{"id":7,"date":"2013-09-10T12:21:41","date_gmt":"2013-09-10T12:21:41","guid":{"rendered":"https:\/\/sites.krieger.jhu.edu\/template-research\/?page_id=7"},"modified":"2025-12-12T14:46:10","modified_gmt":"2025-12-12T19:46:10","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

135. Andrew Thampoe, Yu-Ju Peng, Michael S. Yoo, Klaire R. Bradley, Vinayak S. Khodade, Steven E. Rokita, and John P. Toscano \u201cDevelopment of Azoreductase-Activated Precursors for Efficient Hydropersulfide Release via 1,6-Elimination\u201d ACS Chem. Biol.<\/em> 2025<\/strong>, 20<\/em>, 2768-2778. (doi.org\/10.1021\/acschembio.5c00699)<\/p>\n

134. \u00a0Ravina Moirangthem and Steven E. Rokita \u201cA Subtle Change in Linker Structure Can Greatly Affect Cross-linking Efficiency of a Quinone Methide Conjugate\u201d Chem. Eur. J.<\/em> 2025<\/strong>, 31<\/em>, e02288 (dx.doi.org\/10.1002\/chem.202502288)<\/p>\n

133. Bing Xu, Zuodong Sun and Steven E. Rokita \u201cA Split Gene Approach to Alleviate Severe Inhibition of Catalysis by Substrate” Biochemistry<\/em> 2025<\/strong>, 64<\/em>, 2867-2876. (doi.org\/10.1021\/acs.biochem.5c00219)<\/p>\n

132. Yu-Ju Peng, Bing Xu, and Steven E. Rokita \u201cBreaking the Myth of Enzymatic Azoreduction\u201d ACS Chem. Biol.<\/em> 2025<\/strong>, 20<\/em>, 229-237 (doi.org\/10.1021\/acschembio.4c00779)<\/p>\n

131. Daniel Lemen and Steven E. Rokita \u201cPolar Interactions Between Substrate and Flavin Control Iodotyrosine Deiodinase Function\u201d Biochemistry<\/em> 2024<\/strong>, 63<\/em>, 2380-2389 (doi.org\/10.1021\/acs.biochem.4c00357)<\/p>\n

130. Harrison C. Greenberg, Ananya Majumdar, Ekroop Kaur Cheema, Anton Kozyryev and Steven E. Rokita \u201c19<\/sup>F NMR Reveals the Dynamics of Substrate Binding and Lid Closure for Iodotyrosine Deiodinase as a Complement to Steady-State Kinetics and Crystallography\u201d
\nBiochemistry<\/em> 2024<\/strong>, 63<\/em>, 2225-2232. (https:\/\/doi.org\/10.1021\/acs.biochem.4c00243)<\/p>\n

129. Qi Su, Bing Xu, Xin Chen and Steven E. Rokita \u201cMisregulation of Bromotyrosine Compromises Fertility in Male Drosophila\u201d Proc. Natl. Acad. Sci. USA<\/em> 2024<\/strong>, 121<\/em>, e2322501121 (https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2322501121)<\/p>\n

128. Anton Kozyryev, Petrina A. Boucher, Carla M. Qui\u00f1ones-Jurgensen and Steven E. Rokita \u201cThe 2′-hydroxy group of flavin mononucleotide influences the catalytic function and promiscuity of the flavoprotein iodotyrosine dehalogenase” RSC Chemical Biology<\/em> 2023<\/strong>, 4<\/em>, 698\u2013705 (DOI: 10.1039\/D3CB00094J).<\/p>\n

127. Ravina Moirangthem,#<\/sup> Manusha N. Gamage,#<\/sup> and Steven E. Rokita “Dynamic Accumulation of Cyclobutane Pyrimidine Dimers and its Response to Changes in DNA Conformation” Nucleic Acid Research<\/em>.\u00a02023<\/strong>, 51, 11, 5341-5350 (10.1093\/nar\/gkad434) #<\/sup>co-first authors<\/p>\n

126. Anton Kozyryev, Daniel Lemen, Jessica Dunn, and Steven E. Rokita “Substrate Electronics Dominate the Rate of Reductive Dehalogenation Promoted by the Flavin-Dependent Iodotyrosine Deiodinase”\u00a0Biochemistry<\/em>.\u00a02023<\/strong>, 62, 7, 1298-1306 (10.1021\/acs.biochem.3c00041)<\/p>\n

125. Jonathan M. Musila and Steven E. Rokita “Sequence Conservation Does Not Always Signify a Functional Imperative as Observed in the Nitroreductase Superfamily”\u00a0Biochemistry<\/em>.\u00a02022<\/strong>, 61, 8, 703-711 (10.1021\/acs.biochem.2c00037)<\/p>\n

124. Zuodong Sun, Bing Xu, Shaun Spisak, Jennifer M. Cavran & Steven E. Rokita “Minimal Structure for Iodotyrosine Deiodinase Function is Defined by an Outlier Protein from the Thermophilic Bacterium Thermatoga neapolitana” J. Biol. Chem.\u00a02021<\/strong>, 297(6), 101385 (10.1016\/j.jbc2021.101385)<\/p>\n

123. Mark A. Hutchinson, Blessing D. Deeyaa, Shane R. Byrne, Sierra J. Williams & Steven E. Rokita \u201cDirecting Quinone Methide-Dependent Alkylation and Cross-Linking of Nucleic Acids With Quaternary Amines\u201d Bioconjugate Chem. 2020<\/strong>, 31, 1486-1496 (10.1021\/acs.bioconjchem.0c00166).<\/span><\/p>\n

122. Blessing D. Deeyaa and Steven E. Rokita \u201cMigratory Ability of Quinone Methide-Generating Acridine Conjugates in DNA\u201d Org. Biomol. Chem. 2020<\/strong>, 18, 1671 – 1678.<\/span><\/p>\n

121. Steven E. Rokita \u201cReductive Dehalogenases\u201d in Comprehensive Natural Products III: Chemistry and Biology (H.-w. Liu & T. Begley, eds.) Wiley, 2020<\/strong>, vol. 4, ch. 8, 157-186.<\/span><\/p>\n

