{"id":147,"date":"2016-06-15T19:05:00","date_gmt":"2016-06-15T19:05:00","guid":{"rendered":"https:\/\/sites.krieger.jhu.edu\/greenberg\/?page_id=147"},"modified":"2016-07-26T20:25:59","modified_gmt":"2016-07-26T20:25:59","slug":"2000-2005","status":"publish","type":"page","link":"https:\/\/sites.krieger.jhu.edu\/greenberg\/2000-2005\/","title":{"rendered":"2000-2005"},"content":{"rendered":"
    \n
  1. Investigation of the Origin of the Sequence Selectivity for the 5-Halo-2′-deoxyuridine Sensitization of DNA to Damage by UV-Irradiation. Chen, T.; Cook, G. P.; Koppisch, A. T.; Greenberg, M. M. J. Am. Chem. Soc. 2000, 122, 3861.<\/li>\n
  2. Independent Generation and Reactivity of 2′-Deoxy-5-methyleneuridin-5-yl, a Significant Reactive Intermediate Produced From Thymidine as a Result of Oxidative Stress. Anderson, A. S.; Hwang, J. -T.; Greenberg, M. M. J. Org. Chem. 2000, 65, 4648.<\/li>\n
  3. Chemical Evidence for Thiyl Radical Addition to the C6-Position of a Pyrimidine Nucleoside and its Possible Relevance to DNA Damage Amplification. Carter, K. N.; Taverner, T.; Schiesser, C. H.; Greenberg, M. M. J. Org. Chem. 2000, 65, 8375.<\/li>\n
  4. AlkA Protein is the Third Escherichia Coli Protein Excising a Ring Fragmentation Product of Thymine. Privezentzev, C. V.; Saparbaev, M.; Sambandam, A.; Greenberg, M. M.; Laval, J. Biochemistry 2000, 39, 14263.<\/li>\n
  5. Synthesis and Deprotection of Oligonucleotides Under Aprotic Conditions. Chen, T. C.; Fu, J.; Greenberg, M. M. Organic Letters 2000, 2, 3691.<\/li>\n
  6. Synthesis of 2′-Modified Oligodeoxynucleotides via On-Column Conjugation. Hwang, J. -T.; Greenberg, M. M. J. Org. Chem. 2001, 66, 363.<\/li>\n
  7. The 2-Deoxyribonolactone Lesion Produced in DNA by Neocarzinostatin and Other Damaging Agents Forms Cross-Links with the Base-Excision Repair Enzyme Endonuclease III. Hashimoto, M.; Greenberg, M. M.; Kow, Y. W.; Hwang, J.-T.; Cunningham, R. P. J. Am. Chem. Soc. 2001, 123, 3161.<\/li>\n
  8. Product Studies and Laser Flash Photolysis on Alkyl Radicals Containing Two Different \uf062-Leaving Groups are Consonant with the Formation of an Olefin Cation Radical. Bales, B. C.; Horner, J. H.; Huang, X.; Newcomb, M.; Crich, D.; Greenberg, M. M. J. Am. Chem. Soc. 2001, 123, 3623.<\/li>\n
  9. Oxygen Dependent DNA Damage Amplification Involving 5,6-Dihydrothymidin-5-yl in a Structurally Minimal System. Tallman, K. A.; Greenberg, M. M. J. Am. Chem. Soc. 2001, 123, 5181.<\/li>\n
  10. Observation and Elimination of N-Acetylation of Oligonucleotides Prepared Using Fast Deprotecting Phosphoramidites and Ultra-Mild Deprotection. Zhu, Q.; Delaney, M. O.; Greenberg, M. M. Bioorganic & Med. Chem. Lett. 2001, 11, 1105.<\/li>\n
  11. Direct Measurement of Pyrimidine C6-Hydrate Stability. Carter, K. N.; Greenberg, M. M. Bioorganic & Med. Chem. 2001, 9, 2341.<\/li>\n
