{"id":890,"date":"2021-02-13T14:27:56","date_gmt":"2021-02-13T14:27:56","guid":{"rendered":"https:\/\/sites.krieger.jhu.edu\/greenberg\/?page_id=890"},"modified":"2025-09-19T15:29:46","modified_gmt":"2025-09-19T15:29:46","slug":"2021-present","status":"publish","type":"page","link":"https:\/\/sites.krieger.jhu.edu\/greenberg\/publications\/2021-present\/","title":{"rendered":"2021 – present"},"content":{"rendered":"\n

223. Identifying Poly(ADP-ribose)-Binding Proteins With Photoaffinity-Based Proteomics. Dasovich, M.; Beckett, M. Q.; Bailey, S.; Ong, S.; Greenberg, M. M.; Leung, A. K. L. J. Am. Chem. Soc. <\/em>2021<\/strong>, 143<\/em>, 3037-3042.      <\/p>\n\n\n\n

224. Selective Inhibition of DNA Polymerase b by a Covalent Inhibitor. Yuhas, S. C.; Laverty, D. J.; Lee, H.; Greenberg, M. M. J. Am. Chem. Soc. <\/em>2021<\/strong>, 143<\/em>, 8099-8107.<\/p>\n\n\n\n

225. Sequence Context Effects of Replication of Fapy\u2022dG in Three Mutational Hot Spot Sequences of the p53 Gene in Human Cells. Bacurio, J. H.; Yang, H.; Naldiga, S.; Powell, B. V.; Ryan, B. J.; Freudenthal, B. D.; Greenberg, M. M. Basu, A. K. DNA Repair <\/em>2021<\/strong>, 108<\/em>, 103213.<\/p>\n\n\n\n

226. Protein Domain Specific Covalent Inhibition of Human DNA Polymerase b. Yuhas, S. C.; Majumdar, A.; Greenberg, M. M. ChemBioChem<\/em> <\/strong>2021<\/strong>, 22<\/em>, 2619-2623. Designated by the editor as a Very Important Paper<\/em>.<\/p>\n\n\n\n

227. Suppression of DNA Polymerase b Activity is Synthetically Lethal in BRCA1-Deficient Cells.             Yuhas, S. C.; Mishra, A.; DeWeese, T. L.; Greenberg, M. M. ACS Chem. Biol<\/em>. ACS Chem. Biol<\/em>. 2021<\/strong>, 16<\/em>, 1339-1343.<\/p>\n\n\n\n

228. Reactivity and DNA Damage by Independently Generated 2′-Deoxycytidin-N<\/em>4-yl Radical. <\/a>            Peng, H.; Jialong, J.; Mortimer, I. P.; Zehan, M.; Su, H.; Greenberg, M. M. J. Am. Chem. Soc. <\/em>2021<\/strong>, 143<\/em>, 14738-14747.<\/p>\n\n\n\n

229. Intracellular Formation of A DNA Damage-Induced, Histone Post-translational Modification Following Bleomycin Treatment. <\/a>Jacinto, M. P.; Fried, S. D.; Greenberg, M. M. Jacinto, M. P.;<\/em> Fried, S. D.; Greenberg, M. M. J. Am. Chem. Soc.<\/em> 2022<\/strong>, 144<\/em>, 7600-7605.<\/p>\n\n\n\n

230. Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and During DNA Replication.<\/a> Ryan, B. J.; Yang, H.; Bacurio, J.H.; Smith, M. R.; Basu, A. K.; Greenberg,M. M.; Freudenthal, B. D. J. Am. Chem. Soc. <\/em>2022<\/strong>, 144<\/em>, <\/em>8054-8065.<\/p>\n\n\n\n

231. Local Alteration of Ionic Strength in a Nucleosome Core Particle and its Effect on N<\/em>7-Methyl-2\u2019-deoxyguanosine Depurination.<\/a> Wen, T.; Yang, K.; Greenberg, M. M. Biochemistry <\/em>2022<\/strong>, 61<\/em>, 2221-2228.<\/p>\n\n\n\n

232. Covalent Modification of Bromodomain Proteins by Peptides Containing a DNA Damage-Induced, Histone Post-Translational Modification.<\/a> Jacinto, M. P.; Heidenreich, D.; M\u00fcller, S.; Greenberg, M. M. ChemBioChem <\/em>2022<\/strong>, 23<\/em>, e202200373.<\/p>\n\n\n\n