120. Shane R. Byrne, Kun Yang and Steven E. Rokita \u201cEffect of Nucleosome Assembly on Alkylation by a Dynamic Electrophile\u201d Chem. Res. Toxicol. 2019<\/strong>, 32, 917-925. (10.1021\/acs.chemrestox.9b00057)<\/span><\/p>\n

119. Jimin Hu, Qi Su, Jamie Schlessman and Steven E. Rokita \u201cRedox Control of Iodotyrosine Deiodinase\u201d Protein Science 2019<\/strong>, 28, 68-78. (https:\/\/doi.org\/10.1002\/pro.3479)<\/span><\/p>\n

118. Zuodong Sun and Steven E. Rokita \u201cTowards a Halophenol Dehalogenase from Iodotyrosine Deiodinase via Computational Design\u201d ACS Catalysis 2018<\/strong>, 8, 11783\u201311793 (DOI: 10.1021\/acscatal.8b03587)<\/span><\/p>\n

117. Abhishek Phatarphekar, Qi Su, Suk Ho Eun, Xin Chen, and Steven E. Rokita \u201cThe Importance of a Halotyrosine Dehalogenase for Drosophila Fertility\u201d J. Biol. Chem. 2018<\/strong>, 293, 10314\u201310321. (DOI 10.1074\/jbc.RA118.003364)<\/p>\n

116. Zuodong Sun, Qi Su, Steven E Rokita* \u201cThe Distribution and Mechanism of Iodotyrosine
\nDeiodinase Defied Expectations\u201d Arch. Biochem. Biophys.<\/em> 2017<\/strong>, 632, 77-87.
\n(DOI: 10.1016\/j.abb.2017.07.019)<\/p>\n

115. Qi Su, Petrina A. Boucher, and Steven E. Rokita* \u201cConversion of a Dehalogenase to a
\nNitroreductase by Swapping its Flavin Cofactor with a 5-Deazaflavin Analog.\u201d Angew. Chem.<\/em>
\nInt. Ed.<\/em> 2017<\/em>, 56, 10862-10866 (DOI: 10.1002\/anie.201703628).<\/p>\n

114. Nattha Ingavat, Jennifer M. Kavran, Zuodong Sun, and Steven E. Rokita* \u201cActive Site Binding
\nis not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase\u201d Biochemistry<\/em> 2017<\/strong>, 56,
\n1130-1139. (DOI: 10.1021\/acs.biochem.6b01308)<\/p>\n

113.Abhishek Phatarphekar, and Steven E. Rokita* “Functional Analysis of Iodotyrosine Deiodinase
\nFrom Drosophila melanogaster” Protein Science<\/em> 2016<\/strong>, 25, 2187-2195.<\/p>\n

112.Shalini Saha* and Steven E. Rokita* \u201cAn activator of an Adenylation Domain Revealed by
\nActivity but not Sequence Homology\u201d ChemBioChem<\/em> 2016<\/strong>, 17, 1818-1823.<\/p>\n

111. Chengyun Huang, Yang Liu and Steven E. Rokita* \u201cTargeting Duplex DNA with the Reversible
\nReactivity of Quinone Methides\u201d Signal Transduct Target Ther.<\/em> 2016<\/strong>, 1, 16009.
\n(doi:10.1038\/sigtrans.2016.9, http:\/\/www.nature.com\/articles\/sigtrans20169)<\/p>\n

110. Chengyun Huang and Steven E. Rokita* \u201cPromoting the Rate of DNA Alkylation with an
\nElectron Rich Quinone Methide Intermediate\u201d Front. Chem. Sci. Eng<\/em>. 2016<\/strong>, 10, 213-221.<\/p>\n

109. Arnab Mukherjee and Steven E. Rokita \u201cA Single Amino Acid Switch Between a FlavinDependent
\nDehalogenase and Nitroreductase\u201d J. Am. Chem. Soc.<\/em> 2015<\/strong>, 137, 15342\u201315345.
\n[PMCID# PMC4684082]<\/p>\n

108. Tuomas L\u00f6nnberg,* Mark A. Hutchinson and Steven E. Rokita \u201cSelective Alkylation of C-Rich
\nBulge Motifs in Nucleic Acids by Quinone Methide Derivatives\u201d Chem. Eur. J<\/em>. 2015<\/strong>, 21,
\n13127-13186. (http:\/\/dx.doi.org\/10.1002\/chem.201502014)<\/p>\n

107. Kostyantyn D. Bobyk, David P. Ballou and Steven E. Rokita* \u201cRapid Kinetics of Dehalogenation
\nPromoted by Iodotyrosine Deiodinase from Human Thyroid\u201d Biochemistry<\/em> 2015<\/strong>, 54, 4487\u20134494.
\n(http:\/\/dx.doi.org\/10.1021\/acs.biochem.5b00410). [PMCID# PMC4938124]<\/p>\n

106. Shalini Saha*, Wei Li, Barbara Gerratana, and Steven E. Rokita* \u201cIdentification of the
\nDioxygenase-Generated Intermediate Formed During Biosynthesis of the Dihydropyrrole
\nMoiety Common to Anthramycin and Sibiromycin\u201d Bioorg. Med. Chem<\/em>. 2015<\/strong>, 23, 449-454
\n(doi:10.1016\/j.bmc.2014.12.024).<\/p>\n

105. Jimin Hu, Watchalee Chuenchor, and Steven E. Rokita* \u201cA Switch Between One- and TwoElectron
\nChemistry of the Human Flavoprotein Iodotyrosine Deiodinase is Controlled by
\nSubstrate\u201d J. Biol. Chem<\/em>. 2015<\/strong>, 290, 590-600 (doi:10.1074\/jbc.M114.605964).<\/p>\n

104. Fazel Fakhari and Steven E. Rokita* \u201cA Walk Along DNA Using Bipedal Migration of a
\nDynamic and Covalent Cross-linker\u201d Nature Commun.<\/em> 2014<\/strong>, 5 5591 (doi: 10.1038\/ncomms6591<\/p>\n

