243. Knox, EJ; Sinner, EK; Townsend, CA; Boal, SJ; Booker, SJ.; Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis. Nature. 2022, 602, 343-348, 10.1038/s41586-021-04392-4.

242. Sinner, E.K.; Marous, D.R.; Townsend, C.A.; Evolution of Methods for the Study of Cobalamin-Dependent Radical SAM Enzymes. ACS Bio Med Chem Au. 2021, 10.1021/acsbiomedchemau.1c00032.

241. Zandi, T.A.; Townsend, C.A.; Competing off-loading mechanisms of meropenem from an L,D-transpeptidase reduce antibiotic effectiveness. PNAS. 2021, 118 (27), 10.1073/pnas.2008610118.

240. Long, D.H.; Townsend, C.A.; Acyl Donor Stringency and Dehydroaminoacyl Intermediates in β‑Lactam Formation by a Non-ribosomal Peptide Synthetase. ACS Chem. Biol. 2021, 16, 806-812.

239. Wheadon, M.J.; Townsend, C.A.; Evolutionary and functional analysis of an NRPS condensation domain integrates β-lactam, D-amino acid, and dehydroamino acid synthesis. PNAS. 2021, 118 (17), 10.1073/pnas.2026017118.

238. Batchelder, H.R.; Story-Roller, E.; Lloyd, E.P.; Kaushik, A; Bigelow, K.M.; Maggioncalda, E.M.; Nuermberger, E.L.; Lamichhane, G.; Townsend, C.A.; Development of a penem antibiotic against Mycobacteroides abscessus. Commun. Biol. 3, 741 (2020). 10.1038/s42003-020-01475-2.

237. Cohen, D. R.; Townsend, C. A.; C-N Coupled Metabolites Yield Insights into Dynemicin A Biosynthesis. ChemBioChem. 2020, 10.1002/cbic.202000177.

236. Sinner, E. K.; Lichstrahl, M. S.; Li, R.; Marous, D. R.; Townsend, C. A.; Methylations in complex carbapenem biosynthesis are catalyzed by a single cobalamin-dependent radical S-adenosylmethionine enzyme. Chem. Commun. 2019, 55 (99), 14934-14937.

235. Patel, K.D.; d’Andrea, F.B; Gaudelli, N.M.; Buller, A.R.; Townsend, C.A.; Gulick, A.M.; Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions. Nature Comm. 2019. Aug 27. 10:3868.

234. d’Andrea F.B.; Townsend C.A.; Late-Stage Conversion of Diphenylphosphonate to Fluorophosphonate Probes for the Investigation of Serine Hydrolases. Cell Chem Biol. 2019 Mar 20. pii: S2451-9456(19)30075-3.

233. Storm PA, Pal P, Huitt-Roehl CR, Townsend CA.; “Exploring fungal polyketide C-methylation through combinatorial domain swaps.” ACS Chem. Biol., 2018, 13 (11), 3043–3048

232. Ronnie de Jonge, Malaika K. Ebert, Callie R. Huitt-Roehl, Paramita Pal, Jeffrey C. Suttle, Rebecca E. Spanner, Jonathan D. Neubauer, Wayne M. Jurick, Karina A. Stott, Gary A. Secor, Bart P. H. J. Thomma, Yves Van de Peer, Craig A. Townsend, Melvin D. Bolton.; “Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to the genus Colletotrichum.”  PNAS. 2018, 115 (24), E5459-E5466.

231. Long, D.H.; Townsend, C.A.; “Mechanism of integrated β-lactam formation by a nonribosomal peptide synthetase during antibiotic synthesis.” Biochemistry. 2018, 57 (24), 3353-3358.

230. Saraiva, R.G.; Huitt-Roehl, C.R.; Tripathi, A.; Cheng Y.Q.; Bosch, J.; Townsend, C.A.; Dimopoulos, G.; “Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin.” Sci. Rep. 2018, 8 Article: 6176.

229. Herbst, D.A.; Huitt-Roehl, C.R.; Jakob, R.P.; Kravetz, J.M.; Storm, P.A.; Townsend, C.A.; Maier, T.; “The structural organization of substrate loading in iterative polyketide synthases.” Nat. Chem. Biol. 2018, 14(5), 474-479.

