Publications

123. Mark A. Hutchinson, Blessing D. Deeyaa, Shane R. Byrne, Sierra J. Williams & Steven E. Rokita “Directing Quinone Methide-Dependent Alkylation and Cross-Linking of Nucleic Acids With Quaternary Amines” Bioconjugate Chem. 2020, 31, 1486-1496 (10.1021/acs.bioconjchem.0c00166).

122. Blessing D. Deeyaa and Steven E. Rokita “Migratory Ability of Quinone Methide-Generating Acridine Conjugates in DNA” Org. Biomol. Chem. 2020, 18, 1671 – 1678.

121. Steven E. Rokita “Reductive Dehalogenases” in Comprehensive Natural Products III: Chemistry and Biology (H.-w. Liu & T. Begley, eds.) Wiley, 2020, vol. 4, ch. 8, 157-186.

120. Shane R. Byrne, Kun Yang and Steven E. Rokita “Effect of Nucleosome Assembly on Alkylation by a Dynamic Electrophile” Chem. Res. Toxicol. 2019, 32, 917-925. (10.1021/acs.chemrestox.9b00057)

119. Jimin Hu, Qi Su, Jamie Schlessman and Steven E. Rokita “Redox Control of Iodotyrosine Deiodinase” Protein Science 2019, 28, 68-78. (https://doi.org/10.1002/pro.3479)

118. Zuodong Sun and Steven E. Rokita “Towards a Halophenol Dehalogenase from Iodotyrosine Deiodinase via Computational Design” ACS Catalysis 2018, 8, 11783–11793 (DOI: 10.1021/acscatal.8b03587)

117. Abhishek Phatarphekar, Qi Su, Suk Ho Eun, Xin Chen, and Steven E. Rokita “The Importance of a Halotyrosine Dehalogenase for Drosophila Fertility” J. Biol. Chem. 2018, 293, 10314–10321. (DOI 10.1074/jbc.RA118.003364)

116. Zuodong Sun, Qi Su, Steven E Rokita* “The Distribution and Mechanism of Iodotyrosine
Deiodinase Defied Expectations” Arch. Biochem. Biophys. 2017, 632, 77-87.
(DOI: 10.1016/j.abb.2017.07.019)

115. Qi Su, Petrina A. Boucher, and Steven E. Rokita* “Conversion of a Dehalogenase to a
Nitroreductase by Swapping its Flavin Cofactor with a 5-Deazaflavin Analog.” Angew. Chem.
Int. Ed. 2017, 56, 10862-10866 (DOI: 10.1002/anie.201703628).

114. Nattha Ingavat, Jennifer M. Kavran, Zuodong Sun, and Steven E. Rokita* “Active Site Binding
is not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase” Biochemistry 2017, 56,
1130-1139. (DOI: 10.1021/acs.biochem.6b01308)

113.Abhishek Phatarphekar, and Steven E. Rokita* “Functional Analysis of Iodotyrosine Deiodinase
From Drosophila melanogaster” Protein Science 2016, 25, 2187-2195.

112.Shalini Saha* and Steven E. Rokita* “An activator of an Adenylation Domain Revealed by
Activity but not Sequence Homology” ChemBioChem 2016, 17, 1818-1823.

111. Chengyun Huang, Yang Liu and Steven E. Rokita* “Targeting Duplex DNA with the Reversible
Reactivity of Quinone Methides” Signal Transduct Target Ther. 2016, 1, 16009.
(doi:10.1038/sigtrans.2016.9, http://www.nature.com/articles/sigtrans20169)

110. Chengyun Huang and Steven E. Rokita* “Promoting the Rate of DNA Alkylation with an
Electron Rich Quinone Methide Intermediate” Front. Chem. Sci. Eng. 2016, 10, 213-221.

