Welcome to the Greenberg group, where synthetic and mechanistic organic chemistry, biochemistry, as well as molecular and cell biology are used to study nucleic acids.

Greenberg Group – July 2022

Research projects in our group include: nucleic acid chemistry in nucleosomes, DNA and RNA damage, DNA repair, photochemical control of nucleic acids, sensors for DNA lesions, DNA repair inhibitors and radiosensitizing agents.

Images of DNA and RNA representing research in the Greenberg Group

We are accepting graduate students and postdoctoral associates. Postdoctoral applicants should submit an introductory letter, CV, research summary, and pdfs of manuscripts submitted and/or accepted for publication to Professor Greenberg at mgreenberg -at-jhu-dot-edu.

Contact Us

Professor Marc M. Greenberg

mgreenberg-at-jhu.edu
Phone: 410-516-8095
Fax: 410-516-8420

The Johns Hopkins University
Department of Chemistry
3400 N. Charles St.
Baltimore, MD 21218

News & Announcements

  • June 2022: Welcome to Christopher McDonald, an incoming CBI student who will rotate with us this summer.
  • May 2022: Welcome to Tori Tavernier, who is conducting research with us as an NSF REU student.
  • May 2022: Welcome to Dhananjani Adikari Eriyagama, our newest postdoctoral scholar.
  • May 2022: Congratulations to Tingyu Wen on receiving the Ada Sinz Hill fellowship for advanced graduate students.
  • May 2022: Congratulations to Haozhe Yang on his publication in JACS. This was joint effort with the Freudenthal and Basu labs on providing a structural basis for understanding the mutagenic effects of the DNA lesion, formamidopyrimidine (Fapy•dG).
  • April 2022: Congratulations to Marco Jacinto on his publication in JACS. Marco demonstrated that a DNA damage-induced histone modification is produced in cells.
  • April 2022: Our review on the Reactivity of Damaged DNA in Nucleosome Core Particles is published in Accounts of Chemical Research.
  • January 2022: Congratulations to Marco Jacinto on defending his Ph.D. Best of luck at Amgen!
  • December 2021: Welcome to our new graduate student, Son Vu.
  • October 2021: Congratulations to our colleague, Professor Xiongyi Huang on his designation as a prestigious Packard Fellow for Science and Engineering. Check it out: https://www.packard.org/insights/news/meet-the-2021-class-of-packard-fellows-for-science-and-engineering/
  • September 2021: Congratulations to Haihui on his publication in JACS on the reactivity of 2′-deoxycytidin-N4-yl radical (dC•) in DNA. dC• forms tandem lesions and participates in electron transfer in DNA.
  • September 2021: Congratulations to Haozhe on his collaborative publication in DNA Repair on the mutagenicity of the structurally unusual and biologically important DNA lesion, Fapy•dG, in mammalian cells.
  • August 2021: Welcome to our new postdoctoral scholar, Hasan Howlader.
  • July 2021: Congratulations to Shelby on her publication in ACS Chemical Biology. Shelby determined the DNA polymerase beta inhibition is synthetically lethal in BRCA1-deficient cells. Shelby’s results increase the importance of the enzyme as an anti-cancer target.
  • July 2021: Congratulations to Shelby on her publication in ChemBioChem concerning the identification of domain specific inhibitors of DNA polymerase beta. The editors gave it VIP designation.