{"id":88,"date":"2016-12-20T21:30:08","date_gmt":"2016-12-20T21:30:08","guid":{"rendered":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/?page_id=88"},"modified":"2016-12-20T22:16:42","modified_gmt":"2016-12-20T22:16:42","slug":"christopher-falzone","status":"publish","type":"page","link":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/people\/christopher-falzone\/","title":{"rendered":"Christopher Falzone"},"content":{"rendered":"<p><span class=\"Header_1\"><strong>Christopher J. Falzone<\/strong><br \/>\n<\/span><\/p>\n<p><span class=\"Normal\">Department of Chemistry<br \/>\nJohns Hopkins University<br \/>\n314 New Chemistry Building<br \/>\n3400 N. Charles St.<br \/>\nBaltimore, MD 21218<br \/>\nPhone: (410) 516-7467<br \/>\nFax: (410) 516-8420<br \/>\nemail: <a href=\"mailto:falzone@jhu.edu\">falzone@jhu.edu<\/a><\/span><\/p>\n<p><strong><span class=\"Header_2\">Education<\/span><\/strong><\/p>\n<ul>\n<li><span class=\"Normal\">A. B. in Chemistry, Washington University (St. Louis)<\/span><\/li>\n<li><span class=\"Normal\">Ph. D. in Chemistry, 1984, Clarkson University (Potsdam, NY)<\/span><\/li>\n<li><span class=\"Normal\">Post-Doctoral Associate, University of Akron<\/span><\/li>\n<li><span class=\"Normal\">Post-Doctoral Associate, The Pennsylvania State University<\/span><\/li>\n<\/ul>\n<p><strong><span class=\"Header_2\">Professional Experience<\/span><\/strong><\/p>\n<ul>\n<li><span class=\"Normal\">1986\u20131987: Director of Nuclear Magnetic Resonance Instrumentation, The University of Akron<\/span><\/li>\n<li><span class=\"Normal\">1992\u2013present: Lecturer, The Pennsylvania State University<\/span><\/li>\n<li><span class=\"Normal\">1992\u2013present: Assistant Director of the Nuclear Magnetic Resonance Facility (Biological Applications), The Pennsylvania State University<\/span><\/li>\n<li><span class=\"Normal\">1997\u2013present: Chemistry Co-op Coordinator, The Pennsylvania State University<\/span><\/li>\n<li><span class=\"Normal\">1997\u2013present: Chemistry Undergraduate Advising Coordinator, The Pennsylvania State University<\/span><\/li>\n<li><span class=\"Normal\">2003\u20132007: Teaching Professor, Chemistry Department, The Pennsylvania State University<\/span><\/li>\n<li><span class=\"Normal\">2007\u2013present: Associate Research Professor, Chemistry Department, Johns Hopkins University<\/span><\/li>\n<\/ul>\n<p><strong><span class=\"Header_2\">Publications<\/span><\/strong><\/p>\n<ul>\n<li><span class=\"Normal\">Antonkine, M.L., Maes, E.M., Czernuszewicz, R.S., Breitenstein, C., Bill, E., Falzone, C.J., Balasubramanian, R., Lubner, C., Bryant, D.A., and Golbeck, J.H. (2007) Chemical rescue of a site-modified ligand to a [4Fe-4S] cluster in PsaC, a bacterial-like dicluster ferredoxin bound to Photosystem I. Biochimica Biophysica Acta 1767:712\u2013724<\/span><\/li>\n<li><span class=\"Normal\">Vuletich, D.A., Falzone, C.J., and Lecomte, J.T.J. (2006) Structural and Dynamic Repercussions of Heme Binding and Heme-Protein Cross-Linking in Synechococcus sp. PCC 7002 Hemoglobin. Biochemistry 45:14075\u201314084.<\/span><\/li>\n<li><span class=\"Normal\">Lecomte, J.T.J., Vu, B.C., and Falzone,C.J. (2005) Structural and Dynamic Properties of Synechocystis sp. PCC 6803 Hb Revealed by Reconstitution with Zn-Protoporphyrin IX. Journal of Inorganic Biochemistry 99:1585\u20131592.<\/span><\/li>\n<li><span class=\"Normal\">Vu, B.C., Nothnagel, H.J., Vuletich, D.A., Falzone, C.J., and Lecomte, J.T.J. (2004) Cyanide Binding to Hexacoordinate Cyanobacterial Hemoglobins: Hydrogen Bonding Network and Heme Pocket Rearrangement in Ferric H117A Synechocystis Hb. Biochemistry, 43:12622\u201312633.\u00a0<\/span><\/li>\n<li><span class=\"Normal\">Vu, B.C., Vuletich, D.A., Kuriakose, S.A., Falzone, C.J., and Lecomte, J.T.J. (2004) Characterization of the Heme-Histidine Cross-link in Cyanobacterial Hemoglobins from Synechocystis sp. PCC 6803 and Synechococcus sp. PCC 7002. Journal of Biological Inorganic Chemistry 9:183\u2013194.<\/span><\/li>\n<li><span class=\"Normal\">Vadrevu, R., Falzone, C.J., and Matthews, C. R. (2003) Partial NMR Assignments and Secondary Structure Mapping of the Isolated a-Subunit of Escherichia coli Tryptophan Synthase, a 29-kD TIM Barrel Protein. Protein Science12:185\u2013191.