109. Arnab Mukherjee and Steven E. Rokita “A Single Amino Acid Switch Between a FlavinDependent
Dehalogenase and Nitroreductase” J. Am. Chem. Soc. 2015, 137, 15342–15345.
[PMCID# PMC4684082]

108. Tuomas Lönnberg,* Mark A. Hutchinson and Steven E. Rokita “Selective Alkylation of C-Rich
Bulge Motifs in Nucleic Acids by Quinone Methide Derivatives” Chem. Eur. J. 2015, 21,
13127-13186. (http://dx.doi.org/10.1002/chem.201502014)

107. Kostyantyn D. Bobyk, David P. Ballou and Steven E. Rokita* “Rapid Kinetics of Dehalogenation
Promoted by Iodotyrosine Deiodinase from Human Thyroid” Biochemistry 2015, 54, 4487–4494.
(http://dx.doi.org/10.1021/acs.biochem.5b00410). [PMCID# PMC4938124]

106. Shalini Saha*, Wei Li, Barbara Gerratana, and Steven E. Rokita* “Identification of the
Dioxygenase-Generated Intermediate Formed During Biosynthesis of the Dihydropyrrole
Moiety Common to Anthramycin and Sibiromycin” Bioorg. Med. Chem. 2015, 23, 449-454
(doi:10.1016/j.bmc.2014.12.024).

105. Jimin Hu, Watchalee Chuenchor, and Steven E. Rokita* “A Switch Between One- and TwoElectron
Chemistry of the Human Flavoprotein Iodotyrosine Deiodinase is Controlled by
Substrate” J. Biol. Chem. 2015, 290, 590-600 (doi:10.1074/jbc.M114.605964).

104. Fazel Fakhari and Steven E. Rokita* “A Walk Along DNA Using Bipedal Migration of a
Dynamic and Covalent Cross-linker” Nature Commun. 2014, 5 5591 (doi: 10.1038/ncomms6591

103. Michael P. McCrane, Mark A. Hutchinson, Omer Ad, and Steven E. Rokita* “Oxidative
Quenching of Quinone Methide Adducts Reveals Transient Products of Reversible Alkylation in
Duplex DNA” Chem. Res. Toxicol. 2014, 27, 1282–1293 (http://dx.doi.org/10.1021/tx500152d).

102. Neil P. Campbell and Steven E. Rokita* “Electron Transport in DNA Initiated by Diaminonaphthalene
Donors Alternatively Bound by Non-Covalent and Covalent Association” Org.
Biomol. Chem. 2014, 12, 1143 – 1148 (http://xlink.rsc.org/?doi=C3OB42433B).

101. Abhishek Phatarphekar, Jennifer M. Buss, and Steven E. Rokita* “Iodotyrosine Deiodinase:
A Unique Flavoprotein Present in Organisms of Diverse Phyla” Mol. BioSyst. 2014,
10, 86-92. (http://xlink.rsc.org/?doi=C3MB70398C) [Highlighted in Nat. Chem. Biol. 2014, 10, 2.]

100. Steven E. Rokita “Synthetic Thyroid Hormone” in Iodine: Chemistry and Application (T. Kaiho,
ed.) Wiley, 2014, Ch. 21. pp. 411-420.

99. Fazel Fakhari, Yun-Yun K. Chen and Steven E. Rokita* “Enhancing Excess Electron Transport
in DNA” Chem. Commun. 2013, 49, 7073-7075. (http://xlink.rsc.org/?doi=C3CC43887B)

98. Amethist S. Finch, William B. Davis and Steven E. Rokita* “Accumulation of the Cyclobutane
Thymine Dimer in Defined Sequences of Free and Nucleosomal DNA” Photochem. Photobiol.
Sci. 2013, 12, 1474–1482. (http://xlink.rsc.org/?doi=C3PP50147G)

97. Steven E. Rokita “Flavoprotein Dehalogenases” in Handbook of Flavoproteins, vol. 1 (R. Hille,
S. M. Miller, B. Palfey eds.) DeGruyter, Berlin, 2013. p. 337-350.

96. Jennifer M. Buss, Patrick M. McTamney and Steven E. Rokita* “Expression of a Soluble Form of
Iodotyrosine Deiodinase for Active Site Characterization by Engineering the Native Membrane
Protein from Mus musculus” Protein Science 2012, 21, 351-361.

95. Yang Liu and Steven E. Rokita* “Inducible Alkylation of DNA by a Quinone Methide-Peptide
Nucleic Acid Conjugate” Biochemistry 2012, 51, 1020-1027. [http://dx.doi.org/10.1021/bi201492b]

94. Michael P. McCrane, Emily E. Weinert, Ying Lin, Eugene P. Mazzola, Yiu-Fai Lam, Peter F.
Scholl, and Steven E. Rokita* “Trapping a Labile Adduct Formed between an ortho-Quinone
Methide and 2′-Deoxycytidine” Org. Lett. 2011, 13, 1186–1189. (DOI: 10.1021/ol200071p).