233. Histone Deacetylase 1 Inhibition by Peptides Containing a DNA Damage-Induced, Non-enzymatic, Histone Covalent Modification.<\/a> Jacinto, M. P.; Greenberg, M. M. Biochemistry <\/em>2023<\/strong>, 62<\/em>, 1388-1393. <\/p>\n\n\n\n

234. 8-Oxo-2\u2019-deoxyguanosine Replication in Mutational Hot Spot Sequences of the p53<\/em> Gene in Human Cells is Less Mutagenic Than That of the Corresponding Formamidopyrimidine.<\/a> Stanio, S.; Bacurio, J. H.; Yang, H.; Greenberg, M. M.; Basu, A. K. Chem. Res. Toxicol. <\/em>2023<\/strong>, 36<\/em>, 782-789.<\/p>\n\n\n\n

235. Photochemical and Single Electron Transfer Generation of 2\u00a2-Deoxycytidin-N4-yl Radical From Oxime Esters. Peng, H.; Vu, S.; Retes, P.; Ward, S.; Kumar, A.; Sevilla, M. D.; Adhikary, A.; Greenberg, M. M. J. Org. Chem.<\/em> 2023<\/strong>, 88<\/em>, 7381-7390.<\/p>\n\n\n\n

236. Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding. Egleston, M.; Dong, L; Howlader, A. H.; Bhat, S.; Orris, B.; Bianchet, M.; Greenberg, M. M.; Stivers, J. T. ACS Chem. Biol.<\/em> 2023<\/strong>, 18<\/em>, 2200-2210.<\/a><\/p>\n\n\n\n

237. Synergistic Effects on the Mutagenicity of Tandem Lesions Containing 8-Oxo-7,8-dihydro-2\u02b9-deoxyguanosine or Fapy\u2022dG Flanked by a 3\u02b9 5-Formyl-2\u02b9-deoxyuridine in Human Cells.<\/a> Bacurio, J. H.; Gao, S.; Yang, H.; Basu, A. K.; Greenberg, M. M. DNA Repair <\/em>2023<\/strong>, 129<\/em>, 103527.<\/p>\n\n\n\n

238. DNA-Histone Cross-link Formation via Hole Trapping in Nucleosome Core Particles.<\/a> Wen, T.; Kermarrec, M.; Dumont, E.; Gillet, N.; Greenberg, M. M. J. Am. Chem. Soc. <\/em>2023<\/strong>, 145<\/em>, 23702-23714.<\/p>\n\n\n\n

239. Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy\u2022dG. Gao, S.; Hou, P.; Oh, J.; Wang, D.; Greenberg, M. M. J. Am. Chem. Soc. <\/em>2024<\/strong>, 146<\/em>, 6274-6282.<\/p>\n\n\n\n

240. Biochemical and Structural Characterization of Fapy\u2022dG Replication by Human DNA Polymerase b. Gao, S.; Oden, P. N.; Ryan, B. J.; Yang, H.; Freudenthal, B. D.; Greenberg, M. M. Nucleic Acids Res<\/em> <\/strong>2024<\/strong>, 52<\/em>, 5392-5405.<\/p>\n\n\n\n

241. DNA-Protein Cross-Links With N7-Methyl-2\u2019-deoxyguanosine And Their Contribution To Cytotoxicity. Wen, T.; Zhao, S.; Stingele, J.; Ravanat, J.; Greenberg, M. M. Chem. Res. Toxicol. <\/em>2024<\/strong>, 37<\/em>, 814-823.<\/p>\n\n\n\n

242. Promoter Dependent RNA Polymerase II Bypass of the Epimerizable DNA Lesion, Fapy\u2022dG and 8-Oxo-2′-deoxyguanosine. Gao, S.; Tahara, Y.; Kool, E. T.; Greenberg, M. M. Nucleic Acids Res. <\/em>2024<\/strong>, 52<\/em>, 7437-7446.<\/p>\n\n\n\n

