The Knierim Lab studies the behavioral and cognitive correlates of the hippocampal formation—a brain region that is critical for forming and storing long-term memories. Read more about our research.
Congratulations to Ravi, Manu, and Francesco for Nature paper
March 24, 2019: In collaboration with the LIMBS lab of Noah Cowan (JHU Mechanical Engineering) and the lab of Tad Blair (UCLA), we recently published a paper in Nature showing that the path integration system has a dynamic gain variable that can be recalibrated with experience. We used an augmented reality system to produce a continuous conflict between self-motion cues and visual landmarks, in that rotation of the landmarks produced an illusion that the rat ws running faster or slower than it really was. When we subsequently turned the landmarks off, we showed that CA1 place cells had recalibrated the rate at which they updated the rat’s position based on path integration.
Cheng and Xiaojing publish Science paper
March 24, 2019: Last fall, we published a paper in Science showing that the lateral entorhinal cortex represented the location of the rat in an egocentric framework relative to external locations or items. This result confirms predictions from a model that the LEC encodes the locations of “other” items in the environment from a first-person perspective, as opposed to the MEC, which encodes the position of the “self” in allocentric coordinates. The egocentric coding of LEC is consistent with the notion that the LEC provides the hippocampus with information about the content of an episode, in accordance with the first-person perspective that characterizes episodic memories.
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