Welcome to the Greenberg group, where synthetic and mechanistic organic chemistry, biochemistry, as well as molecular and cell biology are used to study nucleic acids.

Research projects in our group include: nucleic acid chemistry in nucleosomes, DNA and RNA damage, DNA repair, photochemical control of nucleic acids, sensors for DNA lesions, DNA repair inhibitors and radiosensitizing agents.

Images of DNA and RNA representing research in the Greenberg Group

We are accepting graduate students and postdoctoral associates. Postdoctoral applicants should submit an introductory letter, CV, research summary, and pdfs of manuscripts submitted and/or accepted for publication to Professor Greenberg at mgreenberg -at-jhu-dot-edu.

Contact Us

Professor Marc M. Greenberg

mgreenberg-at-jhu.edu
Phone: 410-516-8095
Fax: 410-516-8420

The Johns Hopkins University
Department of Chemistry
3400 N. Charles St.
Baltimore, MD 21218

News & Announcements

  • October 2021: Congratulations to our colleague, Professor Xiongyi Huang on his designation as a prestigious Packard Fellow for Science and Engineering. Check it out: https://www.packard.org/insights/news/meet-the-2021-class-of-packard-fellows-for-science-and-engineering/
  • September 2021: Congratulations to Haihui on his publication in JACS on the reactivity of 2′-deoxycytidin-N4-yl radical (dC•) in DNA. dC• forms tandem lesions and participates in electron transfer in DNA.
  • September 2021: Congratulations to Haozhe on his collaborative publication in DNA Repair on the mutagenicity of the structurally unusual and biologically important DNA lesion, Fapy•dG, in mammalian cells.
  • August 2021: Welcome to our new postdoctoral scholar, Hasan Howlader.
  • July 2021: Congratulations to Shelby on her publication in ACS Chemical Biology. Shelby determined the DNA polymerase beta inhibition is synthetically lethal in BRCA1-deficient cells. Shelby’s results increase the importance of the enzyme as an anti-cancer target.
  • July 2021: Congratulations to Shelby on her publication in ChemBioChem concerning the identification of domain specific inhibitors of DNA polymerase beta. The editors gave it VIP designation.
  • May 2021: Best of luck to Shelby in her position at Glen Research.
  • May 2021: Congratulations to Shelby on her publication in the Journal of the American Chemical Society concerning the identification of a covalent inhibitor of DNA polymerase beta that is potent and selective in cells.
  • February 2021: Congratulations to Morgan on his publication in the Journal of the American Chemical Society concerning the development and application of a probe for identifying poly(ADP-ribose) – protein interactions.
  • January 2021: Welcome to our new postdoctoral scholar, Dr. Lu Cheng
  • December 2020: Congratulations to Dr. Shelby Yuhas on successfully defending her PhD dissertation!
  • September 2020: Welcome to our new CBI rotation student, Haley Moran.
  • June 2020: Welcome to our new graduate student, Amanda Nguyen from the CDMBB program.