243. T7 RNA Polymerase Catalyzed Transcription of the Epimerizable DNA Lesion, Fapy\u2022dG and 8-Oxo-2′-deoxyguanosine.<\/a>  Gao, S.; Hou, P.; Wang, D.; Greenberg, M. M. J. Biol. Chem. <\/em>2024<\/strong>, 300<\/em>, 107719.<\/p>\n\n\n\n

244.  8-OxodGuo and Fapy\u2022dG Mutagenicity in Escherichia coli<\/em> Increases Significantly When They are Part of a Tandem Lesion With 5-Formyl-2\u02b9-deoxyuridine. Dasgupta, S.; Gao, S.; Yang, H.; Greenberg, M. M.; Basu, A. K. Chem. Res. Toxicol.<\/em> 2024<\/strong>, 37<\/em>, 1445-1452.<\/p>\n\n\n\n

245. A Human High-Fidelity DNA Polymerase Holoenzyme Has a Wide Range of Lesion Bypass Activities.<\/a> Dannenberg, R. L.; Cardina, J. A.; Washington, H.; Gao, S.; Greenberg, M. M.; Hedglin, M. Nucleic Acids Res.<\/em>2025<\/strong>, 53<\/em>, gkaf646.<\/p>\n\n\n\n

246. Inhibitors of SAMHD1 Obtained From Chemical Tethering to the Guanine Antiviral Acyclovir<\/a>. Egleston, M.; Bhat, S.; Howlader, A. H.; Bianchet, M. A.; Liu, Y.; Lopez Rovira, L. M.; Smith, B.; Greenberg, M. M.; Stivers, J. T. Biochemistry <\/em>2025<\/strong>, 64<\/em>, 1109-1120.<\/p>\n\n\n\n

247. Uridine Embedded Within DNA is Repaired by Uracil DNA Glycosylase via a Mechanism Distinct From That of RNase H2<\/a>.            Fan, C.; Zhan, X.; Guo, F.; Li, Q.; Lu, K.; Shan, X.; Zhou, Y.; Ren, M.; Greenberg, M. M.; Liu Y.; Zhou, C. J. Am. Chem. Soc. <\/em>2025<\/strong>, 147<\/em>, 11574-11583.<\/p>\n\n\n\n

248. A Chimeric Bis-Electrophile for Selective DNA-Protein Cross-Linking Reveals an Unknown Source of Nitrogen Mustard Cytotoxicity.<\/a>  Jiang, X.; Vu, S.; Yu, H.; Greenberg, M. M. J. Am. Chem. Soc. <\/em>2025<\/strong>, 147<\/em>, 31839-31848.<\/p>\n\n\n\n

\u00a0\u00a0249.\u00a0Inhibition of DNA Polymerase \u03b2 by a Noncompetitive Inhibitor.<\/a>\u00a0Howlader, A.\u00a0H.; Jiang, X.; Zhou, Z.; Greenberg, M. M.\u00a0J. Org. Chem.\u00a0<\/em>2025<\/strong>,\u00a090<\/em>, 12849-12859. (PMC: 12431629)\u00a0Selected as a Featured Article in the Journal by the Editors. Featured as an\u00a0<\/em>ACS Editors\\’ Choice<\/em><\/a>. The ACS Editors\\’ Choice initiative highlights one article each day that is chosen from the entire ACS portfolio.<\/em><\/p>\n\n\n\n\n","protected":false},"excerpt":{"rendered":"

223. Identifying Poly(ADP-ribose)-Binding Proteins With Photoaffinity-Based Proteomics. Dasovich, M.; Beckett, M. Q.; Bailey, S.; Ong, S.; Greenberg, M. M.; Leung, A. K. L. J. Am. Chem. Soc. 2021, 143, 3037-3042.      224. Selective Inhibition of DNA Polymerase b by a Covalent Inhibitor. Yuhas, S. C.; Laverty, D. J.; Lee, H.; Greenberg, M. M. J. Am. Chem. […]<\/p>\n","protected":false},"author":124,"featured_media":0,"parent":7,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-890","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/pages\/890","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/users\/124"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/comments?post=890"}],"version-history":[{"count":5,"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/pages\/890\/revisions"}],"predecessor-version":[{"id":1309,"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/pages\/890\/revisions\/1309"}],"up":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/pages\/7"}],"wp:attachment":[{"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/media?parent=890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}