Understanding the molecular mechanisms of how cells read, write and repair the genome
We aim to elucidate the molecular mechanisms through which large, multi-subunit complexes engage in DNA-centric processes, utilizing cryo-electron microscopy (cryo-EM) alongside biochemical, biophysical and genomic methods. Our research centers on two main areas: the regulation of eukaryotic gene transcription at various stages, and the repair of different types of DNA damage, exploring how deficiencies in these pathways contribute to cancer predisposition or accelerated aging.
Welcome to the He lab!
