212. Brammer Basta, L.A.; Ghosh, A.; Pan, Y.; Jakoncic, J.; Lloyd, E.P.; Townsend, C.A.; Lamichhane, G.; Bianchet, M. A. “Loss of a Functional and Structurally Distinct LD-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis.” J. Biol. Chem. 2015,290(42), 25670-25685.
211. Conradt, D.; Schätzle, M.A.; Haas, J.; Townsend, C. A.; Müller, M. “New insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1.” J. Am. Chem. Soc. 2015, 137(34), 10867-10869.
210. Marous, D.R.; Lloyd, E.P.; Buller, A.R.; Moshos, K.A.; Grove, T.L.; Blaszczyk, A.J.; Booker, S.J.; Townsend, C. A. “Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis.” Proc. Natl. Acad. Sci. U.S.A. 2015, 112(33), 10354-10358.
209. Outlaw, V.K.; d’Andrea, F.B.; Townsend, C. A. “One-Pot Synthesis of Highly Substituted N-Fused Heteroaromatic Bicycles from Azole Aldehydes.” Org. Lett. 2015, 17(8), 1822-1825.
208. Huitt-Roehl, C.R.; Hill, E.A.; Adams, M.M.; Vagstad, A.L.; Li, J.W.; Townsend, C. A. “Starter Unit Flexibility for Engineered Product Synthesis by the Nonreducing Polyketide Synthase PksA.” ACS Chem. Biol. 2015, 10, 1443-1449.
207. Gaudelli, N.M.; Long, D.H.; Townsend, C. A. “β-lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.” Nature2015, 520, 383-387.
206. Outlaw, V.K.; Townsend, C. A. “A Practical Route to Substituted 7-Aminoindoles from Pyrrole-3-carboxaldehydes” Org. Lett. 2014, 16, 6334-6337.
205. Buller, A.R.; Freeman, M.F.; Schildbach, J.F; Townsend, C. A. “Exploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT” Biochemistry 2014, 53(26), 4273-4281.
204. Outlaw, V.K.; Wydysh, E.A.; Vadlamundi, A.; Medghalchi, S.M.; Townsend, C. A. “Design, Synthesis, and Evaluation of 4- and 5-Substituted o-(Octanesulfonamido)benzoic Acids as Inhibitors of Glycerol-3-Phosphate Acyltransferase” Med. Chem. Commun. 2014, 5, 826-830.
203. Newman, A.G.; Vagstad, A.L.; Storm, P.A.; Townsend, C. A. “Systematic Domain Swaps of Iterative, Non-reducing Polyketide Synthases Provide a Mechanistic Understanding and Rationale For Catalytic Reprogramming” J. Am. Chem. Soc. 2014, 136, 7348-7362.
202. Gaudelli, N.M.; Townsend, C. A. “Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis” Nat. Chem. Biol. 2014,10, 251-258.
201. Li, R; Lloyd, E.P.; Moshos, K.A.; Townsend, C. A. “Identification and Characterization of the Carbapenem MM 4550 and its Gene Cluster in Streptomyces argenteolus ATCC 11009” Chembiochem 2014, 15(2), 320-331.
200. Townsend, C. A. “Enzymology: Modular biosynthesis branches out” Nature 2013, 502(7469), 44-45.
199. Belecki, K.; Townsend, C. A. “Biochemical Determination of Enzyme-Bound Metabolites: Preferential Accumulation of a Programmed Octaketide on the Enediyne Polyketide Synthase CalE8” J. Am. Chem. Soc. 2013, 135(38), 14339-14348.
198. Gaudelli, N.M.; Townsend, C. A. “Stereocontrolled Synthesis of Peptide Thioesters Containing Modified Seryl Residues as Probes of Antibiotic Biosynthesis” J. Org. Chem. Soc. 2013, 78(13), 6412-6426. Selected as Featured Article
197. Phelan, R.M.; Townsend, C. A. “Mechanistic Insights into the Bifunctional Non-Heme Iron Oxygenase Carbapenem Synthase by Active Site Saturation Mutagenesis” J. Am. Chem. Soc. 2013, 135(20), 7496-7502.
196. Buller, A.R.; Townsend, C. A. “Intrinsic Evolutionary Constraints on Protease Structure, Enzyme Acylation, and the Identity of the Catalytic Triad,” Proc. Natl. Acad. Sci. 2013, 110(8), E653-661.
195. Davidsen, J.M.; Bartley, D.M.; Townsend, C. A. “Nonribosomal Propeptide Precursor in Nocardicin A Biosynthesis Predicted from Adenylation Domain Specificity Dependent on MbtH Family Protein NocI,” J. Am. Chem. Soc. 2013, 135, 1749-1759.
