The Greenberg Group > 2011-2015

2011-2015

  1. Long Patch Base Excision Repair Compensates for DNA Polymerase  Inactivation by the C4′-Oxidized Abasic Site. Jacobs, A. C.; Kreller, C. R.; Greenberg, M. M. Biochemistry 2011, 50, 136-143.
  2. An Oxidized Abasic Lesion as an Intramolecular Source of DNA Adducts. Guan, L.; Greenberg, M. M. Aust. J. Chem. 2011, 64, 438-442. Invited article for Athelstan L. J. Beckwith memorial issue.
  3. Product and Mechanistic Analysis of the Reactivity of a C6-Pyrimidine Radical in RNA. Jacobs, A. C.; Resendiz, M. J. E.; Greenberg, M. M. J. Am. Chem. Soc. 2011, 133, 5152-5159.
  4. Repair of the Major Lesion Resulting from C5′-Oxidation of DNA. Jung, K. Y.; Kodama, T.; Greenberg, M. M. Biochemistry 2011, 50, 6273-6279.
  5. Intracellular Detection of Cytosine Incorporation in Genomic DNA Using 5-Ethynyl-2′-Deoxycytidine. Guan, L.; van der Heijden, G.; Bortvin, A.; Greenberg, M. M. ChemBioChem 2011, 12, 2184-2190. Selected by the editor as a Very Important Paper.
  6. Probing DNA Interstrand Cross-link Formation by an Oxidized Abasic Site Using Nonnative Nucleotides. Sczepanski, J. T.; Hiemstra, C. N.; Greenberg, M. M. Bioorganic & Med. Chem. 2011, 19, 5788-5793.
  7. Direct Strand Scission in Double Stranded RNA via a C5-Pyrimidine Radical. Resendiz, M. J. E.; Pottiboyina, V.; Sevilla, M. D.; Greenberg, M. M. J. Am. Chem. Soc. 2012, 134, 3917-3924.
  8. Histone Catalyzed Cleavage of Nucleosomal DNA Containing 2-Deoxyribonolactone. Zhou, C.; Greenberg, M. M. J. Am. Chem. Soc. 2012, 134, 8090-8093. “Spotlighted” in the J. Am. Chem. Soc. 2012, 134, 9031.
  9. DNA Damage by C1027 Involves Hydrogen Atom Abstraction and Addition to Nucleobases. San Pedro, J. M. N.; Beerman, T. A.; Greenberg, M. M. Bioorganic & Med. Chem. 2012, 20, 4744-4750.
  10. Quantification of 8-OxodGuo Lesions in Double-Stranded DNA Using a Photoelectrochemical DNA Sensor. Zhang, B.; Guo, L.-H.; Greenberg, M. M. Anal. Chem. 2012, 84, 6048-6053.
  11. Photochemical Generation of the Major Hydroxyl Radical Adduct of Thymidine. San Pedro, J. M. N.; Greenberg, M. M. Org. Lett. 2012, 14, 2866-2869.
  12. Photochemical Control of RNA Structure by Disrupting -Stacking. Resendiz, M. J. E.; Schön, A; Freire, E.; Greenberg, M. M. J. Am. Chem. Soc. 2012, 134, 12478-12481.
  13. Mechanistic Studies on Histone Catalyzed Cleavage of Apyrimidinic/Apurinic Sites in Nucleosome Core Particles. Zhou, C.; Sczepanski, J. T.; Greenberg, M. M. J. Am. Chem. Soc. 2012, 134, 16734-16741.
  14. Human DNA Polymerase , But Not , Can Bypass a 2-Deoxyribonolactone Lesion Together With Proliferating Cell Nuclear Antigen. Crespan, E.; Pasi, E.; Imoto, S.; Greenberg, M. M.; Hübscher, U.; Maga, G. ACS Chem. Biol. 2013, 8, 336-344.
  15. Transforming Thymidine Into a Magnetic Resonance Imaging Probe for Monitoring Gene Expression. Bar-Shir, A.; Liu, G.; Liang, Y.; Yadav, N. N.; McMahon, M. T.; Walczak, P.; Nimmagadda, S.; Pomper, M. G.; Tallman, K. A.; Greenberg, M. M.; van Zijl, P. C. M.; Bulte, J. W. M.; Gilad, A. A. J. Am. Chem. Soc. 2013, 135, 1617-1624.