93. Abulfazl Fakhari M. and Steven E. Rokita* “A New Solvatochromic Fluorophore With High
Sensitivity for Studying Biopolymers” Chem. Commun. 2011, 47, 4222 – 4224. (DOI:
10.1039/c0cc04917d)

92. Seung Jae Lee, Jamie L. Michalek, Angelique N. Besold, Steven E. Rokita, Sarah L. J. Michel*
“Classical Cys2His2 Zinc Finger Peptides are Rapidly Oxidized by either H2O2 or O2 Irrespective
of Metal Coordination” Inorg. Chem. 2011, 50, 5442–5450. (DOI: 10.1021/ic102252a).

91. Clifford S. Rossiter, Emilia Modica, Dalip Kumar, and Steven E. Rokita* “Few Constraints Limit
the Design of Quinone Methide-Oligonucleotide Self-Adducts for Directing DNA Alkylation”,
Chem. Commun. 2011, 47, 1476-1478. (DOI:10.1039/C0CC03317K).

90. Huan Wang and Steven E. Rokita* “Dynamic Cross-linking is Retained in Duplex DNA After
Multiple Exchange of Strands” Angew. Chem. Int. Ed. 2010, 49, 5957-5960.
[http://dx.doi.org/10.1002/anie.201001597]

89. Steven E. Rokita,* Jennifer M. Adler, Patrick M. McTamney and James A. Watson, Jr “Efficient
Use and Recycling of the Micronutrient Iodide in Mammals” Biochimie 2010, 92, 1227-1235.
[http://dx.doi.org/10.1016/j.biochi.2010.02.013, PMID: 20167242]

88. Neil P. Campbell, Amethist S. Finch and Steven E. Rokita* “Modulating the Ground and Excited
State Oxidation Potentials of Diaminonapthalene by Sequential N-Methylation” ChemPhysChem
2010, 11, 1768 – 1773. (http://dx.doi.org/10.1002/cphc.200900969, PMID: 20376874).

87. Patrick M. McTamney, and Steven E. Rokita* “A Mammalian Reductive Deiodinase has Broad
Power to Dehalogenate Chlorinated and Brominated Substrates” J. Am. Chem. Soc. 2009, 131,
14212–14213. (doi: 10.1021/ja906642n, PMID: 19777994) (PMCID: PMC2758933)

86. Seth R. Thomas, Patrick M. McTamney, Jennifer M. Adler, Nicole LaRonde-LeBlanc* and
Steven E. Rokita* “Crystal Structure of Iodotyrosine Deiodinase, A Novel Flavoprotein
Responsible for Iodide Salvage in Thyroid Glands” J. Biol. Chem. 2009, 284, 19659-19667.
(doi: 10.1074/jbc.M109.013458; PMCID: PMC2740591

85. Steven E. Rokita “Reversible Alkylation of DNA by Quinone Methides” in volume 1, Quinone
Methides in Chemistry and Biology of the Wiley Series on Reactive Intermediates in Chemistry
and Biology (Rokita, S.E., Ed.) Wiley, New York, 2009, p.297-327.

84. Qing Zhu, Sunita Thyagarajan, Steven E. Rokita, Kenneth D. Karlin* and Neil V. Blough*
“Hydrogen Peroxide and Dioxygen Activation by Dinuclear Copper Complexes in Aqueous
Solution: Hydroxyl Radical Production Initiated by Internal Electron Transfer” J. Am. Chem.
Soc. 2008, 130, 6304-6305.

83. James A. Watson, Jr., Patrick M. McTamney, Jennifer M. Adler, and Steven E. Rokita* “The
Flavoprotein Iodotyrosine Deiodinase Functions without Cysteine Residues” ChemBioChem
2008, 9, 504-506.

82. Huan Wang, Manvinder S. Wahi and Steven E. Rokita* “Immortalizing a Transient Electrophile
for DNA Cross-linking” Angew. Chem. Int. Ed. 2008, 47, 1291-1293. [10.1002/anie.200704137]

81. Matthew R. Holman, Takeo Ito, Steven E. Rokita* “Self-repair of Thymine Dimer in Duplex
DNA” J. Am. Chem. Soc. 2007, 129, 6-7.