194. Vagstad, A.L.; Newman, A.G.; Storm, P.A.; Belecki, K.; Crawford, J.M.; Townsend, C. A. “Combinatorial Domain Swaps Provide Insights into the Rules of Fungal Polyketide Synthase Programming and the Rational Synthesis of Non-native Aromatic Products,” Angew. Chem. Int. Ed.2013, 52, 1718-1721. Designated VIP: Very Important Paper
193. Labonte, J.W.; Townsend, C. A. “Active Site Comparisons and Catalytic Mechanisms of the Hot Dog Superfamily,” Chem. Rev. 2013, 113(3), 2182-2204.
192. Vagstad, A.L.; Hill, E.A.; Labonte, J.W.; Townsend, C. A. “Characterization of a Fungal Thioesterase Having Claisen Cyclase and Deacetylase Activities in Melanin Biosynthesis,” Chem. & Biol. 2012, 19, 1525-1534.
191. Newman, A.G.; Vagstad, A.L.; Belecki, K.B.; Scheerer, J.R.; Townsend, C.A. “Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function,” Chem. Commun. 2012, 48, 11772-11774
190. Belecki, K.; Townsend, C.A. “Environmental Control of the Calicheamicin Polyketide Synthase Leads to Detection of a Programmed Octaketide and a Proposal for Enediyne Biosynthesis,” Angew. Chem. Int. Ed. 2012, 51, 11316-11319.
189. Labonte, J.W.; Kudo, F.; Freeman, M.F.; Raber, M.L.; Townsend, C. A. “Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics,” MedChemComm 2012, 3, 960-966.
188. Foulke-Abel, J.; Townsend, C. A. “Demonstration of Starter Unit Interprotein Transfer from a Fatty Acid Synthase to a Multidomain, Nonreducing Polyketide Synthase,” ChemBioChem 2012, 13, 1880-1884.
187. Buller, A. R.; Labonte, J. W; Freeman, M. R.; Wright, N. T.; Schildbach J. F.; Townsend, C. A. “Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis,” J. Mol. Biol. 2012, 422, 508-518.
186. Phelan, R. M.; DiPardo, B. J.; Townsend, C. A. “A High-Throughput Screen for the Engineered Production of β-Lactam Antibiotics,” ACS Chem. Biol. 2012, 7, 835-840.
185. Vagstad, A. L.; Bumpus, S. B.; Belecki, K.; Kelleher, N.L.; Townsend, C. A. “Interrogation of Global Active Site Occupancy of a Fungal Iterative Polyketide Synthase Reveals Strategies for Maintaining Biosynthetic Fidelity,” J. Am. Chem. Soc. 2012, 134, 6865-6877.
184. Jensen, K.; Niederkruger, H.; Zimmermann, K.; Vagstad, A. L.; Moldenhauer, J.; Brendel, N.; Frank, S.; Poplau, P.; Kohlhaas, C.; Townsend, C. A.; Oldiges, M.; Hertweck, C.; Piel, J. “Polyketide Proofreading by an Acyltransferase-like Enzyme,” Chem. & Biol. 2012, 19, 329-339.
183. Davidsen, J. M.; Townsend, C. A. “In Vivo Characterization of Nonribosomal Peptide Synthases NocA and NocB in the Biosynthesis of Nocardicin A,” Chem. & Biol. 2012, 19, 297-306.
182. Buller, A. R.; Freeman, M. R.; Wright, N. T.; Schildbach J. F.; Townsend, C. A. “Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement,” Proc. Natl. Acad. Sci. 2012, 109, 2308-2313.
181. Townsend, C. A. “A Diels-Alderase at Last,” ChemBioChem. 2011, 12, 2267-2269.
180. Bodner, M. J.; Li, R. F.; Phelan, R. M.; Freeman, M. F.; Moshos, K. A.; Lloyd, E. P.; Townsend, C. A. “Definition of the Common and Divergent Steps in Carbapenem β-Lactam Antibiotic Biosynthesis,” ChemBioChem. 2011, 12, 2159-2165.
179. Kuhajda, F. P.; Aja, S.; Tu, Y.; Han, W. F.; Medghalchi, S. M.; El Meskini, R.; Landree, L. E.; Peterson, J. M.; Daniels, K.; Wong, K.; Wydysh, E. A.; Townsend, C. A.; Ronnett, G. V. “Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity,” Am. J. Physiol-Reg. I. 2011, 301, 116-130.