{"id":745,"date":"2025-11-10T15:50:33","date_gmt":"2025-11-10T15:50:33","guid":{"rendered":"https:\/\/sites.krieger.jhu.edu\/xray\/?page_id=745"},"modified":"2025-12-10T13:49:31","modified_gmt":"2025-12-10T13:49:31","slug":"rigaku-xtalab-synergy-r","status":"publish","type":"page","link":"https:\/\/sites.krieger.jhu.edu\/xray\/rigaku-xtalab-synergy-r\/","title":{"rendered":"Rigaku XtaLAB Synergy-R (Cu)"},"content":{"rendered":"\n
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\u201cAll we have discovered is that it starts with a single individual \u2013 always a child \u2013 and then spreads explosively, like the formation of crystals round the first nucleus in a saturated solution.\u201d<\/em> Arthur C. Clarke (Childhood\u2019s End, 1953)<\/p>\n<\/blockquote>\n\n\n\n\n \n
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XtaLAB Synergy-R built around the PhotonJet-R rotating anode X-ray source (Cu)\n <\/td>\n <\/tr>\n<\/table>\n\n\n\n

The Rigaku XtaLab Synergy-R<\/strong> is a high-flux rotating-anode single-crystal X-ray diffractometer that combines speed, sensitivity, and reliability for advanced crystallographic research. Configured with a Cu K\u03b1 radiation source, it delivers an intense, stable X-ray beam ideally suited for challenging small-molecule and macromolecular samples. This configuration enhances anomalous scattering, improves contrast for lighter elements, and enables the collection of high-quality data from microcrystals that are otherwise difficult to measure. The microfocus Cu rotating-anode used in the Synergy-R (PhotonJet-R \/ MicroMax-007 HF) runs at 1.2 kW (1200 W). This system can produce up to 30\u00d7 the flux compared compared with the microfocus Cu sealed-tube source from the SuperNova system.<\/strong><\/p>\n\n\n\n

If you are working with challenging crystals or need to maximize the capabilities of single-crystal X-ray analysis, the Rigaku XtaLAB Synergy-R equipped with a Cu rotating anode offers a significant performance advantage. Contact the X-ray facility manager<\/a> to discuss your samples, request example datasets, or arrange a demonstration and trial with your own crystals. We will work with you to determine the most effective data-collection strategy and the outcomes you can expect.<\/p>\n\n\n\n

The instrument is particularly valuable for the following types of samples:<\/p>\n\n\n\n

    \n
  1. Tiny crystals<\/strong> \u2013 Samples with crystal dimensions of ~ 10\u201340 \u03bcm. The Synergy-R\u2019s powerful Cu source allows accurate and complete data collection from such small samples.<\/li>\n\n\n\n
  2. Weakly diffracting or complex materials<\/strong> \u2013 Structures that exhibit poor long-range order or contain substantial solvent inclusion (e.g.<\/em>, metal\u2013organic frameworks and supramolecular assemblies) often produce weak diffraction. The Synergy-R significantly improves data resolution and quality, enabling reliable structure determination suitable for publication.<\/li>\n\n\n\n
  3. Protein crystals with long unit-cell dimensions<\/strong> \u2013 Protein crystals with extended unit cells (~ 150 \u00c5 or longer) exceed the capabilities of our existing SuperNova system, limited by its fixed beam divergence (4.5 mrad) and lower flux. The Synergy-R\u2019s high-intensity source and optimized optics overcome these constraints, facilitating complete and precise data collection for such systems.<\/li>\n<\/ol>\n\n\n\n

    Key Benefits<\/h2>\n\n\n\n
    \n\n\n\n

    \u2022 Exceptional sensitivity for micro-crystals<\/strong>: Obtain usable diffraction from crystals that would be invisible on lower-power instruments.
    \u2022 Improved anomalous signal<\/strong>: Cu K\u03b1 wavelength enhances anomalous scattering for many light-to-medium elements, aiding absolute configuration and element identification.
    \u2022 Faster collections, higher throughput<\/strong>: Greater photon flux supports both reduced exposure times and enhanced data redundancy, all without compromising data quality.
    \u2022 Robust, reproducible results<\/strong>: Stable beam and modern detector technologies ensure consistent datasets suitable for publication and deposit.
    \u2022 Versatile sample compatibility<\/strong>: inorganics,* organics, organometallics, coordination complexes, supramolecular complex, protein crystals and weakly diffracting materials.
    * Crystals should be very small\u2014ideally 10\u201320 \u00b5m in each dimension\u2014to reduce absorption effects. Using the Synergy-R Cu configuration, a maximum resolution of approximately 0.79 \u00c5 can be achieved.<\/em><\/p>\n\n\n\n

    Technical Highlights<\/h2>\n\n\n\n
    \n\n\n\n

    \u2022 Cu rotating-anode X-ray source<\/strong>: high-power (1.2 kW), stable Cu K\u03b1 radiation (\u03bb \u2248 1.5418 \u00c5) optimized for anomalous studies and contrast of light elements.
    \u2022 Advanced hybrid photon-counting detector HyPix-6000HE<\/strong> for fast readout, low noise and high dynamic range.
    \u2022 Integrated low-temperature cryo-device Oxford Cryostream 1000<\/strong> for temperature-dependent studies (temperature range: 80-400 K) and radiation-damage mitigation.
    \u2022 Integrated into the variable-beam optics, the slit mechanism<\/strong> regulates the beam width, shape, and divergence, giving users fine control to match the beam to the sample and experiment.
    \u2022 CrysAlisPro <\/strong>offers automated experiment planning, real-time data processing (single, twinning, mult-crystal), advanced absorption corrections, and seamless export to all major refinement packages.<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u201cAll we have discovered is that it starts with a single individual \u2013 always a child \u2013 and then spreads explosively, like the formation of crystals round the first nucleus in a saturated solution.\u201d Arthur C. Clarke (Childhood\u2019s End, 1953) XtaLAB Synergy-R built around the PhotonJet-R rotating anode X-ray source (Cu) The Rigaku XtaLab Synergy-R is […]<\/p>\n","protected":false},"author":688,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-745","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/pages\/745","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/users\/688"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/comments?post=745"}],"version-history":[{"count":5,"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/pages\/745\/revisions"}],"predecessor-version":[{"id":962,"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/pages\/745\/revisions\/962"}],"wp:attachment":[{"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/media?parent=745"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}