  16. DNA Polymerase  Inactivation by Oxidized Abasic Sites. Stevens, A. J.; Guan, L.; Bebenek, K.; Kunkel, T. A.; Greenberg, M. M. Biochemistry 2013, 52, 975-983.
  17. Nucleosome Core Particle Catalyzed Strand Scission at Abasic Sites. Sczepanski, J. T.; Zhou, C.; Greenberg, M. M. Biochemistry 2013, 52, 2157-2164.
  18. Histone Modification via Rapid Cleavage of C4′-Oxidized Abasic Sites in Nucleosome Core Particles. Zhou, C.; Sczepanski, J. T.; Greenberg, M. M. J. Am. Chem. Soc. 2013, 135, 5274-5277. “Spotlighted” in the J. Am. Chem. Soc. 2013, 135, 5933.
  19. Deconvoluting the Reactivity of Two Intermediates Formed From Modified Pyrimidines. Weng, L.; Horvat, S. M.; Schiesser, C. S.; Greenberg, M. M. Org. Lett. 2013, 15, 3618-3621.
  20. Photochemical Control of DNA Structure via Radical Disproportionation. San Pedro, J. M. N.; Greenberg, M. M. ChemBioChem 2013, 14, 1590-1596. Cited by Faculty1000: http://f1000.com/prime/718072208?bd=1&ui=21843.
  21. Synthesis of a Reporter Probe for Monitoring HSV1-Tk Reporter Gene Expression Using Chemical Exchange Saturation Transfer (CEST) MRI. Bar-Shir, A.; Liu, G.; Greenberg, M. M.; Bulte, J. W. M.; Gilad, A. A. Nature Protocols 2013, 8, 2380-2391.
  22. DNA Polymerase V Kinetics Support the Instructive Nature of an Oxidized Abasic Lesion in E. coli. Bajacan, J. V. E.; Greenberg, M. M. Biochemistry 2013, 52, 6301-6303.
  23. DNA Double Strand Cleavage via Interstrand Hydrogen Atom Transfer. Taverna Porro, M. L.; Greenberg, M. M. J. Am. Chem. Soc. 2013, 135, 16368-16371. “Spotlighted” in the J. Am. Chem. Soc. 2013, 135, 16745. Cited by Faculty1000: http://f1000.com/prime/718152314?bd=1&ui=21843.
  24. Reduced Repair Capacity of a DNA Clustered Damage Site Comprised of 8-Oxo-7,8-dihydroguanine and 2-Deoxyribonolactone Results in an Increased Mutagenic Potential of These Lesions. Cunniffe, S.; Smirnova, E.; O’Neill, P.; Greenberg, M. M.; Lomax, M. E. Mutat. Res.: Fundam. Mol. Mech. Mutagen. 2014, 762, 32-39.
  25. Irreversible Inhibition of DNA Polymerase  by Small Molecule Mimics of a DNA Lesion. Arian, D.; Hedayati, M.; Zhou, H.; Bilis, Z.; Chen, K.; DeWeese, T. L.; Greenberg, M. M. J. Am. Chem. Soc. 2014, 136, 3176-3183.
  26. 5.6-Dihydropyrimidine Peroxyl Radical Reactivity in DNA. San Pedro, J. M. N.; Greenberg, M. M. J. Am. Chem. Soc. 2014, 136, 3928-3936.
  27. DNA Interstrand Cross-Linking Upon Irradiation of Aryl Halide C-Nucleotides. Hou, D.; Greenberg, M. M. J. Org. Chem. 2014, 79, 1877-1884.
    Designated by the Journal as a Feature Article. Selected by the American Chemical Society as an ACS Editors’ Choice paper. “ACS Editors’ Choice is a new initiative wherein, based on recommendations from Editors, one article from across the portfolio is selected each day of the year and upon publication is made immediately available as open access sponsored by ACS Publications.”
  28. DNA Damage by Histone Radicals in Nucleosome Core Particles. Zhou, C.; Greenberg, M. M. J. Am. Chem. Soc. 2014, 136, 6562-6565.