103. Michael P. McCrane, Mark A. Hutchinson, Omer Ad, and Steven E. Rokita* \u201cOxidative
\nQuenching of Quinone Methide Adducts Reveals Transient Products of Reversible Alkylation in
\nDuplex DNA\u201d Chem. Res. Toxicol.<\/em> 2014<\/strong>, 27, 1282\u20131293 (http:\/\/dx.doi.org\/10.1021\/tx500152d).<\/p>\n

102. Neil P. Campbell and Steven E. Rokita* \u201cElectron Transport in DNA Initiated by Diaminonaphthalene
\nDonors Alternatively Bound by Non-Covalent and Covalent Association\u201d Org.<\/em>
\nBiomol. Chem.<\/em> 2014<\/strong>, 12, 1143 – 1148 (http:\/\/xlink.rsc.org\/?doi=C3OB42433B).<\/p>\n

101. Abhishek Phatarphekar, Jennifer M. Buss, and Steven E. Rokita* “Iodotyrosine Deiodinase:
\nA Unique Flavoprotein Present in Organisms of Diverse Phyla\u201d Mol. BioSyst.<\/em> 2014<\/strong>,
\n10, 86-92. (http:\/\/xlink.rsc.org\/?doi=C3MB70398C) [Highlighted in Nat. Chem. Biol. 2014, 10, 2.]<\/p>\n

100. Steven E. Rokita \u201cSynthetic Thyroid Hormone\u201d in Iodine: Chemistry and Application<\/em> (T. Kaiho,
\ned.) Wiley<\/em>, 2014<\/strong>, Ch. 21. pp. 411-420.<\/p>\n

99. Fazel Fakhari, Yun-Yun K. Chen and Steven E. Rokita* \u201cEnhancing Excess Electron Transport
\nin DNA\u201d Chem. Commun.<\/em> 2013<\/strong>, 49, 7073-7075. (http:\/\/xlink.rsc.org\/?doi=C3CC43887B)<\/p>\n

98. Amethist S. Finch, William B. Davis and Steven E. Rokita* \u201cAccumulation of the Cyclobutane
\nThymine Dimer in Defined Sequences of Free and Nucleosomal DNA\u201d Photochem. Photobiol.<\/em>
\nSci<\/em>. 2013<\/strong>, 12, 1474\u20131482. (http:\/\/xlink.rsc.org\/?doi=C3PP50147G)<\/p>\n

97. Steven E. Rokita \u201cFlavoprotein Dehalogenases\u201d in Handbook of Flavoproteins, vol. 1<\/em> (R. Hille,
\nS. M. Miller, B. Palfey eds.) DeGruyter, Berlin, 2013<\/strong>. p. 337-350.<\/p>\n

96. Jennifer M. Buss, Patrick M. McTamney and Steven E. Rokita* \u201cExpression of a Soluble Form of
\nIodotyrosine Deiodinase for Active Site Characterization by Engineering the Native Membrane
\nProtein from Mus musculus\u201d Protein Science<\/em> 2012<\/strong>, 21, 351-361.<\/p>\n

95. Yang Liu and Steven E. Rokita* \u201cInducible Alkylation of DNA by a Quinone Methide-Peptide
\nNucleic Acid Conjugate\u201d Biochemistry<\/em> 2012<\/strong>, 51, 1020-1027. [http:\/\/dx.doi.org\/10.1021\/bi201492b]<\/p>\n

94. Michael P. McCrane, Emily E. Weinert, Ying Lin, Eugene P. Mazzola, Yiu-Fai Lam, Peter F.
\nScholl, and Steven E. Rokita* \u201cTrapping a Labile Adduct Formed between an ortho-Quinone
\nMethide and 2′-Deoxycytidine\u201d Org. Lett.<\/em> 2011<\/strong>, 13, 1186\u20131189. (DOI: 10.1021\/ol200071p).<\/p>\n

93. Abulfazl Fakhari M. and Steven E. Rokita* \u201cA New Solvatochromic Fluorophore With High
\nSensitivity for Studying Biopolymers\u201d Chem. Commun.\u00a0<\/em>2011<\/strong>, 47, 4222 – 4224. (DOI:
\n10.1039\/c0cc04917d)<\/p>\n

92. Seung Jae Lee, Jamie L. Michalek, Angelique N. Besold, Steven E. Rokita, Sarah L. J. Michel*
\n\u201cClassical Cys2His2 Zinc Finger Peptides are Rapidly Oxidized by either H2O2 or O2 Irrespective
\nof Metal Coordination\u201d Inorg. Chem<\/em>. 2011<\/strong>, 50, 5442\u20135450. (DOI: 10.1021\/ic102252a).<\/p>\n

91. Clifford S. Rossiter, Emilia Modica, Dalip Kumar, and Steven E. Rokita* \u201cFew Constraints Limit
\nthe Design of Quinone Methide-Oligonucleotide Self-Adducts for Directing DNA Alkylation\u201d,
\nChem. Commun.<\/em> 2011<\/strong>, 47, 1476-1478. (DOI:10.1039\/C0CC03317K).<\/p>\n

90. Huan Wang and Steven E. Rokita* \u201cDynamic Cross-linking is Retained in Duplex DNA After
\nMultiple Exchange of Strands\u201d Angew. Chem. Int. Ed<\/em>. 2010<\/strong>, 49, 5957-5960.
\n[http:\/\/dx.doi.org\/10.1002\/anie.201001597]<\/p>\n

89. Steven E. Rokita,* Jennifer M. Adler, Patrick M. McTamney and James A. Watson, Jr \u201cEfficient
\nUse and Recycling of the Micronutrient Iodide in Mammals\u201d Biochimie<\/em> 2010<\/strong>, 92, 1227-1235.
\n[http:\/\/dx.doi.org\/10.1016\/j.biochi.2010.02.013, PMID: 20167242]<\/p>\n

88. Neil P. Campbell, Amethist S. Finch and Steven E. Rokita* \u201cModulating the Ground and Excited
\nState Oxidation Potentials of Diaminonapthalene by Sequential N-Methylation\u201d ChemPhysChem<\/em>
\n2010<\/strong>, 11, 1768 \u2013 1773. (http:\/\/dx.doi.org\/10.1002\/cphc.200900969, PMID: 20376874).<\/p>\n

