178. Crawford, J. M.; Townsend, C. A. “New insights into the formation of fungal aromatic polyketides,” Nature Rev. Microbiol. 2010, 12, 879-889.
177. Wydysh, E. A.; Vadlamudi, A.; Medghalchi, S. M.; Townsend, C. A. “Design, synthesis, and biological evaluation of conformationally constrained glycerol 3-phosphate acyltransferase inhibitors,” Bioorg. Med. Chem. 2010, 18, 6470-6479.
176. Ehrlich, K. C.; Chang, P.-K.; Scharfenstein, L. L., Jr.; Cary, J. W.; Crawford, J. M.; Townsend, C. A. “Absence of the Aflatoxin Biosynthesis Gene, norA, Allows Accumulation of Deoxyaflatoxin B1 in Aspergillus flavus Cultures,” FEMS Microbiol. Lett. 2010, 305, 65-70.
175. Korman, T. P.; Crawford, J. M.; Labonte, J. W.; Newman, A. G.; Wong, J.; Townsend, C. A.; Tsai, S.-C. “Structure and Function of an Iterative Polyketide Synthase Thioesterase Domain Catalyzing Claisen Cyclization in Aflatoxin Biosynthesis,” Proc. Natl. Acad. Sci. 2010, 107, 6246-6251.
174. Bodner, M. J.; Phelan, R. M.; Freeman, M. F.; Li, R.; Townsend, C. A. “Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics,” J. Am. Chem. Soc. 2010, 132, 12-13.
173. Raber, M. L.; Castillo, A.; Greer, A.; Townsend, C. A. “A Conserved Lysine in β-Lactam Synthetase Assists Ring Cyclization: Implications for Clavam and Carbapenem Biosynthesis,” ChemBioChem 2009, 10, 2904-2912.
172. Bodner, M. J.; Phelan, R. M.; Townsend, C. A. “A Catalytic Asymmetric Route to Carbapenems,” Org. Lett. 2009, 11, 3606-3609.
171. Belecki, K.; Crawford, J. M.; Townsend, C. A. “Production of Octaketide Polyenes by the Calicheamicin Polyketide Synthase CalE8: Implications for the Biosynthesis of Enediyne Core Structures,” J. Am. Chem. Soc. 2009, 131, 12564-12566.
170. Crawford, J. M.; Korman, T. P.; Labonte, J. W.; Vagstad, A. L.; Hill, E. A.; Kamari-Bidkorpeh, O.; Tsai, S.-C.; Townsend, C. A. “Structural Basis for Biosynthetic Programming of Fungal Aromatic Polyketide Cyclization,” Nature 2009, 461, 1139-1143. [News and Views: Nature 2009, 461, 1068-1069; Research Highlight: Nature Rev. Microbiol. 2009, 7, 842.]
169. Sokha, T.; Heins, R. A.; Phelan, R. M.; Greisler, J. M.; Townsend, C. A.; Ostermeier, M. “An Externally Tunable Bacterial Band-Pass Filter,” Proc. Natl. Acad. Sci. 2009, 106, 10135-10140.
168. Raber, M. L.; Arnett, S. O.; Townsend, C. A. “A Conserved Tyrosyl-Glutamyl Catalytic Dyad in Evolutionarily Linked Enzymes: Carbapenam Synthetase and β-Lactam Synthetase,” Biochemistry 2009, 48, 4959-4971.
167. Wydysh, E. A.; Medghalchi, S. M.; Vadlamudi, A.; Townsend, C. A. “Design and Synthesis of Small Molecule Glycerol 3-Phosphate Acyltransferase Inhibitors,” J. Med. Chem. 2009, 52, 3317-3327.
166. Phelan, R. M.; Ostermeier, M.; Townsend, C. A. “Design and Synthesis of a β-Lactamase Activated 5-Fluorouracil Prodrug,” Bioorg. Med. Chem. Lett. 2009, 19, 1261-1263.
165. Raber, M. L.; Freeman, M. F.; Townsend, C. A. “Dissection of the Stepwise Mechanism to β-Lactam Formation and Elucidation of a Rate-determining Conformational Change in β-Lactam Synthetase,” J. Biol. Chem. 2009, 284, 207-217.
164. Davidsen, J. M.; Townsend, C. A. “Identification and Characterization of NocR as a Positive Transcriptional Regulator of the β-Lactam Nocardicin A in Nocardia uniformis,” J. Bacteriol. 2009, 191, 1066-1077.