  29. Quantitative Detection of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Using Chemical Tagging and qPCR. Bajacan, J. V. E.; Hong, I. S.; Penning, T. M.; Greenberg, M. M. Chem. Res. Toxicol. 2014, 27, 1227-1235.
  30. Synthesis of Cross-linked DNA Containing Oxidized Abasic Site Analogues. Ghosh, S.; Greenberg, M. M. J. Org. Chem. 2014, 79, 5948-5957. Designated by the Journal as a Feature Article.
  31. Nucleotide Excision Repair of Chemically Stabilized Analogues of DNA Interstrand Cross-links Produced From Oxidized Abasic Sites. Ghosh, S.; Greenberg, M. M. Biochemistry 2014, 53, 5958-5965.
  32. Interstrand Cross-Link and Bioconjugate Formation in RNA From a Modified Nucleotide. Sloane, J. L.; Greenberg, M. M. J. Org. Chem. 2014, 79, 9792-9798.
  33. Independent Generation and Reactivity of the Uridin-2′-yl Radical. Paul, R.; Greenberg, M. M. J. Org. Chem. 2014, 79, 10303-10310.
  34. Rapid RNA Strand Scission Following C2′-Hydrogen Atom Abstraction. Paul, R.; Greenberg, M. M. J. Am. Chem. Soc. 2015, 137, 596-599.
  35. Probing Interactions Between Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis. Weng, L.; Zhou, C.; Greenberg, M. M. ACS Chem. Biol. 2015, 10, 622-630. “Spotlighted” in Chem. Res. Toxicol. 2015, 28, 3.
  36. Double Strand Breaks From a Radical Commonly Produced by DNA Damaging Agents. Taverna Porro, M. L.; Greenberg, M. M. Chem. Res. Toxicol. 2015, 28, 810-816.
    Selected by the American Chemical Society as an ACS Editors’ Choice paper. “ACS Editors’ Choice is an initiative wherein, based on recommendations from Editors, one article from across the portfolio is selected each day of the year and upon publication is made immediately available as open access sponsored by ACS Publications.” The manuscript was also highlighted on the journal cover.
  37. Unlike Catalyzing Error-Free Bypass of 8-OxodGuo, DNA Polymerase λ Is Responsible for a Significant Part of Fapy•dG-Induced G→T Mutations in Human Cells. Pande, P.; Haraguchi, K.; Jiang, Y.-L.; Greenberg, M. M.; Basu, A. K. Biochemistry 2015, 54, 1859-1862.
  38. Light-Triggered RNA Annealing by an RNA Chaperone. Panja, S.; Paul, R.; Greenberg, M. M.; Woodson, S. A. Angew. Chem. Int. Ed. 2015, 54, 7281-7284.
  39. Sequence Selective Tagging of 8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) Using PNAs. Hong, I. S.; Greenberg Bioorg. & Med. Chem. Lett. 2015, 25, 4918-4921. Invited submission for a special Symposium-in-Print issue entitled “Recent Advances in Medicinal Chemistry and Chemical Biology” to commemorate 25 years since Bioorg. & Med. Chem. Lett. began publishing.
  40. Rapid Histone Catalyzed DNA Lesion Excision and Accompanying Protein Modification in Nucleosomes and Nucleosome Core Particles. Weng, L.; Greenberg, M. M. J. Am. Chem. Soc. 2015, 137, 11022-11031.
  41. Correlation of Thermal Stability and Structural Distortion of DNA Interstrand Cross-links Produced From Oxidized Abasic Sites Explain Their Selective Formation and Repair. Ghosh, S.; Greenberg, M. M. Biochemistry 2015, 54, 6274-6283.
  42. Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents that are Incorporated in DNA by Polymerases. Rudra, A.; Hou, D.; Zhang, Y.; Coulter, J.; Zhao, H.; DeWeese, T. L.; Greenberg, M. M. J. Org. Chem. 2015, 80, 10675-10685.
  43. Mutagenic Bypass of an Oxidized Abasic Lesion-Induced DNA Interstrand Cross-link Analogue by Human Translesion Synthesis DNA Polymerases. Xu, W.; Ouellette, A.; Ghosh, S.; O’Neill, T. C.; Greenberg, M. M.; Zhao, L. Biochemistry 2015, 54, 7409-7422.