87. Patrick M. McTamney, and Steven E. Rokita* \u201cA Mammalian Reductive Deiodinase has Broad
\nPower to Dehalogenate Chlorinated and Brominated Substrates\u201d J. Am. Chem. Soc.<\/em> 2009<\/strong>, 131,
\n14212\u201314213. (doi: 10.1021\/ja906642n, PMID: 19777994) (PMCID: PMC2758933)<\/p>\n

86. Seth R. Thomas, Patrick M. McTamney, Jennifer M. Adler, Nicole LaRonde-LeBlanc* and
\nSteven E. Rokita* \u201cCrystal Structure of Iodotyrosine Deiodinase, A Novel Flavoprotein
\nResponsible for Iodide Salvage in Thyroid Glands\u201d J. Biol. Chem.<\/em> 2009<\/strong>, 284, 19659-19667.
\n(doi: 10.1074\/jbc.M109.013458; PMCID: PMC2740591<\/p>\n

85. Steven E. Rokita \u201cReversible Alkylation of DNA by Quinone Methides\u201d in volume 1, Quinone<\/em>
\nMethides in Chemistry and Biology of the Wiley Series on Reactive Intermediates in Chemistry<\/em>
\nand Biology<\/em> (Rokita, S.E., Ed.) Wiley, New York, 2009<\/strong>, p.297-327.<\/p>\n

84. Qing Zhu, Sunita Thyagarajan, Steven E. Rokita, Kenneth D. Karlin* and Neil V. Blough*
\n\u201cHydrogen Peroxide and Dioxygen Activation by Dinuclear Copper Complexes in Aqueous
\nSolution: Hydroxyl Radical Production Initiated by Internal Electron Transfer\u201d J. Am. Chem.<\/em>
\nSoc.<\/em> 2008<\/strong>, 130, 6304-6305.<\/p>\n

83. James A. Watson, Jr., Patrick M. McTamney, Jennifer M. Adler, and Steven E. Rokita* \u201cThe
\nFlavoprotein Iodotyrosine Deiodinase Functions without Cysteine Residues” ChemBioChem<\/em>
\n2008<\/strong>, 9, 504-506.<\/p>\n

82. Huan Wang, Manvinder S. Wahi and Steven E. Rokita* \u201cImmortalizing a Transient Electrophile
\nfor DNA Cross-linking\u201d Angew. Chem. Int. Ed.<\/em> 2008<\/strong>, 47, 1291-1293. [10.1002\/anie.200704137]<\/p>\n

81. Matthew R. Holman, Takeo Ito, Steven E. Rokita* \u201cSelf-repair of Thymine Dimer in Duplex
\nDNA\u201d J. Am. Chem. Soc<\/em>. 2007<\/strong>, 129, 6-7.<\/p>\n

80. Emily E. Weinert, Ruggero Dondi, Stefano Colloredo-Melz, Kristen N. Frankenfield, Charles H.
\nMitchell, Mauro Freccero* and Steven E. Rokita* \u201cSubstituents on Quinone Methides Strongly
\nModulate Formation and Stability of Their Nucleophilic Adducts\u201d J. Am. Chem. Soc.<\/em> 2006<\/strong>, 128,
\n11940-11947. [http:\/\/dx.doi.org\/10.1021\/ja062948k]<\/p>\n

79. Lei Li, Narasimha N. Murthy, Joshua Telser, Lev. N. Zakharov, Glenn P. A. Yap, Arnold L.
\nRheingold, Kenneth D. Karlin* and Steven E. Rokita* \u201cTargeted Guanine Oxidation by a
\nDinuclear Copper(II) Complex a Single Stranded\/Double Stranded DNA Junctions\u201d Inorg.<\/em>
\nChem<\/em>. 2006<\/strong>, 45, 7144-7159.<\/p>\n

78. Sunita Thyagarajan, N. N. Murthy, Amy Sargeant, Kenneth D. Karlin* and Steven E. Rokita*
\n\u201cSelective DNA Strand Scission with Binuclear Copper Complexes: Implications for the
\nInvolvement of a Cu2-O2 Active Species\u201d J. Am. Chem. Soc.<\/em> 2006<\/strong>, 128, 7003-7008.<\/p>\n

77. Jessica E. Friedman, James A.Watson Jr., David W.-H. Lam and Steven E. Rokita*
\n\u201cIodotyrosine Deiodinase is the First Mammalian Member of the NADH Oxidase\/Flavin
\nReductase Superfamily\u201d J. Biol. Chem<\/em>. 2006<\/strong>, 281, 2812-2819.<\/p>\n

76. Takeo Ito, Sunita Thyagarajan, Kenneth D. Karlin and Steven E. Rokita* \u201cRecognition of
\nGuanines at a Double Helix-Coil Junction in DNA by a Trinuclear Copper Complex\u201d Chem.<\/em>
\nCommun.<\/em> 2005<\/strong>, 4812-4814.<\/p>\n

75. Emily E. Weinert, Kristen N. Frankenfield and Steven E. Rokita* \u201cTime-dependent Evolution of
\nAdducts Formed Between Deoxynucleosides and a Model Quinone Methide\u201dChem. Res.<\/em>
\nToxicol<\/em>. 2005<\/strong>, 18, 1364-1370. [http:\/\/dx.doi.org\/10.1021\/tx0501583]<\/p>\n

74. Lei Li, Kenneth D. Karlin* and Steven E. Rokita* \u201cChanging Selectivity of DNA Oxidation
\nfrom Deoxyribose to Guanine by Ligand Design and a New Binuclear Copper Complex\u201d J. Am.<\/em>
\nChem. Soc.<\/em> 2005<\/strong>, 127, 520-521.<\/p>\n

73. Steven E. Rokita and Takeo Ito \u201cChemical Probing of Reductive Electron Transfer in DNA\u201d in
\nCharge Transfer in DNA<\/em> (Wagenknecht, H.-A., Ed), Wiley-VCH, Weinheim, 2005<\/strong>, Ch. 6, 133-151.<\/p>\n