<\/span><\/li>\n<li><span class=\"Normal\">Proctor, D.J., Schaak, J.E., Bevilacqua, J.M., Falzone C.J., &amp; Bevilacqua, P.C. (2002) Isolation and Characterization of a Family of Stable RNA Tetraloops with the Motif YNMG That Participate in Tertiary Interactions. Biochemistry, 41:12062\u201312075.<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C.J., Vu, B.C., Scott, N.L., and Lecomte, J.T.J. (2002) The Solution Structure of the Recombinant Hemoglobin from the Cyanobacterium Synechocystis sp. PCC 6803 in its Hemichrome State. Journal of Molecular Biology 324:1015\u20131029.<\/span><\/li>\n<li><span class=\"Normal\">Scott, N.L., Falzone, C.J., Vuletich, D.A., Zhao, J., Bryant, D.A., and Lecomte, J.T.J. (2002) Truncated Hemoglobin from the Cyanobacterium Synechococcus sp. PCC 7002: Evidence for Hexacoordination and Covalent Adduct Formation in the Ferric Recombinant Protein. Biochemistry 22:6902\u20136910.\u00a0<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C.J., and Lecomte, J.T.J. (2002) Letter to the Editor: Assignment of the 1H, 13C, and 15N Signals of Synechocystis sp. PCC 6803 Methemoglobin. Journal of Biomolecular NMR 23:71\u201372.\u00a0<\/span><\/li>\n<li><span class=\"Normal\">Lecomte, J.T.J., Scott, N.L., Vu, B.C., and Falzone, C.J. (2001) Binding of Ferric Heme by the Recombinant Globin from the Cyanobacterium Synechocystis sp. PCC 6803. Biochemistry 40:6541\u20136552.\u00a0<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C.J., Wang, Y., Vu, B.C., Scott, N.L., Bhattacharya, S., and Lecomte, J.T.J. (2001) Structural and Dynamic Perturbations Induced by Heme Binding in Cytochrome b<sub>5<\/sub>. Biochemistry 40:4879\u20134891.\u00a0<\/span><\/li>\n<li><span class=\"Normal\">Lecomte, J.T.J., and Falzone, C.J. (1999) Where U and I meet. Nature Structural Biology, 6:605-608.<\/span><\/li>\n<li><span class=\"Normal\">Mayer, K.L., Shen, G., Bryant, D.A., Lecomte, J.T.J., and Falzone, C.J. (1999) The Solution Structure of Photosystem I Accessory Protein E from the Cyanobacterium Nostoc sp. Strain PCC 8009. Biochemistry 38:13736\u201313746.<\/span><\/li>\n<li><span class=\"Normal\">Lecomte, J.T.J., Sukits, S.F., Bhattacharya, S., and Falzone, C.J. (1999) Conformational Properties of Native Sperm Whale Apomyoglobin in Solution. Protein Science 8:1484\u20131491.<\/span><\/li>\n<li><span class=\"Normal\">Bhattacharya, S., Falzone, C.J., and Lecomte, J.T.J. (1999) The Backbone Dynamics of Apocytochrome b<sub>5<\/sub> in Its Native, Partially Folded State. Biochemistry 38:2577\u20132589. doi:10.1021\/bi995081u<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C.J., Mayer, M.R., Whiteman, E.L., Moore, C.D., and Lecomte, J.T.J. (1996) Design Challenges for Hemoproteins: The Solution Structure of Apocytochrome\u00a0b<sub>5<\/sub>. Biochemistry 35:6519\u20136526.\u00a0<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C.J., Kao, Y.-H., Zhao, J., Bryant, D.A., and Lecomte, J.T.J. (1994) Three-Dimensional Solution Structure of PsaE from the Cyanobacterium Synechococcus sp. Strain PCC 7002: a Photosystem I Protein that Shows Structural Homology with SH3 Domains. Biochemistry 33:6052\u20136062. Protein data bank id:\u00a0<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C.J., Kao, Y.-H., Zhao, J., MacLaughlin, K.L., Bryant, D.A., and Lecomte, J.T.J. (1994) 1H and 15N NMR Assignments of PsaE, a Photosystem I Subunit from the Cyanobacterium Synechococcus sp. Strain PCC 7002. Biochemistry 33:6043\u20136051.<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C.J. Wright, P.E. and Benkovic, S.J. (1994) Dynamics of a Flexible Loop in Dihydrofolate Reductase from Escherichia coli by Site-directed Mutagenesis. Biochemistry 33:439-442.<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C.J., Cavanagh, J., Cowart, M., Palmer, A.G. III, Matthews, C. R., Benkovic, S.J. and Wright, P.E. (1994) The <sup>1<\/sup>H, <sup>15<\/sup>N, and <sup>13<\/sup>C Resonance Assignments, Secondary Structure, and the Conformation of Substrate in the Binary Folate Complex of Escherichia coli Dihydrofolate Reductase. Journal of Biomolecular NMR 4:349-366.