Publications

Chen, X., Rajasekaran, N., Liu, K., & Kaiser, C. M. (2020). Synthesis runs counter to the directional folding pathway of a nascent protein domain. (in revision)
Nature Communications (in press)
(bioRxiv: 2020.04.29.068593)

Gupta, R., Toptygin, D., & Kaiser, C. M. (2020). The SecA motor generates mechanical force during protein translocation. Nature Communications 11(1): 3802

Bustamante, C., Alexander, L., Maciuba, K. & Kaiser C. M. (2020). Single-Molecule Studies of Protein Folding with Optical Tweezers. Annual Review of Biochemistry 89:443-470

Liu, K., Chen, X., & Kaiser, C. M. (2019). Energetic dependencies dictate folding mechanism in a complex protein. Proceedings of the National Academy of Sciences of the United States of America, 116(51), 25641-25648.

Liu, K., Maciuba, K., & Kaiser, C. M. (2019). The Ribosome Cooperates with a Chaperone to Guide Multi-domain Protein Folding. Molecular Cell, 74(2), 310-319.e7.

Kaiser, C. M., & Liu, K. (2018). Folding up and Moving on—Nascent Protein Folding on the Ribosome. Journal of Molecular Biology, 430(22), 4580–4591.

Liu, K., Rehfus, J. E., Mattson, E., & Kaiser, C. M. (2017). The ribosome destabilizes native and non-native structures in a nascent multidomain protein. Protein Science, 26(7), 1439–1451.

Motlagh, H. N., Toptygin, D., Kaiser, C. M., & Hilser, V. J. (2016). Single-Molecule Chemo-Mechanical Spectroscopy Provides Structural Identity of Folding Intermediates. Biophysical Journal, 110(6), 1280–1290.

Goldman, D. H., Kaiser, C. M., Milin, A., Righini, M., Tinoco, I., & Bustamante, C. (2015). Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivo. Science, 348(6233), 457–460.

Kaiser, C. M., & Tinoco, I. (2014). Probing the Mechanisms of Translation with Force. Chemical Reviews, 114(6), 3266–3280.

Bustamante, C. J., Kaiser, C. M., Maillard, R. A., Goldman, D. H., & Wilson, C. A. M. (2014). Mechanisms of Cellular Proteostasis: Insights from Single-Molecule Approaches. Annual Review of Biophysics, 43(1), 119–140.

Previous work

Kaiser, C. M., Bujalowski, P. J., Ma, L., Anderson, J., Epstein, H. F., & Oberhauser, A. F. (2012). Tracking UNC-45 Chaperone-Myosin Interaction with a Titin Mechanical Reporter. Biophysical Journal, 102(9), 2212–2219.

Kaiser, C. M., Goldman, D. H., Chodera, J. D., Tinoco, I., & Bustamante, C. (2011). The Ribosome Modulates Nascent Protein Folding. Science, 334(6063), 1723–1727.

Maillard, R. A., Chistol, G., Sen, M., Righini, M., Tan, J., Kaiser, C. M., … Bustamante, C. (2011). ClpX(P) Generates Mechanical Force to Unfold and Translocate Its Protein Substrates. Cell, 145(3), 459–469.

Lakshmipathy, S. K., Tomic, S., Kaiser, C. M., Chang, H.-C., Genevaux, P., Georgopoulos, C., … Etchells, S. A. (2007). Identification of Nascent Chain Interaction Sites on Trigger Factor. Journal of Biological Chemistry, 282(16), 12186–12193.

Kaiser, C. M., Chang, H.-C., Agashe, V. R., Lakshmipathy, S. K., Etchells, S. A., Hayer-Hartl, M., … Barral, J. M. (2006). Real-time observation of trigger factor function on translating ribosomes. Nature, 444(7118), 455–460.

Chang, H.-C., Kaiser, C. M., Hartl, F. U., & Barral, J. M. (2005). De novo Folding of GFP Fusion Proteins: High Efficiency in Eukaryotes but Not in Bacteria. Journal of Molecular Biology, 353(2), 397–409.