72. Takeo Ito and Steven E. Rokita* \u201cReductive Electron Injection into Duplex DNA by Aromatic
\nAmines\u201d J. Am. Chem. Soc<\/em>. 2004<\/strong>, 126, 15552-15559.<\/p>\n

71. Dalip Kumar, Willem F. Veldhuyzen, Qibing Zhou and Steven E. Rokita* \u201cConjugation of a
\nHairpin Pyrrole-Imidazole Polyamide to a Quinone Methide for Control of DNA Cross-linking\u201d
\nBioconj. Chem<\/em>. 2004<\/strong>, 15, 915-922.<\/p>\n

70. Dalip Kumar and Steven E. Rokita* \u201cSynthesis of a Hairpin Pyrrole-Imidazole Polyamide
\nConjugate Containing a Quinone Methide Precursor and Vinyl Linking Group\u201c Tet. Lett.<\/em> 2004<\/strong>,
\n45, 2887-2889.<\/p>\n

69. Takeo Ito and Steven E. Rokita* \u201cCriteria for Efficient Transport of Excess Electrons in DNA\u201d
\nAngew. Chem. Int. Ed<\/em>. 2004<\/strong>, 43, 1839-1842.<\/p>\n

68. Willem F. Veldhuyzen, Praveen Pande and Steven E. Rokita* \u201cA Transient Product of DNA
\nAlkylation Can Be Stabilized by Binding Localization\u201d J. Am. Chem. Soc<\/em>. 2003<\/strong>, 125, 14005-
\n14013. [http:\/\/dx.doi.org\/10.1021\/ja036943o]<\/p>\n

67. Qibing Zhou and Steven E. Rokita* \u201cA General Strategy for Target-Promoted Alkylation in
\nBiological Systems\u201d Proc. Natl. Acad. Sci. (USA)<\/em> 2003<\/strong>, 100, 15452-15457.
\n[http:\/\/dx.doi.org\/10.1073\/pnas.2533112100]<\/p>\n

66. Takeo Ito and Steven E. Rokita* \u201cExcess Electron Transfer from An Internally-Conjugated
\nAromatic Amine to 5-Bromo-2′-Deoxyuridine in DNA\u201d J. Am. Chem. Soc<\/em>. 2003<\/strong>, 125, 11480-11481.<\/p>\n

65. William H. Walker IV and Steven E. Rokita* \u201cUse of a Boroxazolidone Complex of 3-Iodo-LTyrosine
\nfor Palladium-Catalyzed Cross-Coupling\u201d J. Org. Chem<\/em>. 2003<\/strong>, 68, 1563-1566.<\/p>\n

64. Steven E. Rokita and Cynthia J. Burrows \u201cSalen Metal Complexes\u201d in Small Molecule DNA and<\/em>
\nRNA Binders; From Synthesis to Nucleic Acid Complexes<\/em> (Demeunynck, Bailly, Wilson, Eds),
\nWiley-VCH, Weinheim, 2003<\/strong>, ch. 6, pp. 126-145.<\/p>\n

63. Kristi J. Humphreys, Kenneth D. Karlin* and Steven E. Rokita* \u201cTargeted Strand Scission of DNA
\nSubstrates by a Tricopper(II) Coordination Complex\u201d J. Am. Chem. Soc.<\/em> 2002<\/strong>, 124, 8055-8066.<\/p>\n

62. Kristi J. Humphreys, Anne E. Johnson, Kenneth D. Karlin* and Steven E. Rokita* \u201cOxidative
\nStrand Scission of Nucleic Acids by a Multinuclear Copper(II) Complex\u201d J. Biol. Inorg. Chem<\/em>.
\n2002<\/strong>, 7, 835-842.<\/p>\n

61. Kristi J. Humphreys, Kenneth D. Karlin* and Steven E. Rokita* \u201cEfficient and Specific Strand
\nScission of DNA by a Binuclear Copper Complex: Comparative Reactivity of the Complexes
\nwith Linked Tris(2-pyridylmethyl)amine Moieties\u201d J. Am. Chem. Soc.<\/em> 2002<\/strong>, 124, 6009-6019.<\/p>\n

60. Willem F. Veldhuyzen, Anthony J. Shallop, Roger A. Jones and Steven E. Rokita*
\n\u201cThermodynamic versus Kinetic Products of DNA Alkylation as Modeled by Reaction of
\nDeoxyadenosine\u201d J. Am. Chem. Soc<\/em>. 2001<\/strong>, 123, 11126-11132.<\/p>\n

59. Qibing Zhou, Praveen Pande, Anne E. Johnson and Steven E. Rokita* \u201cSequence-Specific
\nDelivery of a Quinone Methide Intermediate to the Major Groove of DNA\u201d Bioorg. Med. Chem.<\/em>
\n2001<\/strong>, 9, 2347-2354.<\/p>\n

58. Kristi J. Humphreys, Kenneth D. Karlin* and Steven E. Rokita* \u201cRecognition and Strand
\nScission at Junctions between Single- and Double-Stranded DNA by a Trinuclear Copper
\nComplex\u201d J. Am. Chem. Soc<\/em>. 2001<\/strong>, 123, 5588-5589.<\/p>\n

57. Willem F. Veldhuyzen, Yui-Fai Lam and Steven E. Rokita* \u201c2-Deoxyguaninosine Reacts with
\na Model Quinone Methide at Multiple Sites\u201d Chem. Res. Toxicol<\/em>. 2001<\/strong>, 14, 1345-1351.<\/p>\n

56. Steven E. Rokita* \u201cChemical Reagents for Investigating the Major Groove of DNA\u201d in Current<\/em>
\nProtocols in Nucleic Acid Chemistry<\/em> (G. Glick, Ed.) Wiley, New York, 2001<\/strong>, 6.6.1-6.6.16.<\/p>\n

55. Steven E. Rokita* and Cynthia J. Burrows \u201cNickel- and Cobalt-Dependent Oxidation and
\nCross-Linking of Proteins\u201d in Metal Ions in Biological Systems<\/em> vol. 38 (H. Sigel, ed.) Marcel
\nDekker, New York, 2001<\/strong>, ch. 10, 289-311.<\/p>\n