163. Freeman, M. F.; Moshos, K. A.; Bodner, M. L.; Li, R.; Townsend, C. A. “Four Enzymes Define the Incorporation of Coenzyme A in Thienamycin Biosynthesis,” Proc. Natl. Acad. Sci. 2008, 105, 11128-11133. [Spotlight: ACS Chem. Biol. 2008, 9, 518-523.]
162. Crawford, J. M.; Thomas, P. M.; Scheerer, J. R.; Vagstad, A. L.; Kelleher, N. L.; Townsend, C. A. “Deconstruction of Iterative Multidomain Polyketide Synthase Function,” Science 2008, 320, 243-246. [Research Highlight: Nature Rev. Microbiol. 2008, 6, 414-415.]
161. Crawford, J. M.; Vagstad, A. L.; Ehrlich, K. C.; Udwary, D. W.; Townsend, C. A. “Acyl-Carrier Protein-Phosphopantetheinyltransferase Partnerships in Fungal Fatty Acid Synthases,” ChemBioChem 2008, 9, 1559-1563.
160. Aja, S.; Landree, L. E.; Kleman, A. M.; Medghalchi, S. M.; Vadlamudi, A.; McFadden, J. M.; Aplasca, A.; Hyun, J.; Plummer, E.; Daniels, K.; Kemm, M.; Townsend, C. A.; Thupari, J. N.; Kuhajda, F. P.; Moran, T. H.; Ronnett, G. V. “Pharmacological Stimulation of Brain Carnitine Palmitoyl-Transferase-1 Decreases Food Intake and Body Weight,” Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008, 294, R352-R361.
159. Crawford, J. M.; Vagstad, A. L.; Whitworth, K. P.; Ehrlich, K. C.; Townsend, C. A. “Synthetic Strategy of Nonreducing Iterative Polyketide Synthases and the Origin of the Classical ‘Starter Unit Effect’,” ChemBioChem 2008, 9, 1019-1023.
158. Crawford, J. M.; Vagstad, A. L.; Ehrlich, K. C.; Townsend, C. A. “Starter Unit Specificity Directs Genome Mining of Polyketide Synthase Pathways in Fungi,” Bioorg. Chem. 2008, 36, 16-22.
157. Merski, M.; Townsend, C. A. “Observation of an Acryloyl-Thiamin Diphosphate Adduct in the First Step of Clavulanic Acid Biosynthesis,” J. Am. Chem. Soc. 2007, 129, 15750-15751.
156. Arnett, S. O.; Gerratana, B.; Townsend, C. A. “Rate-Limiting Steps and Role of Active Site Lys443 in the Mechanism of Carbapenem Synthase,” Biochemistry 2007, 46, 9337-9345. [selected as a 2007 Hot Article]
155. Zhou, W.; Han, W. F.; Landree, L. E.; Thupari, J. N.; Pinn, M. L.; Bililign, T.; Kim E. K.; Vadlamudi, A.; Medghalchi, S. M.; El Meskini, R.; Ronnett, G. V.; Townsend, C. A.; Kuhajda, F. P. “Fatty Acid Synthase Inhibition Activates AMP-Activated Protein Kinase in SKOV3 Human Ovarian Cancer Cells,” Cancer Res. 2007, 67, 2964-2971.
154. Crawford, J. M.; Dancy, B. C. R.; Hill, E. A.; Udwary, D. W.; Towsend, C. A. “Identification of a Starter-Unit Acyl-Carrier Protein Transacylase Domain in an Iterative Type I Polyketide Synthase,” Proc. Natl. Acad. Sci. 2006, 103, 16728-16733.
153. Li, R.; Townsend, C. A. “Rational Strain Improvement for Enhanced Clavulanic Acid Production by Genetic Engineering of the Glycolytic Pathway in Streptomyces clavuligerus,” Metabol. Eng. 2006, 8, 240-252.
152. Hughes, M. A.; Townsend, C. A. “Quantitative Proteomic Analysis of Drug-Induced Changes in Mycobacteria,” J. Proteome Res. 2006, 5, 54-63.
151. Muller, U.; van Assema, F.; Gunsior, M.; Orf, S.; Kremer, S.; Schipper, D.; Wagemans, A.; Townsend, C; Sonke, T.; Bovenberg, R.; Wubbolts, M. “Metabolic Engineering of the E. coli l-Phenylalanine pathway for the production of d-Phenylglycine (d-Phg),” Metabol. Eng. 2006, 8, 196-208.