{"id":7,"date":"2025-08-14T15:25:01","date_gmt":"2025-08-14T15:25:01","guid":{"rendered":"https:\/\/sites.krieger.jhu.edu\/xray\/?page_id=7"},"modified":"2025-12-10T14:00:57","modified_gmt":"2025-12-10T14:00:57","slug":"service-pricing","status":"publish","type":"page","link":"https:\/\/sites.krieger.jhu.edu\/xray\/service-pricing\/","title":{"rendered":"Services\/Pricing"},"content":{"rendered":"\n
\n

\u201cAll we have discovered is that it starts with a single individual \u2013 always a child \u2013 and then spreads explosively, like the formation of crystals round the first nucleus in a saturated solution.\u201d<\/em> Arthur C. Clarke (Childhood\u2019s End, 1953)<\/p>\n<\/blockquote>\n\n\n\n

Our customer service approach is straightforward: we strive to be friendly, respectful, and professional in every interaction. All users\u2014whether from Johns Hopkins University or external institutions\u2014receive the same high standard of service.<\/p>\n\n\n\n

We are committed to providing expert guidance, high-quality results, and timely feedback on submitted samples. Services can be tailored to meet specific research needs, and we welcome submissions from both academic and non-academic institutions. Confidentiality agreements can be arranged upon request. For non-JHU users, please contact the X-ray Facility Manager at xray@jhu.edu<\/a> to discuss your requirements and obtain a cost estimate. We also actively welcome opportunities for scientific collaboration<\/strong>.<\/p>\n\n\n\n

Services<\/h2>\n\n\n\n
\n\n\n\n
    \n
  • Small-Molecule Crystallography<\/strong>
    Single-crystal X-ray diffraction analysis and full structure determination of a wide range of compounds, including organic, inorganic, organometallic, coordination complexes, and metal\u2013organic frameworks (MOFs).<\/li>\n\n\n\n
  • Protein Crystallography<\/strong>
    Crystal screening and optimized X-ray data collection for protein crystals<\/li>\n\n\n\n
  • Specialized Sample Handling<\/strong>
    Expertise with air-, moisture-, and temperature-sensitive samples.<\/li>\n\n\n\n
  • Crystal Quality Assessment<\/strong>
    Inspection under a polarizing stereo microscope; evaluation under a nitrogen cold stream for unstable samples.<\/li>\n\n\n\n
  • Database Searches<\/strong>
    Identification of known compounds via the Cambridge Structural Database (CSD).<\/li>\n\n\n\n
  • Low-Temperature Data Collection<\/strong>
    Standard measurements at 110 K using either Mo K\u03b1 or Cu K\u03b1 radiation; redundant data typically 6\u201310-fold (higher redundancy available on request).<\/li>\n\n\n\n
  • Variable-Temperature Studies<\/strong>
    Semi-automated measurement of unit cell parameters and crystal structures across a controlled temperature range of 100\u2013300 K (precision \u00b1 0.1 K). These studies enable the investigation of temperature-dependent structural changes, such as phase transitions, thermal expansion\/contraction, and variations in molecular packing, providing valuable insights into material stability and behavior under different thermal conditions.<\/li>\n\n\n\n
  • Crystal Imaging<\/strong>
    Recording of JPEG crystal movies, useful for crystal face indexing.<\/li>\n\n\n\n
  • Absorption Corrections<\/strong>
    Analytical numeric absorption correction using multifaceted crystal models.<\/li>\n\n\n\n
  • Structure Determination<\/strong>
    Comprehensive structure solution and refinement, including challenging cases such as disordered, twinned, high-Z\u2032<\/em>, pseudosymmetric, and commensurately modulated structures.<\/li>\n\n\n\n
  • Absolute Structure Determination<\/strong>
    Determination of absolute configuration for enantiopure compounds, including those composed exclusively of light atoms (e.g.<\/em>, molecules containing only oxygen as the heaviest atom).<\/li>\n\n\n\n
  • Special Topics of Interest<\/strong>
    Polymorphism (screening and analysis), solid\u2013solid phase transitions, solvates, and co-crystals.<\/li>\n\n\n\n
  • Final Deliverables<\/strong>
    Edited CIF file, experimental report, ORTEP plot(s), data files, and supporting documentation.<\/li>\n\n\n\n
  • Consulting and Support<\/strong>
    Expert advice, consultancy, and interpretation of structural results.<\/li>\n<\/ul>\n\n\n\n