228. Cohen, D.R.; Townsend, C.A.; “Characterization of an anthracene intermediate in dynemicin biosynthesis.” Angew. Chem. Int. Ed. 2018, 57(20), 5650-5654.Designated VIP: Very Important Paper

227. Storm, P.A.; Townsend, C.A.; “In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.” Chem. Commun. 2018,54, 50-53.

226. Oliver, R.A.; Li, R.F.; Townsend, C.A.; “Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase.” Nat. Chem. Biol. 2018,14, 5-7.

225. Cohen, D.R.; Townsend, C.A.; “A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis.” Nat. Chem. 2018, 10, 231-236.

224. Horsman, M.E.; Marous, D.R.; Li, R.; Oliver, R.A.; Byun, B.; Emrich, S.J.; Boggess, B.; Townsend, C.A.; Mobashery S. “Whole-genome shotgun sequencing of two β-proteobacterial species in search of the bulgecin cluster.” ACS Chem. Biol. 2017, 12(10), 2552-2557.

223. Mattoo, R.; Lloyd, E.P.; Kaushik, A.; Kumar, P.; Brunelle, J.L.; Townsend, C.A.; Lamichhane, G. “Ldt_Mav2, a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems.” Future Microbiol. 2017

222. Bianchet, M.A.; Pan, Y.H.; Basta, L.A.B.; Saavedra, H.; Lloyd, E.P.; Kumar, P.; Mattoo, R.; Townsend, C.A.; Lamichhane, G. “Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt_Mt2 by biapenem and tebipenem.” BMC Biochem.2017, 18, 1-14.

221. Barajas, J.F.; Shakya, G.; Moreno, G.; Rivera, Jr., H.; Jackson, D.R.; Topper, C.L.; Vagstad, A.L.; La Clair, J.J.; Townsend, C.A.; Burkart, M.D.; Tsai, S.C. “Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.” Proc. Natl. Acad. Sci. U.S.A. 2017, 114, E4142-E4148.

220. Storm, P.A.; Herbst, D.A.; Maier, T.; Townsend, C.A. “Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin.” Cell Chemical Biology 2017, 24, 316-325.

219. Li, R.; Oliver, R.A.; Townsend, C.A. “Identification and Characterization of the Sulfazecin Monobactam Biosynthetic Gene Cluster.” Cell Chemical Biology 2016, 24, 24-34.

218. Kumar, P.; Kaushik, A.; Lloyd, E.P.; Li, S-G.; Mattoo, R.; Ammerman, N.C.; Bell, D.T.; Perryman, A.L.; Zandi, T.A.; Ekin, S.; Ginell, S.L.; Townsend, C.A.; Freundlich, J.S.; Lamichhane, G. “Non-classical transpeptidases yield insight into new antibacterials.” Nat. Chem. Biol.2016, 13, 54-61.

217. Townsend, C. A. “Convergent biosynthetic pathways to β-lactam antibiotics.” Curr. Opin. Chem. Biol. 2016, 35, 97-108.

216. Barajas, J.F.; Finzel, K.; Valentic, T.R.; Shakya, G.; Gamarra, N.; Martinez, D.; Meier, J.L.; Vagstad, A.L.; Newman, A.G.; Townsend, C.A.; Burkart, M.D.; Tsai, S-C. “Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl Carrier Protein and Product Template Domain.” Angew. Chem. Int. Ed. 2016, 55, 13005-13009.

215. Zhou, J.; Outlaw, V.K.; Townsend, C. A.; Bragg, A.E. “Quenching of pH-Responsive Luminescence in a Benzoindolizine Sensor by Ultrafast Hydrogen Shift.” Chemistry 2016, 22, 15212-15215.

214. Outlaw, V.K.; Zhou, J.; Bragg, A.E.; Townsend, C. A.; Bragg, A.E. “Unusual blue-shifted acid-responsive photoluminescence behavior in 6-amino-8-cyanobenzo[1,2-b]indolizines.” RSC Adv. 2016, 6, 61249.

213. Newman, A.G.; Townsend, C. A. “Molecular Characterization of the Cercosporin Biosynthetic Pathway in the Fungal Plant Pathogen Cercospora nicotianae.” J. Am. Chem. Soc. 2016, 138(12), 4219-4228.