acad. Sci. USA 2018, 115, E11212-E11220. Highlighted in Chemical & Engineering News (https://cen.acs.org/biological-chemistry/nucleic-acids/Chemicals-cause-unexpected-DNA-damage/96/i48) and by the NIEHS.
  25. Histone Tail Sequences Balance Their Role in Genetic Regulation and the Need to Protect DNA Against Destruction in Nucleosome Core Particles Containing Abasic Sites. Yang, K.; Greenberg, M. M. ChemBioChem 2019, 20, 78-82.
  26. A Guardian Residue Hinders Insertion of a Fapy•dGTP Analog by Modulating the Open-Closed DNA Polymerase Transition. Smith, M. R.; Shock, D. D.; Beard, W. A.; Greenberg, M. M.; Freudenthal, B. D.; Wilson, S. H. Nucleic Acids Res. 2019, 47, 3197-3207.
  27. Reactivity of the Major C5′-Oxidative DNA Damage Product in Nucleosome Core Particles. Rana, A.; Yang, K.; Greenberg, M. M. ChemBioChem 2019, 20, 672-676. Designated as a Very Important Paper (VIP) by the Editor.
  28. Effect of Histone Lysine Methylation on DNA Lesion Reactivity in Nucleosome Core Particles.Yang, K.; Prasse, C.; Greenberg, M. M. Chem. Res. Toxicol. 2019, 32, 910-916. Invited article for special issue: Epigenetics in Toxicology.
  29. Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles. Sun, H.; Zheng, L.; Yang, K.; Greenberg, M. M. J. Am. Chem. Soc. 2019, 141, 10154-10158.
  30. Reactivity of 3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles.Yang, K.; Sun, H.; Lowder, L.; Varadarajan, S.; Greenberg, M. M. Chem. Res. Toxicol. 2019, 32, 2118-2124. Selected to be Editor’s Choice by the American Chemical Society; September 30, 2019.
  31. DNA-Protein Cross-link Formation in Nucleosome Core Particles Treated with Methyl Methanesulfonate. Yang, K.; Greenberg, M. M. Chem. Res. Toxicol. 2019, 32, 2144-2151.
  32. Mutagenic Effects of a 2-Deoxyribonolactone – Thymine Glycol Tandem Lesion in Human Cells. Naldiga, S.; Huang, H.; Greenberg, M. M.; Basu, A. K. Biochemistry 2020, 59, 417-424.
  33. Solid-Phase Synthesis of Oligonucleotides Containing the N6-(2-Deoxy-a,b-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy•dG) Oxidative Damage Product Derived from 2′-Deoxyguanosine. Yang, H.; Tang, J. A.; Greenberg, M. M. Chem. – Eur. J. 2020, 26, 5441 – 5448. Designated by the editor as a Hot Paper.
  34. Light-Controlled Twister Ribozyme With Single Molecule Detection Resolves RNA Function in Time and Space. Korman, A.; Sun, H.; Hua, B.; Yang, H.; Capilato, J. N.; Paul, R.; Panja, S.; Ha, T.; Greenberg, M. M.; Woodson, S. A. Proc. Natl. Acad. Sci. USA 2020, 117, 12080-12086.
  35. Independent Generation and Time-Resolved Detection of 2′-Deoxyguanosin-N2-yl Radicals. Zheng, L.; Dai, X.; Su, H.; Greenberg, M. M. Angew. Chem. Int. Ed. 2020, 59, 13406-13413. Designated by the editor as a Hot Paper.
  36. Independent Generation and Reactivity of 2’-Deoxyguanosin-N1-yl Radical. Zheng, L.; Greenberg, M. M. J. Org. Chem. 2020, 85, 8665-8672.
  37. Effects of Histone Proteins and Local Polarity on Alkylated DNA Reactivity in Nucleosome Core Particles. Yang, K.; Han, J. H.; Greenberg, M. M. (submitted).