80. Emily E. Weinert, Ruggero Dondi, Stefano Colloredo-Melz, Kristen N. Frankenfield, Charles H.
Mitchell, Mauro Freccero* and Steven E. Rokita* “Substituents on Quinone Methides Strongly
Modulate Formation and Stability of Their Nucleophilic Adducts” J. Am. Chem. Soc. 2006, 128,
11940-11947. [http://dx.doi.org/10.1021/ja062948k]

79. Lei Li, Narasimha N. Murthy, Joshua Telser, Lev. N. Zakharov, Glenn P. A. Yap, Arnold L.
Rheingold, Kenneth D. Karlin* and Steven E. Rokita* “Targeted Guanine Oxidation by a
Dinuclear Copper(II) Complex a Single Stranded/Double Stranded DNA Junctions” Inorg.
Chem. 2006, 45, 7144-7159.

78. Sunita Thyagarajan, N. N. Murthy, Amy Sargeant, Kenneth D. Karlin* and Steven E. Rokita*
“Selective DNA Strand Scission with Binuclear Copper Complexes: Implications for the
Involvement of a Cu2-O2 Active Species” J. Am. Chem. Soc. 2006, 128, 7003-7008.

77. Jessica E. Friedman, James A.Watson Jr., David W.-H. Lam and Steven E. Rokita*
“Iodotyrosine Deiodinase is the First Mammalian Member of the NADH Oxidase/Flavin
Reductase Superfamily” J. Biol. Chem. 2006, 281, 2812-2819.

76. Takeo Ito, Sunita Thyagarajan, Kenneth D. Karlin and Steven E. Rokita* “Recognition of
Guanines at a Double Helix-Coil Junction in DNA by a Trinuclear Copper Complex” Chem.
Commun. 2005, 4812-4814.

75. Emily E. Weinert, Kristen N. Frankenfield and Steven E. Rokita* “Time-dependent Evolution of
Adducts Formed Between Deoxynucleosides and a Model Quinone Methide”Chem. Res.
Toxicol. 2005, 18, 1364-1370. [http://dx.doi.org/10.1021/tx0501583]

74. Lei Li, Kenneth D. Karlin* and Steven E. Rokita* “Changing Selectivity of DNA Oxidation
from Deoxyribose to Guanine by Ligand Design and a New Binuclear Copper Complex” J. Am.
Chem. Soc. 2005, 127, 520-521.

73. Steven E. Rokita and Takeo Ito “Chemical Probing of Reductive Electron Transfer in DNA” in
Charge Transfer in DNA (Wagenknecht, H.-A., Ed), Wiley-VCH, Weinheim, 2005, Ch. 6, 133-151.

72. Takeo Ito and Steven E. Rokita* “Reductive Electron Injection into Duplex DNA by Aromatic
Amines” J. Am. Chem. Soc. 2004, 126, 15552-15559.

71. Dalip Kumar, Willem F. Veldhuyzen, Qibing Zhou and Steven E. Rokita* “Conjugation of a
Hairpin Pyrrole-Imidazole Polyamide to a Quinone Methide for Control of DNA Cross-linking”
Bioconj. Chem. 2004, 15, 915-922.

70. Dalip Kumar and Steven E. Rokita* “Synthesis of a Hairpin Pyrrole-Imidazole Polyamide
Conjugate Containing a Quinone Methide Precursor and Vinyl Linking Group“ Tet. Lett. 2004,
45, 2887-2889.

69. Takeo Ito and Steven E. Rokita* “Criteria for Efficient Transport of Excess Electrons in DNA”
Angew. Chem. Int. Ed. 2004, 43, 1839-1842.

68. Willem F. Veldhuyzen, Praveen Pande and Steven E. Rokita* “A Transient Product of DNA
Alkylation Can Be Stabilized by Binding Localization” J. Am. Chem. Soc. 2003, 125, 14005-
14013. [http://dx.doi.org/10.1021/ja036943o]

67. Qibing Zhou and Steven E. Rokita* “A General Strategy for Target-Promoted Alkylation in
Biological Systems” Proc. Natl. Acad. Sci. (USA) 2003, 100, 15452-15457.
[http://dx.doi.org/10.1073/pnas.2533112100]

66. Takeo Ito and Steven E. Rokita* “Excess Electron Transfer from An Internally-Conjugated
Aromatic Amine to 5-Bromo-2′-Deoxyuridine in DNA” J. Am. Chem. Soc. 2003, 125, 11480-11481.

65. William H. Walker IV and Steven E. Rokita* “Use of a Boroxazolidone Complex of 3-Iodo-LTyrosine
for Palladium-Catalyzed Cross-Coupling” J. Org. Chem. 2003, 68, 1563-1566.

64. Steven E. Rokita and Cynthia J. Burrows “Salen Metal Complexes” in Small Molecule DNA and
RNA Binders; From Synthesis to Nucleic Acid Complexes (Demeunynck, Bailly, Wilson, Eds),
Wiley-VCH, Weinheim, 2003, ch. 6, pp. 126-145.

63. Kristi J. Humphreys, Kenneth D. Karlin* and Steven E. Rokita* “Targeted Strand Scission of DNA
Substrates by a Tricopper(II) Coordination Complex” J. Am. Chem. Soc. 2002, 124, 8055-8066.

62. Kristi J. Humphreys, Anne E. Johnson, Kenneth D. Karlin* and Steven E. Rokita* “Oxidative
Strand Scission of Nucleic Acids by a Multinuclear Copper(II) Complex” J. Biol. Inorg. Chem.
2002, 7, 835-842.

61. Kristi J. Humphreys, Kenneth D. Karlin* and Steven E. Rokita* “Efficient and Specific Strand
Scission of DNA by a Binuclear Copper Complex: Comparative Reactivity of the Complexes
with Linked Tris(2-pyridylmethyl)amine Moieties” J. Am. Chem. Soc. 2002, 124, 6009-6019.

60. Willem F. Veldhuyzen, Anthony J. Shallop, Roger A. Jones and Steven E. Rokita*
“Thermodynamic versus Kinetic Products of DNA Alkylation as Modeled by Reaction of
Deoxyadenosine” J. Am. Chem. Soc. 2001, 123, 11126-11132.

59. Qibing Zhou, Praveen Pande, Anne E. Johnson and Steven E. Rokita* “Sequence-Specific
Delivery of a Quinone Methide Intermediate to the Major Groove of DNA” Bioorg. Med. Chem.
2001, 9, 2347-2354.

58. Kristi J. Humphreys, Kenneth D. Karlin* and Steven E. Rokita* “Recognition and Strand
Scission at Junctions between Single- and Double-Stranded DNA by a Trinuclear Copper
Complex” J. Am. Chem. Soc. 2001, 123, 5588-5589.

57. Willem F. Veldhuyzen, Yui-Fai Lam and Steven E. Rokita* “2-Deoxyguaninosine Reacts with
a Model Quinone Methide at Multiple Sites” Chem. Res. Toxicol. 2001, 14, 1345-1351.

56. Steven E. Rokita* “Chemical Reagents for Investigating the Major Groove of DNA” in Current
Protocols in Nucleic Acid Chemistry (G. Glick, Ed.) Wiley, New York, 2001, 6.6.1-6.6.16.

55. Steven E. Rokita* and Cynthia J. Burrows “Nickel- and Cobalt-Dependent Oxidation and
Cross-Linking of Proteins” in Metal Ions in Biological Systems vol. 38 (H. Sigel, ed.) Marcel
Dekker, New York, 2001, ch. 10, 289-311.

54. Xiang Zhou, Jason M. Shearer, and Steven E. Rokita* “A Ni(Salen)-Biotin Conjugate for
Rapid Isolation of Accessible DNA” J. Am. Chem. Soc. 2000, 122, 9046-9047.

53. Steven E. Rokita* and Cynthia J. Burrows “Structural Studies of Nucleic Acids Using Nickel
and Cobalt Based Reagents” in Current Protocols in Nucleic Acid Chemistry (G. Glick, Ed.)
Wiley, New York, 2000, 6.4.1-6.4.7.

52. Hui-Chen Shih, Helina Kassahun, Cynthia J. Burrows and Steven E. Rokita* “Selective
Association between a Macrocyclic Nickel Complex and Extrahelical Guanine Residue”
Biochemistry 1999, 38, 15034-15042.

51. Ning Tang, James G. Muller, Cynthia J. Burrows and Steven E. Rokita* “Nickel and Cobalt
Reagents Promote Selective Oxidation of Z-DNA” Biochemistry 1999, 38, 16648-16654.

50. Praveen Pande, Jason M. Shearer, Jianhong Yang, William A. Greenberg and Steven E.
Rokita*Alkylation of Nucleic Acids by a Model Quinone Methide” J. Am. Chem. Soc. 1999,
121, 6773 -6779.

49. Munetaka Kunishima, Jessica E. Friedman and Steven E. Rokita* “Transition-State Stabilization
by a Mammalian Reductive Dehalogenase” J. Am. Chem. Soc. 1999, 121, 4722-4723.

48. James Muller, Lou Anne Kayser, Sari Paikoff, Victor Duarte, Ning Tang, Ronelito Perez,
Steven E. Rokita and Cynthia J. Burrows* “Formation of DNA Adducts Using Nickel(II)
Complexes of Redox-Active Ligands: A comparison of salen and peptide complexes” Coord.
Chem. Rev. 1999, 186, 761-774.

47. Jason M. Shearer and Steven E. Rokita* “Diamine Preparation for Synthesis of a Water
Soluble Ni(II) Salen Complex” Bioorg. Med. Chem. Lett. 1999, 9, 510-504.

46. Robyn Hickerson, Victor Duarte, J. David Van Horn, Ronelito Perez, James Muller, Steven E.
Rokita, and Cynthia J. Burrows* “DNA Cleavage vs. Cross-linking using Nickel Peptides:
Mechanistic Aspects” in Metals and Genetics (B. Sarkar, Ed.), Plenum: New York, 1999,
183-196.

45. Hui-Chen Shih, Ning Tang, Cynthia J. Burrows and Steven E. Rokita* “Nickel-based Probes of
Nucleic Acid Structure Bind to Guanine but do not Perturb a Dynamic Equilibrium of
Extrahelical Guanine Residues” J. Am. Chem. Soc. 1998, 120, 3284-3288.

44. Ping Zheng, Cynthia J. Burrows and Steven E. Rokita* “Nickel- and Cobalt-Dependent
Reagents Identify Structural Features of RNA that are not Detected by Dimethyl Sulfate or
RNase T1” Biochemistry 1998, 37, 2207-2214.

43. Cynthia J. Burrows,* Ronelito J. Perez, James G. Muller and Steven E. Rokita “Oxidative DNA
Damage Mediated by Metal-Peptide Complexes” Pure and Applied Chem. 1998, 70, 275-278.

42. Nicholas Delihas,* Steven E. Rokita, and Ping Zheng “Natural Antisense RNA/target RNA
interactions–possible models for antisense oligonucleotide drug design” Nature Biotechnology
1997, 15, 751-753.

41. Steven E. Rokita*, Jianhong Yang, Praveen Pande, William A. Greenberg “Quinone Methide
Alkylation of Deoxycytidine” J. Org. Chem. 1997, 62, 3010-3012.

40. Gurpreet Gill, Angelika Richter-Rusli, Madhushree Ghosh, Cynthia J. Burrows and Steven E.
Rokita* “Nickel-Dependent Oxidative Cross-linking of a Protein” Chem. Res. Toxicol. 1997, 10,
302-309.

39. Qingping Zeng and Steven E. Rokita* “Tandem Quinone Methide Generation for Crosslinking
DNA” J. Org. Chem. 1996, 61, 9080-9081.

38. Hyunmin Kang and Steven E. Rokita* “Site-Specific and Photo-Induced Alkylation of DNA by a
Dimethylanthraquinone-Oligodeoxynucleotide Conjugate” Nucleic Acids Res. 1996, 24, 3896-3902.

37. Grant A. McLachlan, James G. Muller, Steven E. Rokita and Cynthia J. Burrows* “MetalMediated
Oxidation of Guanines in DNA and RNA: A Comparison of Cobalt(II), Nickel(II) and
Copper(II) Complexes” Inorg. Chim. Acta 1996, 251, 193-199.

36. Chien-Chung Cheng, Julia Gulia, Steven E. Rokita and Cynthia J. Burrows* “Dioxygen Chemistry
of Nickel(II) Dioxopentaazamacrocyclic Complexes: Substituent and Medium Effects” J. Mol.
Catal. 1996, 113, 379-391.

35. James G. Muller, Ping Zheng, Steven E. Rokita and Cynthia J. Burrows* “DNA Modification
Promoted by [Co(H2O)6]Cl2: Probing Temperature-Dependent Conformations” J. Am. Chem. Soc.
1996, 118, 2320-2325.

34. Cynthia J. Burrows,* James G. Muller, Gregory T. Poulter, and Steven E. Rokita “Nickel-Catalyzed
Oxidations: From Hydrocarbons to DNA” Acta Chem. Scand. 1996, 50, 337-344.

33. Cynthia J. Burrows* and Steven E. Rokita “Nickel Complexes as Probes of Guanine Sites in
Nucleic Acid Folding” in Metal Ions in Biological Systems (H. Sigel, ed.) Marcel Dekker, New
York, 1996, Ch. 18, pp. 537-560.

32. Cynthia J. Burrows,* James G. Muller, Hui-Chen Shih and Steven E. Rokita “Recognition
of B vs Z-Form DNA Using Nickel and Cobalt Complexes” in Supramolecular
Stereochemistry (J. S. Siegel, ed.), Kluwer, Dordrecht, 1995, 57-62.

31. Steven E. Rokita,* Ping Zheng, Ning Tang, Chien-Chung Cheng, Ren-Hwa Yeh, James G.
Muller, and Cynthia J. Burrows “Nickel Complexes in Modification of Nucleic Acids” in
Genetic Response to Metals (B. Sarkar, Ed.), Marcel Dekker, New York, 1995, pp 201-216.

30. Cynthia J. Burrows* and Steven E. Rokita* “Probing Guanine Structure in Nucleic Acid
Folding using Nickel Complexes” Acc. Chem. Res. 1994, 27, 295-301.

29. Tianhu Li, Qingping Zeng and Steven E. Rokita* “Target Promoted Alkylation of DNA”
Bioconj. Chem. 1994, 5, 497-500.

28. James G. Muller, Sari J. Paikoff, Steven E. Rokita* and Cynthia J. Burrows* “DNA Modification
Promoted by Water-Soluble Nickel(II) Salen Complexes: A Switch to DNA Alkylation” J.
Inorg. Biochem. 1994, 54, 199-206.

27. Moneesh Chatterjee and Steven E. Rokita* “The Role of a Quinone Methide in the Sequence
Specific Alkylation of DNA” J. Am. Chem. Soc. 1994, 116, 1690-1697.

26. Sarah A. Woodson,* James G. Muller, Cynthia J. Burrows and Steven E. Rokita “A Primer
Extension Assay for Modification of Guanine by Ni(II) Complexes” Nucleic Acids Res. 1993,
21, 5524-5525.

25. Ute Hänsler and Steven E. Rokita* “Electrostatics Rather Than Conformation Control the Oxidation
of DNA by the Anionic Reagent Permanganate” J. Am. Chem. Soc. 1993, 115, 8554-8557.

24. Xiaoying Chen, Sarah A. Woodson, Cynthia J. Burrows* and Steven E. Rokita* “A Highly
Sensitive Probe for Guanine N7 in Folded Structures of RNA: Application to tRNAphe and
Tetrahymena Group I Intron” Biochemistry 1993, 32, 7610-7616.

23. James G. Muller, Xiaoying Chen, Adonis C. Dadiz, Steven E. Rokita* and Cynthia J. Burrows*
“Macrocyclic Nickel Complexes in DNA Recognition and Oxidation” Pure and Applied Chem.
1993, 65, 545-550.

22. Chien-Chung Cheng, Steven E. Rokita* and Cynthia J. Burrows* “Nickel(III)-Promoted
DNA Scission Using Ambient Dioxygen” Angew. Chem. Int. Ed. 1993, 32, 277-278.

21. Steven E. Rokita* and Lorraine Romero-Fredes “The Ensemble Reactions of Hydroxyl
Radical Exhibit No Specificity for Primary or Secondary Structure of DNA” Nucleic Acids
Res. 1992, 20, 3069 – 3072.

20. James G. Muller, Xiaoying Chen, Adonis C. Dadiz, Steven E. Rokita* and Cynthia J.
Burrows* “Ligand Effects Associated with the Intrinsic Selectivity of DNA Oxidation
Promoted by Nickel(II) Macrocyclic Complexes” J. Am. Chem. Soc. 1992, 114, 6407 – 6411.

19. Xiaoying Chen, Cynthia J. Burrows* and Steven E. Rokita* “Conformation Specific Detection
of Guanosine in DNA: Ends, Mismatches, Bulges and Loops” J. Am. Chem. Soc. 1992, 114,
322 – 325.

18. John E. Butler-Ranshoff, Steven E. Rokita, Debra A. Kendall, Jennifer A. Banzon, Kristin
S. Carano, Emil Thomas Kaiser and Albert R. Matlin* “Active-Site Mutagenesis of E. coli
Alkaline Phosphatase: Replacement of Serine-102 with Non-Nucleophilic Amino Acids”
J. Org. Chem. 1992, 57, 142 – 145.

17. Tianhu Li and Steven E. Rokita* “Selective Modification of DNA Controlled by an Ionic
Signal” J. Am. Chem. Soc. 1991, 113, 7771 – 7773.

16. Xiaoying Chen, Steven E. Rokita* and Cynthia J. Burrows* “DNA Modification: Intrinsic
Selectivity of Nickel(II)-Complexes” J. Am. Chem. Soc. 1991, 113, 5884 – 5886.

15. Moneesh Chatterjee and Steven E. Rokita* “Sequence Specific Alkylation of DNA Activated by
an Enzymatic Signal” J. Am. Chem. Soc. 1991, 113, 5116 – 5117.

14. Elisa M. Woolridge and Steven E. Rokita* “The Use of 6-(Difluoromethyl)indole to Study the
Activation of Indole by Tryptophan Synthase” Arch. Biochem. Biophys. 1991, 286, 473 – 480.

13. Elisa M. Woolridge and Steven E. Rokita* “6-(Difluoromethyl)tryptophan as a Probe for
Substrate Activation During the Catalysis of Tryptophanase” Biochemistry 1991, 30, 1852-1857.

12. Moneesh Chatterjee and Steven E. Rokita* “A Quinone Based Method for Inducible Alkylation
of DNA at Predetermined Sequences” J. Am. Chem. Soc. 1990, 112, 6397 – 6399.

11. Steven E. Rokita*, Stacey Prusiewicz and Lorraine Romero-Fredes “The Effect of Ionic Strength
on the Photosensitized Oxidation of d(CG)6” J. Am. Chem. Soc. 1990, 112, 3616 – 3621.

10. Steven E. Rokita*, Bernard Lau and Lorraine Romero-Fredes “Structural Dependence of
Oligonucleotide Photooxidation” Biopolymers 1990, 29, 69 – 77.

9. Steven E. Rokita* and Lorraine Romero-Fredes “Facile Interconversion of Duplex Structures
Formed by Copolymers of d(CG)” Biochemistry 1989, 28, 9674 – 9679.

8. Elisa M. Woolridge and Steven E. Rokita* “Synthesis and Reactivity of 6-(Fluoromethyl)indole
and 6-(Difluoromethyl)indole” Tet. Lett. 1989, 30, 6117 – 6120.

7. Xiaoyan Ma and Steven E. Rokita* “Role of Oxygen During Horseradish Peroxidase Turnover
and Inactivation” Biochem. Biophys. Res. Commun. 1988, 157, 160 – 165.

Publications prior to beginning independent career:

6. Steven E. Rokita and E. T. Kaiser* “Flavolysozyme, a New Semi-Synthetic Enzyme” J. Am. Chem.
Soc. 1986, 108, 4984 – 4987.

5. Soumitra S. Ghosh, Susan C. Bock, Steven E. Rokita and E. T. Kaiser* “Modification of the Active
Site of Alkaline Phosphatase by Site-Directed Mutagenesis” Science 1986, 231, 145 – 148.

4. E. T. Kaiser*, David S. Lawrence and Steven E. Rokita “The Chemical Modification of
Enzymatic Specificity” Ann. Rev. in Biochemistry 1985, 54, 565 – 595.

3. Steven E. Rokita* and Christopher T. Walsh “Flavin and 5-Deazaflavin Photosensitized
Cleavage of Thymine Dimer: A Model of in Vivo Light-Requiring DNA Repair” J.
Am. Chem. Soc. 1984, 106, 4589 – 4595.

2. Steven E. Rokita and Christopher T. Walsh* “Turnover and Inactivation of Bacterial
Citrate Lyase with 2-Fluorocitrate and 2-Hydroxycitrate Stereoisomers” Biochemistry
1983, 22, 2821 – 2828.

1. Steven E. Rokita, Paul Srere and Christopher T. Walsh* “3-Fluoro-3-deoxycitrate: A Probe
for the Mechanistic Study of Citrate Utilizing Enzymes” Biochemistry 1982, 21, 3765 – 3774.