    Pricing<\/h2>\n\n\n\n
    \n\n\n\n\n \n \n \n \n \n
    (as of 09\/02\/2025)<\/div><\/td>\n
    		\n
    JHU<\/strong><\/div><\/td>\n
    		\n
    non-JHU Academic<\/strong><\/div><\/td>\n
    		\n
    non-Academic<\/strong><\/div><\/td>\n <\/tr>\n
    \n
    Package I<\/strong><\/div><\/td>\n
    		\n
    $10.00 per hour<\/div><\/td>\n
    		\n
    $15.00 per hour<\/div><\/td>\n
    		\n
    $40.00 per hour<\/div><\/td>\n <\/tr>\n
    \n
    Package II<\/strong><\/div><\/td>\n
    		\n
    $30.00<\/div><\/td>\n
    		\n
    $37.00<\/div><\/td>\n
    		\n
    $106.00<\/div><\/td>\n <\/tr>\n
    \n
    Package III<\/strong><\/div><\/td>\n
    		\n
    $122.00<\/div><\/td>\n
    		\n
    $138.00<\/div><\/td>\n
    		\n
    $318.00<\/div><\/td>\n <\/tr>\n
    \n
    Package IV<\/strong><\/div><\/td>\n
    		\n
    $249.00<\/div><\/td>\n
    		\n
    $292.00<\/div><\/td>\n
    		\n
    $716.00<\/div><\/td>\n <\/tr>\n <\/table>\n\n\n\n

    Package I<\/h3>\n\n\n\n

    This package covers crystal screening<\/strong> and is limited to protein X-ray crystallography<\/strong>. The purpose of crystal screening is to:
    (i) Distinguish whether the sample is a protein crystal or a salt.
    (ii) Assess the diffraction quality, including the maximum achievable resolution.
    Note<\/em>: Unit cell determination is not included in this package.<\/p>\n\n\n\n

    Package II<\/h3>\n\n\n\n

    This package includes unit cell determination<\/strong> and optional crystal face indexing<\/strong>. Diffraction intensities are typically measured at 110 K<\/strong> (adjustable between 80\u2013400 K if required). A CSD (Cambridge Structural Database) search<\/strong> can be typically performed to determine whether the crystal structure has been previously reported or is novel. Results and supporting files are delivered via email the same day.
    Expected workload<\/em>:<\/strong> typically under 15 minutes.<\/p>\n\n\n\n

    Package III<\/h3>\n\n\n\n

    This package builds on Package II, adding data collection\/reduction<\/strong> and analytical absorption corrections<\/strong>. Crystal face indexing is also included. Intensities are typically measured at 110 K<\/strong> (adjustable between 80\u2013400 K if required). Data are collected to a resolution of 0.77\u20130.84 \u00c5<\/strong>, or higher if necessary. Results, including the .HKL data file<\/strong> and additional files, are provided via<\/em> email within the same (or next) business day.
    Expected workload<\/em>: same business day; next business day at the latest.<\/p>\n\n\n\n

    Package IV<\/h3>\n\n\n\n

    This package includes everything in Package III, plus structure solution and refinement<\/strong>. A finalized set of results and files is provided as a ZIP package<\/strong> via<\/em> email.
    Expected workload<\/em>: same day for straightforward structures, several days for more complex or challenging cases.<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u201cAll we have discovered is that it starts with a single individual \u2013 always a child \u2013 and then spreads explosively, like the formation of crystals round the first nucleus in a saturated solution.\u201d Arthur C. Clarke (Childhood\u2019s End, 1953) Our customer service approach is straightforward: we strive to be friendly, respectful, and professional in every […]<\/p>\n","protected":false},"author":302,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-7","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/pages\/7","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/users\/302"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/comments?post=7"}],"version-history":[{"count":5,"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/pages\/7\/revisions"}],"predecessor-version":[{"id":968,"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/pages\/7\/revisions\/968"}],"wp:attachment":[{"href":"https:\/\/sites.krieger.jhu.edu\/xray\/wp-json\/wp\/v2\/media?parent=7"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}