Welcome to the Greenberg group, where synthetic and mechanistic organic chemistry, biochemistry, as well as molecular and cell biology are used to study nucleic acids.

Research projects in our group include: nucleic acid chemistry in nucleosomes, DNA and RNA damage, DNA repair, photochemical control of nucleic acids, sensors for DNA lesions, DNA repair inhibitors and radiosensitizing agents.

Images of DNA and RNA representing research in the Greenberg Group

We are accepting graduate students and postdoctoral associates. Postdoctoral applicants should submit an introductory letter, CV, research summary, and pdfs of manuscripts submitted and/or accepted for publication to Professor Greenberg at mgreenberg -at-jhu-dot-edu.

Contact Us

Professor Marc M. Greenberg

mgreenberg-at-jhu.edu
Phone: 410-516-8095
Fax: 410-516-8420

The Johns Hopkins University
Department of Chemistry
3400 N. Charles St.
Baltimore, MD 21218

News & Announcements

  • July 2021: Congratulations to Shelby on her publication in ACS Chemical Biology. Shelby determined the DNA polymerase beta inhibition is synthetically lethal in BRCA1-deficient cells. Shelby’s results increase the importance of the enzyme as an anti-cancer target.
  • July 2021: Congratulations to Shelby on her publication in ChemBioChem concerning the identification of domain specific inhibitors of DNA polymerase beta. The editors gave it VIP designation.
  • May 2021: Best of luck to Shelby in her position at Glen Research.
  • May 2021: Congratulations to Shelby on her publication in the Journal of the American Chemical Society concerning the identification of a covalent inhibitor of DNA polymerase beta that is potent and selective in cells.
  • February 2021: Congratulations to Morgan on his publication in the Journal of the American Chemical Society concerning the development and application of a probe for identifying poly(ADP-ribose) – protein interactions.
  • January 2021: Welcome to our new postdoctoral scholar, Dr. Lu Cheng
  • December 2020: Congratulations to Dr. Shelby Yuhas on successfully defending her PhD dissertation!
  • September 2020: Welcome to our new CBI rotation student, Haley Moran.
  • June 2020: Welcome to our new graduate student, Amanda Nguyen from the CDMBB program.
  • June 2020: Congratulations to Liwei on his publication in the Journal of Organic Chemistry on the generation and reactivity of the thermodynamically favored guanine radical involved in DNA damage.
  • May 2020: Congratulations to Liwei on his joint publication with the Su group in Angewandte Chemie on the generation and reactivity of a major purine radical involved in DNA damage. The editors selected it as a “Hot Paper.”
  • May 2020: Congratulations to Huabing and Haozhe on their joint publication with the Woodson and Ha groups in PNAS on photo triggered ribozyme folding using single molecule detection.