<\/span><\/li>\n<li><span class=\"Normal\">Cowart, M., Falzone, C. J., and Benkovic, S. J. (1994) A New Synthesis of Double Labeled [7,9\u2013 <sup>13<\/sup>C2] Folic Acid. Journal of Labelled Compounds and Radio-pharmaceuticals 34:67\u201371.<\/span><\/li>\n<li><span class=\"Normal\">Benesi, A., J., Falzone, C. J., Banerjee, S., and Farber, G. K. (1994) NMR Assignments for the Aldopentoses. Carbohydrate Research 258:27\u201333.<\/span><\/li>\n<li><span class=\"Normal\">Iwakura, M., Jones, B. E., Falzone, C. J., and Matthews, C. R. (1993) Collapse of Parallel Folding Channels in Dihydrofolate Reductase from Escherichia coli by Site\u2013Directed Mutagenesis. Biochemistry 32:13566\u201313574.<\/span><\/li>\n<li><span class=\"Normal\">Li, L., Falzone, C. J., Wright, P. E., and Benkovic, S. J. (1992) Functional Role of a Mobile Loop of Escherichia coli Dihydrofolate Reductase in Transition State Stabilization. Biochemistry 31:7826\u20137833.<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C.J., Benesi, A.J., and Lecomte, J.T.J. (1992) Characterization of Taxol in Methylene Chloride by NMR Spectroscopy. Tetrahedron Letters 33:1169\u20131172.<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C. J., Wright, P. E., and Benkovic, S. J. (1991) Evidence for Two Interconverting Protein Isomers in the Methotrexate Complex of Dihydrofolate Reductase from Escherichia coli. Biochemistry 30:2184\u20132191.<\/span><\/li>\n<li><span class=\"Normal\">Wilson, G. E., Falzone, C. J., and Dong, H. (1990) GDP and GTP Association Equilibria. Use of Manganous Ion Induced Paramagnetic Relaxation Rates to Study Hydrogen\u2013Bonded Species. Journal of the American Chemical Society 112:8269\u20138273.<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C. J., Benkovic, S. J., and Wright, P. E. (1990) Partial <sup>1<\/sup>H NMR Assignments of the Escherichia coli Dihydrofolate Reductase Complex with Folate: Evidence for a Unique Conformation of Bound Folate. Biochemistry 29: 9667\u20139677.<\/span><\/li>\n<li><span class=\"Normal\">Falzone, C. J., Karsten, W. E., Conley, J. D., and Viola, R. E., (1988) L\u2013Aspartase from Escherichia coli: Substrate Specificity and the Role of Divalent Metal Ions. Biochemistry 27:9089\u20139093.<\/span><\/li>\n<li><span class=\"Normal\">Guterman, L. R., Falzone, C. J., Wilson, G. E., Jr. (1986) Action of Hydrochloric Acid on Aluminum Hydroxide-Magnesium Hydroxide Gels and Magaldrate: Quasi-elastic Light Scattering Studies. Journal of Pharmaceutical Sciences 75:502\u2013505.<\/span><\/li>\n<li><span class=\"Normal\">Wilson, G. E., Jr., Falzone, C. J., Lee, H. K., and Johnson, R. (1985) The Action of Hydrochloric Acid on Aluminum Hydroxide\u2013Magnesium Hydroxide Gels and Magaldrate: <sup>27<\/sup>Al NMR and pH-stat Studies. Journal of Pharmaceutical Sciences 74:1075\u20131077.<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Christopher J. Falzone Department of Chemistry Johns Hopkins University 314 New Chemistry Building 3400 N. Charles St. Baltimore, MD 21218 Phone: (410) 516-7467 Fax: (410) 516-8420 email: falzone@jhu.edu Education A. B. in Chemistry, Washington University (St. Louis) Ph. D. in Chemistry, 1984, Clarkson University (Potsdam, NY) Post-Doctoral Associate, University of Akron Post-Doctoral Associate, The Pennsylvania [&hellip;]<\/p>\n","protected":false},"author":52,"featured_media":0,"parent":5,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-88","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/wp-json\/wp\/v2\/pages\/88","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/wp-json\/wp\/v2\/users\/52"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/wp-json\/wp\/v2\/comments?post=88"}],"version-history":[{"count":3,"href":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/wp-json\/wp\/v2\/pages\/88\/revisions"}],"predecessor-version":[{"id":96,"href":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/wp-json\/wp\/v2\/pages\/88\/revisions\/96"}],"up":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/wp-json\/wp\/v2\/pages\/5"}],"wp:attachment":[{"href":"https:\/\/sites.krieger.jhu.edu\/lecomte-lab\/wp-json\/wp\/v2\/media?parent=88"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}