54. Xiang Zhou, Jason M. Shearer, and Steven E. Rokita* \u201cA Ni(Salen)-Biotin Conjugate for
\nRapid Isolation of Accessible DNA\u201d J. Am. Chem. Soc.<\/em> 2000<\/strong>, 122, 9046-9047.<\/p>\n

53. Steven E. Rokita* and Cynthia J. Burrows “Structural Studies of Nucleic Acids Using Nickel
\nand Cobalt Based Reagents” in Current Protocols in Nucleic Acid Chemistry<\/em> (G. Glick, Ed.)
\nWiley, New York, 2000<\/strong>, 6.4.1-6.4.7.<\/p>\n

52. Hui-Chen Shih, Helina Kassahun, Cynthia J. Burrows and Steven E. Rokita* “Selective
\nAssociation between a Macrocyclic Nickel Complex and Extrahelical Guanine Residue”
\nBiochemistry<\/em> 1999<\/strong>, 38, 15034-15042.<\/p>\n

51. Ning Tang, James G. Muller, Cynthia J. Burrows and Steven E. Rokita* “Nickel and Cobalt
\nReagents Promote Selective Oxidation of Z-DNA” Biochemistry<\/em> 1999<\/strong>, 38, 16648-16654.<\/p>\n

50. Praveen Pande, Jason M. Shearer, Jianhong Yang, William A. Greenberg and Steven E.
\nRokita*Alkylation of Nucleic Acids by a Model Quinone Methide” J. Am. Chem. Soc.<\/em> 1999<\/strong>,
\n121, 6773 -6779.<\/p>\n

49. Munetaka Kunishima, Jessica E. Friedman and Steven E. Rokita* “Transition-State Stabilization
\nby a Mammalian Reductive Dehalogenase” J. Am. Chem. Soc<\/em>. 1999<\/strong>, 121, 4722-4723.<\/p>\n

48. James Muller, Lou Anne Kayser, Sari Paikoff, Victor Duarte, Ning Tang, Ronelito Perez,
\nSteven E. Rokita and Cynthia J. Burrows* “Formation of DNA Adducts Using Nickel(II)
\nComplexes of Redox-Active Ligands: A comparison of salen and peptide complexes” Coord.<\/em>
\nChem. Rev.<\/em> 1999<\/strong>, 186, 761-774.<\/p>\n

47. Jason M. Shearer and Steven E. Rokita* “Diamine Preparation for Synthesis of a Water
\nSoluble Ni(II) Salen Complex” Bioorg. Med. Chem. Lett<\/em>. 1999<\/strong>, 9, 510-504.<\/p>\n

46. Robyn Hickerson, Victor Duarte, J. David Van Horn, Ronelito Perez, James Muller, Steven E.
\nRokita, and Cynthia J. Burrows* “DNA Cleavage vs. Cross-linking using Nickel Peptides:
\nMechanistic Aspects” in Metals and Genetics<\/em> (B. Sarkar, Ed.), Plenum: New York, 1999<\/strong>,
\n183-196.<\/p>\n

45. Hui-Chen Shih, Ning Tang, Cynthia J. Burrows and Steven E. Rokita* “Nickel-based Probes of
\nNucleic Acid Structure Bind to Guanine but do not Perturb a Dynamic Equilibrium of
\nExtrahelical Guanine Residues” J. Am. Chem. Soc<\/em>. 1998<\/strong>, 120, 3284-3288.<\/p>\n

44. Ping Zheng, Cynthia J. Burrows and Steven E. Rokita* “Nickel- and Cobalt-Dependent
\nReagents Identify Structural Features of RNA that are not Detected by Dimethyl Sulfate or
\nRNase T1” Biochemistry<\/em> 1998<\/strong>, 37, 2207-2214.<\/p>\n

43. Cynthia J. Burrows,* Ronelito J. Perez, James G. Muller and Steven E. Rokita “Oxidative DNA
\nDamage Mediated by Metal-Peptide Complexes” Pure and Applied Chem<\/em>. 1998<\/strong>, 70, 275-278.<\/p>\n

42. Nicholas Delihas,* Steven E. Rokita, and Ping Zheng “Natural Antisense RNA\/target RNA
\ninteractions–possible models for antisense oligonucleotide drug design” Nature Biotechnology<\/em>
\n1997<\/strong>, 15, 751-753.<\/p>\n

41. Steven E. Rokita*, Jianhong Yang, Praveen Pande, William A. Greenberg “Quinone Methide
\nAlkylation of Deoxycytidine” J. Org. Chem<\/em>. 1997<\/strong>, 62, 3010-3012.<\/p>\n

40. Gurpreet Gill, Angelika Richter-Rusli, Madhushree Ghosh, Cynthia J. Burrows and Steven E.
\nRokita* “Nickel-Dependent Oxidative Cross-linking of a Protein” Chem. Res. Toxicol<\/em>. 1997<\/strong>, 10,
\n302-309.<\/p>\n

39. Qingping Zeng and Steven E. Rokita* “Tandem Quinone Methide Generation for Crosslinking
\nDNA” J. Org. Chem<\/em>. 1996<\/strong>, 61, 9080-9081.<\/p>\n

38. Hyunmin Kang and Steven E. Rokita* “Site-Specific and Photo-Induced Alkylation of DNA by a
\nDimethylanthraquinone-Oligodeoxynucleotide Conjugate” Nucleic Acids Res.<\/em> 1996<\/strong>, 24, 3896-3902.<\/p>\n

37. Grant A. McLachlan, James G. Muller, Steven E. Rokita and Cynthia J. Burrows* “MetalMediated
\nOxidation of Guanines in DNA and RNA: A Comparison of Cobalt(II), Nickel(II) and
\nCopper(II) Complexes” Inorg. Chim. Acta<\/em> 1996<\/strong>, 251, 193-199.<\/p>\n

36. Chien-Chung Cheng, Julia Gulia, Steven E. Rokita and Cynthia J. Burrows* “Dioxygen Chemistry
\nof Nickel(II) Dioxopentaazamacrocyclic Complexes: Substituent and Medium Effects” J. Mol.<\/em>
\nCatal<\/em>. 1996<\/strong>, 113, 379-391.<\/p>\n