  12. Synthesis of Oligonucleotides Containing Fapy\u2022dG (N6-(2-Deoxy-\uf061,\uf062-D-erythro-pento-furanosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine). Haraguchi, K.; Greenberg, M. M. J. Am. Chem. Soc. 2001, 123, 8636.<\/li>\n
  13. Template Free Segmental Synthesis of Oligonucleotides Containing Nonnative Linkages. Greenberg, M. M.; Kahl, J. D. J. Org. Chem. 2001, 66, 7151.<\/li>\n
  14. Studies on N4-(2-Deoxy-D-pentofuranosyl)-4,6-diamino-5-formamidopyrimidine (Fapy\u2022dA) and N6-(2-Deoxy-D-pentofuranosyl)- 6-diamino-5-formamido-4-hydroxypyrimidine (Fapy\u2022dG) Greenberg, M. M.; Hantosi, Z.; Wiederholt, C. J.; Rithner, C. D. Biochemistry 2001, 40, 15856.<\/li>\n
  15. Repair of Oxidized Purines and Damaged Pyrimidines by E. coli Fpg Protein. Different Roles of Proline-2 and Lysine-57 Residues. Saparbaev, M.; Sidorkina, O. M.; Jurado, J.; Privezentzev, C. V.; Greenberg, M. M.; Laval, J. Environmental and Molecular Mutagenesis 2002, 39, 10.<\/li>\n
  16. Synthesis and Characterization of Oligodeoxynucleotides Containing Formamidopyrimidine Lesions and Nonhydrolyzable Analogues. Haraguchi, K.; Delaney, M. O.; Wiederholt, C. J.; Sambandam, A.; Hantosi, Z.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 3263.<\/li>\n
  17. Covalent Trapping of Human DNA Polymerase \uf062\uf020by the Oxidative DNA Lesion 2-Deoxyribonolactone. DeMott, M. S.; Beyret, E.; Bales, B. C.; Hwang, J. T.; Greenberg, M. M.; Demple, B. J. Biol. Chem. 2002, 277, 7637.<\/li>\n
  18. Fapy\u2022dA Induces Nucleotide Misincorporation Translesionally by a DNA Polymerase. Delaney, M. O.; Wiederholt, C. J.; Greenberg, M. M. Angew. Chem. Int. Ed. 2002, 41, 771.<\/li>\n
  19. Fapy\u2022dG Instructs Klenow Exo- to Misincorporate Deoxyadenosine. Wiederholt, C. J.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 7278.<\/li>\n
  20. A Minor Groove Binding Copper-Phenanthroline Conjugate Produces Direct Strand Breaks Via \uf062-Elimination of 2-Deoxyribonolactone. Bales, B. C.; Pitie, M.; Meunier, B.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 9062.<\/li>\n
  21. Synthesis of Oligonucleotides and Thermal Stability of Duplexes Containing the \uf062-C-Nucleoside Analogue of Fapy\u2022dG. Delaney, M. O.; Greenberg, M. M. Chem. Res. Toxicol. 2002, 15, 1460.<\/li>\n
  22. Interaction of DNA Containing Fapy\u2022dA or its C-Nucleoside Analogues with Base Excision Repair Enzymes. Implications for Mutagenesis and Enzyme Inhibition. Wiederholt, C. J.; Delaney, M. O.; Greenberg, M. M. Biochemistry 2002, 41, 15838.<\/li>\n
  23. Action of Human Apurinic Endonuclease (Ape1) on C1′-Oxidized Deoxyribose Damage in DNA. Xu, Y.; DeMott, M. S.; Hwang, J. T.; Greenberg, M. M.; Demple, B. DNA Repair 2003, 2, 175.<\/li>\n
  24. Transcription Inhibition Using Modified Pentanucleotides. Hwang, J. T.; Baltasar, F. E.; Cole, D.; Sigman, D. S.; Chen, C. B.; Greenberg, M. M. Bioorganic & Med. Chem. 2003, 11, 2321.<\/li>\n
  25. