Mechanistic Studies on RNA Strand Scission From a C2′-Radical. Paul, R.; Greenberg, M. M. J. Org. Chem. 2016, 81, 9199-9205.
Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase. Pidugu, L. S.; Flowers, J.; Coey, C. T.; Pozharski, E.; Greenberg, M. M.; Drohat, A. C. Biochemistry 2016, 53, 6205-6208.
Probing Enhanced Double Strand Break Formation at Abasic Sites Within Clustered Lesions in Nucleosome Core Particles. Banerjee, S.; Chakraborty, S.; Jacinto, M. P.; Paul, M. D.; Balster, M. V.; Greenberg, M. M. Biochemistry 2017, 54, 14-21. (PMC: 5372979)
Identification of Proximal Sites for Partially Unwound DNA Substrate in Escherichia coli Topoisomerase I With Oxidative Crosslinking. Cheng, B.; Zhou, Q.; Weng, L.; Leszyk, J. D.; Greenberg, M. M.; Tse-Dinh, Y. FEBS Lett. 2017, 591, 28-38. (PMC: 5235945)
Aminyl Radical Generation via Tandem Norrish Type I Photocleavage, -Fragmentation: Independent Generation and Reactivity of the 2′-Deoxyadenosin-N6-yl Radical. Zheng, L.; Griesser, M.; Pratt, D. A.; Greenberg, M. M. J. Org. Chem. 2017, 82, 3571-3580. (PMC: 5494259)
Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones. Zhang, Y.; Zhou, X.; Xie, Y.; Greenberg, M. M.; Xi, Z.; Zhou, C. J. Am. Chem. Soc. 2017, 139, 6146-6151. (PMC: 5491101)
EC-Tagging Allows Cell Type-Specific RNA Analysis. Hida, N.; Aboukilila, M. Y.; Burow, D. A.; Paul, R.; Greenberg, M. M.; Fazio, M.; Beasley, S.; Spitale, R. C.; Cleary, M. D. Nucleic Acids Res. 2017, 45, e138.
The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase Theta. Laverty, D. J.; Averill, A. M.; Doublié, S.; Greenberg, M. M. ACS Chem. Biol. 2017, 12, 1584-1592. (PMC: 5499511)
Synergistic Effects of an Irreversible DNA Polymerase Inhibitor and DNA Damaging Agents on HeLa Cells. Paul, R.; Banerjee, S.; Greenberg, M. M. ACS Chem. Biol. 2017, 12, 1576-1583. (PMC: 5492961) (Highlighted (“Spotlight”) in Chem. Res. Toxicol. 2017, 30, 1367-1368.)
5-Formylcytosine Yields DNA-Protein Crosslinks in Nucleosome Core Particles. Li, F.; Zhang, Y.; Bai, J.; Greenberg, M. M.; Xi, Z.; Zhou, C. J. Am. Chem. Soc. 2017, 139, 10617-10620.
Independent Generation and Reactivity of Thymidine Radical Cations. Sun, H.; Taverna Porro, M. L.; Greenberg, M. M. J. Org. Chem. 2017, 82, 11072-11083.
DNA Damage Emanating From a Neutral Purine Radical Reveals the Sequence Dependent Convergence of the Direct and Indirect Effects of -Radiolysis. Zheng, L.; Greenberg, M. M. J. Am. Chem. Soc. 2017, 139, 17751-17754.
Independent Photochemical Generation and Reactivity of Nitrogen-Centered Purine Nucleoside Radicals From Hydrazines. Zheng, L.; Lin, L.; Qu, K.; Adhikary, A.; Sevilla, M. D.; Greenberg, M. M. Org. Lett. 2017, 19, 6444-64447.
In Vitro Pol Theta Bypass of Thymidine Glycol Forms Sequence-Dependent Frameshift Mutations. Laverty, D. J.; Greenberg, M. M. Biochemistry 2017, 56, 6726-6733.
An Oxidized Abasic Lesion Inhibits Base Excision Repair Leading to DNA Strand Breaks in a Trinucleotide Repeat Tract. Beaver, J. M.; Lai, Y.; Rolle, S. J.; Weng, L.; Greenberg, M. M.; Liu, Y. PLoS ONE 13(2): e0192148. https://doi.org/10.1371/journal.pone.0192148 (PMC: 5794147)
Traceless Tandem Lesion Formation in DNA From a Nitrogen-Centered Purine Radical. Zheng, L.; Greenberg, M. M. J. Am. Chem. Soc. 2018, 140, 6400-6407. (PMC: 5966344)
Mechanistic Insight Through Irreversible Inhibition: DNA Polymerase Uses a Common Active Site for Polymerase and Lyase Activities. Laverty, D. J.; Mortimer, I. P.; Greenberg, M. M. J. Am. Chem. Soc. 2018, 140, 9034-9037.
Rotational Effects Within Nucleosome Core Particles on Abasic Site Reactivity. Wang, R.; Yang, K.; Banerjee, S.; Greenberg, M. M. Biochemistry 2018, 57, 3945-3952.
Independent Generation of Reactive Intermediates Leads to an Alternative Mechanism for Strand Damage Induced by Hole Transfer in Poly•(dA-T) Sequences. Sun, H.; Zheng, L.; Greenberg, M. M. J. Am. Chem. Soc. 2018, 140, 11308-11316.
Enhanced Cleavage at Abasic Sites Within Clustered Lesions in Nucleosome Core Particles. Yang, K.; Greenberg, M. M. ChemBioChem 2018, 19, 2061-2065. Designated as a Very Important Paper (VIP) by the Editor.
Facile Synthesis of 5-Methylene-2-pyrrolones. Jacinto, M. P.; Pichling, P.; Greenberg, M. M. Org. Lett. 2018, 20, 4885-4887.
Expanded Substrate Scope of DNA Polymerase Theta and DNA Polymerase Beta: Lyase Activity on 5′-Overhangs and Clustered Lesions. Laverty, D. J.; Greenberg, M. M. Biochemistry 2018, 57, 6119-6127. (PMC: 6200648)
Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Leads to Substantial DNA-Histone Cross-links Within Nucleosome Core Particles. Bai, J.; Zhang, Y.; Xi, Z.; Greenberg, M. M.; Zhou, C. Chem. Res. Toxicol. 2018, 31, 1364-1372.
Histone Tails Decrease N7-Methyl-2′-Deoxyguanosine Depurination and Yield DNA-Protein Crosslinks in Nucleosome Core Particles and Cells. Yang, K.; Park, D.; Tretyakova, N. Y.; Greenberg, M. M. Proc. Natl. Acad. Sci. USA 2018, 115, E11212-E11220. Highlighted in Chemical & Engineering News (https://cen.acs.org/biological-chemistry/nucleic-acids/Chemicals-cause-unexpected-DNA-damage/96/i48) and by the NIEHS.
Histone Tail Sequences Balance Their Role in Genetic Regulation and the Need to Protect DNA Against Destruction in Nucleosome Core Particles Containing Abasic Sites. Yang, K.; Greenberg, M. M. ChemBioChem 2019, 20, 78-82.
A Guardian Residue Hinders Insertion of a Fapy•dGTP Analog by Modulating the Open-Closed DNA Polymerase Transition. Smith, M. R.; Shock, D. D.; Beard, W. A.; Greenberg, M. M.; Freudenthal, B. D.; Wilson, S. H. Nucleic Acids Res. 2019, 47, 3197-3207.
Reactivity of the Major C5′-Oxidative DNA Damage Product in Nucleosome Core Particles. Rana, A.; Yang, K.; Greenberg, M. M. ChemBioChem 2019, 20, 672-676. Designated as a Very Important Paper (VIP) by the Editor.
Effect of Histone Lysine Methylation on DNA Lesion Reactivity in Nucleosome Core Particles.Yang, K.; Prasse, C.; Greenberg, M. M. Chem. Res. Toxicol. 2019, 32, 910-916. Invited article for special issue: Epigenetics in Toxicology.
Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles. Sun, H.; Zheng, L.; Yang, K.; Greenberg, M. M. J. Am. Chem. Soc. 2019, 141, 10154-10158.
Reactivity of 3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles.Yang, K.; Sun, H.; Lowder, L.; Varadarajan, S.; Greenberg, M. M. Chem. Res. Toxicol. 2019, 32, 2118-2124. Selected to be Editor’s Choice by the American Chemical Society; September 30, 2019.
DNA-Protein Cross-link Formation in Nucleosome Core Particles Treated with Methyl Methanesulfonate. Yang, K.; Greenberg, M. M. Chem. Res. Toxicol. 2019, 32, 2144-2151.
Mutagenic Effects of a 2-Deoxyribonolactone – Thymine Glycol Tandem Lesion in Human Cells. Naldiga, S.; Huang, H.; Greenberg, M. M.; Basu, A. K. Biochemistry 2020, 59, 417-424.
Solid-Phase Synthesis of Oligonucleotides Containing the N6-(2-Deoxy-a,b-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy•dG) Oxidative Damage Product Derived from 2′-Deoxyguanosine. Yang, H.; Tang, J. A.; Greenberg, M. M. Chem. – Eur. J. 2020, 26, 5441 – 5448. Designated by the editor as a Hot Paper.
Light-Controlled Twister Ribozyme With Single Molecule Detection Resolves RNA Function in Time and Space. Korman, A.; Sun, H.; Hua, B.; Yang, H.; Capilato, J. N.; Paul, R.; Panja, S.; Ha, T.; Greenberg, M. M.; Woodson, S. A. Proc. Natl. Acad. Sci. USA 2020, 117, 12080-12086.
Independent Generation and Time-Resolved Detection of 2′-Deoxyguanosin-N2-yl Radicals. Zheng, L.; Dai, X.; Su, H.; Greenberg, M. M. Angew. Chem. Int. Ed. 2020, 59, 13406-13413. Designated by the editor as a Hot Paper.
Independent Generation and Reactivity of 2’-Deoxyguanosin-N1-yl Radical. Zheng, L.; Greenberg, M. M. J. Org. Chem. 2020, 85, 8665-8672.