35. James G. Muller, Ping Zheng, Steven E. Rokita and Cynthia J. Burrows* “DNA Modification
\nPromoted by [Co(H2O)6]Cl2: Probing Temperature-Dependent Conformations” J. Am. Chem. Soc.<\/em>
\n1996<\/strong>, 118, 2320-2325.<\/p>\n

34. Cynthia J. Burrows,* James G. Muller, Gregory T. Poulter, and Steven E. Rokita \u201cNickel-Catalyzed
\nOxidations: From Hydrocarbons to DNA” Acta Chem. Scand<\/em>. 1996<\/strong>, 50, 337-344.<\/p>\n

33. Cynthia J. Burrows* and Steven E. Rokita “Nickel Complexes as Probes of Guanine Sites in
\nNucleic Acid Folding” in Metal Ions in Biological Systems<\/em> (H. Sigel, ed.) Marcel Dekker, New
\nYork, 1996<\/strong>, Ch. 18, pp. 537-560.<\/p>\n

32. Cynthia J. Burrows,* James G. Muller, Hui-Chen Shih and Steven E. Rokita “Recognition
\nof B vs Z-Form DNA Using Nickel and Cobalt Complexes” in Supramolecular<\/em>
\nStereochemistry<\/em> (J. S. Siegel, ed.), Kluwer, Dordrecht, 1995<\/strong>, 57-62.<\/p>\n

31. Steven E. Rokita,* Ping Zheng, Ning Tang, Chien-Chung Cheng, Ren-Hwa Yeh, James G.
\nMuller, and Cynthia J. Burrows “Nickel Complexes in Modification of Nucleic Acids” in
\nGenetic Response to Metals<\/em> (B. Sarkar, Ed.), Marcel Dekker, New York, 1995<\/strong>, pp 201-216.<\/p>\n

30. Cynthia J. Burrows* and Steven E. Rokita* “Probing Guanine Structure in Nucleic Acid
\nFolding using Nickel Complexes” Acc. Chem. Res<\/em>. 1994<\/strong>, 27, 295-301.<\/p>\n

29. Tianhu Li, Qingping Zeng and Steven E. Rokita* “Target Promoted Alkylation of DNA”
\nBioconj. Chem<\/em>. 1994<\/strong>, 5, 497-500.<\/p>\n

28. James G. Muller, Sari J. Paikoff, Steven E. Rokita* and Cynthia J. Burrows* “DNA Modification
\nPromoted by Water-Soluble Nickel(II) Salen Complexes: A Switch to DNA Alkylation” J.<\/em>
\nInorg. Biochem<\/em>. 1994<\/strong>, 54, 199-206.<\/p>\n

27. Moneesh Chatterjee and Steven E. Rokita* “The Role of a Quinone Methide in the Sequence
\nSpecific Alkylation of DNA” J. Am. Chem. Soc.<\/em> 1994<\/strong>, 116, 1690-1697.<\/p>\n

26. Sarah A. Woodson,* James G. Muller, Cynthia J. Burrows and Steven E. Rokita “A Primer
\nExtension Assay for Modification of Guanine by Ni(II) Complexes” Nucleic Acids Res.<\/em> 1993<\/strong>,
\n21, 5524-5525.<\/p>\n

25. Ute H\u00e4nsler and Steven E. Rokita* “Electrostatics Rather Than Conformation Control the Oxidation
\nof DNA by the Anionic Reagent Permanganate” J. Am. Chem. Soc.<\/em> 1993<\/strong>, 115, 8554-8557.<\/p>\n

24. Xiaoying Chen, Sarah A. Woodson, Cynthia J. Burrows* and Steven E. Rokita* “A Highly
\nSensitive Probe for Guanine N7 in Folded Structures of RNA: Application to tRNAphe and
\nTetrahymena Group I Intron” Biochemistry<\/em> 1993<\/strong>, 32, 7610-7616.<\/p>\n

23. James G. Muller, Xiaoying Chen, Adonis C. Dadiz, Steven E. Rokita* and Cynthia J. Burrows*
\n“Macrocyclic Nickel Complexes in DNA Recognition and Oxidation” Pure and Applied Chem.<\/em>
\n1993<\/strong>, 65, 545-550.<\/p>\n

22. Chien-Chung Cheng, Steven E. Rokita* and Cynthia J. Burrows* “Nickel(III)-Promoted
\nDNA Scission Using Ambient Dioxygen” Angew. Chem. Int. Ed<\/em>. 1993<\/strong>, 32, 277-278.<\/p>\n

21. Steven E. Rokita* and Lorraine Romero-Fredes “The Ensemble Reactions of Hydroxyl
\nRadical Exhibit No Specificity for Primary or Secondary Structure of DNA” Nucleic Acids<\/em>
\nRes.<\/em> 1992<\/strong>, 20, 3069 – 3072.<\/p>\n

20. James G. Muller, Xiaoying Chen, Adonis C. Dadiz, Steven E. Rokita* and Cynthia J.
\nBurrows* “Ligand Effects Associated with the Intrinsic Selectivity of DNA Oxidation
\nPromoted by Nickel(II) Macrocyclic Complexes” J. Am. Chem. Soc.<\/em> 1992<\/strong>, 114, 6407 – 6411.<\/p>\n

19. Xiaoying Chen, Cynthia J. Burrows* and Steven E. Rokita* “Conformation Specific Detection
\nof Guanosine in DNA: Ends, Mismatches, Bulges and Loops” J. Am. Chem. Soc<\/em>. 1992<\/strong>, 114,
\n322 – 325.<\/p>\n

18. John E. Butler-Ranshoff, Steven E. Rokita, Debra A. Kendall, Jennifer A. Banzon, Kristin
\nS. Carano, Emil Thomas Kaiser and Albert R. Matlin* “Active-Site Mutagenesis of E. coli
\nAlkaline Phosphatase: Replacement of Serine-102 with Non-Nucleophilic Amino Acids”
\nJ. Org. Chem.<\/em> 1992<\/strong>, 57, 142 – 145.<\/p>\n

17. Tianhu Li and Steven E. Rokita* “Selective Modification of DNA Controlled by an Ionic
\nSignal” J. Am. Chem. Soc<\/em>. 1991<\/strong>, 113, 7771 – 7773.<\/p>\n

16. Xiaoying Chen, Steven E. Rokita* and Cynthia J. Burrows* “DNA Modification: Intrinsic
\nSelectivity of Nickel(II)-Complexes” J. Am. Chem. Soc<\/em>. 1991<\/strong>, 113, 5884 – 5886.<\/p>\n

15. Moneesh Chatterjee and Steven E. Rokita* “Sequence Specific Alkylation of DNA Activated by
\nan Enzymatic Signal” J. Am. Chem. Soc.<\/em> 1991<\/strong>, 113, 5116 – 5117.<\/p>\n

14. Elisa M. Woolridge and Steven E. Rokita* “The Use of 6-(Difluoromethyl)indole to Study the
\nActivation of Indole by Tryptophan Synthase” Arch. Biochem. Biophys<\/em>. 1991<\/strong>, 286, 473 – 480.<\/p>\n

13. Elisa M. Woolridge and Steven E. Rokita* “6-(Difluoromethyl)tryptophan as a Probe for
\nSubstrate Activation During the Catalysis of Tryptophanase” Biochemistry<\/em> 1991<\/strong>, 30, 1852-1857.<\/p>\n

12. Moneesh Chatterjee and Steven E. Rokita* “A Quinone Based Method for Inducible Alkylation
\nof DNA at Predetermined Sequences” J. Am. Chem. Soc<\/em>. 1990<\/strong>, 112, 6397 – 6399.<\/p>\n

11. Steven E. Rokita*, Stacey Prusiewicz and Lorraine Romero-Fredes “The Effect of Ionic Strength
\non the Photosensitized Oxidation of d(CG)6” J. Am. Chem. Soc.<\/em> 1990<\/strong>, 112, 3616 – 3621.<\/p>\n

10. Steven E. Rokita*, Bernard Lau and Lorraine Romero-Fredes “Structural Dependence of
\nOligonucleotide Photooxidation” Biopolymers<\/em> 1990<\/strong>, 29, 69 – 77.<\/p>\n

9. Steven E. Rokita* and Lorraine Romero-Fredes “Facile Interconversion of Duplex Structures
\nFormed by Copolymers of d(CG)” Biochemistry<\/em> 1989<\/strong>, 28, 9674 – 9679.<\/p>\n

8. Elisa M. Woolridge and Steven E. Rokita* “Synthesis and Reactivity of 6-(Fluoromethyl)indole
\nand 6-(Difluoromethyl)indole” Tet. Lett.<\/em> 1989<\/strong>, 30, 6117 – 6120.<\/p>\n

7. Xiaoyan Ma and Steven E. Rokita* “Role of Oxygen During Horseradish Peroxidase Turnover
\nand Inactivation” Biochem. Biophys. Res. Commun<\/em>. 1988<\/strong>, 157, 160 – 165.<\/p>\n

Publications prior to beginning independent career:<\/strong><\/p>\n

6. Steven E. Rokita and E. T. Kaiser* “Flavolysozyme, a New Semi-Synthetic Enzyme” J. Am. Chem.<\/em>
\nSoc.<\/em> 1986<\/strong>, 108, 4984 – 4987.<\/p>\n

5. Soumitra S. Ghosh, Susan C. Bock, Steven E. Rokita and E. T. Kaiser* “Modification of the Active
\nSite of Alkaline Phosphatase by Site-Directed Mutagenesis” Science<\/em> 1986<\/strong>, 231, 145 – 148.<\/p>\n

4. E. T. Kaiser*, David S. Lawrence and Steven E. Rokita “The Chemical Modification of
\nEnzymatic Specificity” Ann. Rev. in Biochemistry<\/em> 1985<\/strong>, 54, 565 – 595.<\/p>\n

3. Steven E. Rokita* and Christopher T. Walsh “Flavin and 5-Deazaflavin Photosensitized
\nCleavage of Thymine Dimer: A Model of in Vivo Light-Requiring DNA Repair” J.<\/em>
\nAm. Chem. Soc.<\/em> 1984<\/strong>, 106, 4589 – 4595.<\/p>\n

2. Steven E. Rokita and Christopher T. Walsh* “Turnover and Inactivation of Bacterial
\nCitrate Lyase with 2-Fluorocitrate and 2-Hydroxycitrate Stereoisomers” Biochemistry<\/em>
\n1983<\/strong>, 22, 2821 – 2828.<\/p>\n

1. Steven E. Rokita, Paul Srere and Christopher T. Walsh* “3-Fluoro-3-deoxycitrate: A Probe
\nfor the Mechanistic Study of Citrate Utilizing Enzymes” Biochemistry<\/em> 1982<\/strong>, 21, 3765 – 3774.<\/p>\n","protected":false},"excerpt":{"rendered":"

135. Andrew Thampoe, Yu-Ju Peng, Michael S. Yoo, Klaire R. Bradley, Vinayak S. Khodade, Steven E. Rokita, and John P. Toscano \u201cDevelopment of Azoreductase-Activated Precursors for Efficient Hydropersulfide Release via 1,6-Elimination\u201d ACS Chem. Biol. 2025, 20, 2768-2778. (doi.org\/10.1021\/acschembio.5c00699) 134. \u00a0Ravina Moirangthem and Steven E. Rokita \u201cA Subtle Change in Linker Structure Can Greatly Affect Cross-linking […]<\/p>\n","protected":false},"author":40,"featured_media":49,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-7","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/wp-json\/wp\/v2\/pages\/7","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/wp-json\/wp\/v2\/users\/40"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/wp-json\/wp\/v2\/comments?post=7"}],"version-history":[{"count":5,"href":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/wp-json\/wp\/v2\/pages\/7\/revisions"}],"predecessor-version":[{"id":382,"href":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/wp-json\/wp\/v2\/pages\/7\/revisions\/382"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/wp-json\/wp\/v2\/media\/49"}],"wp:attachment":[{"href":"https:\/\/sites.krieger.jhu.edu\/rokita-lab\/wp-json\/wp\/v2\/media?parent=7"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}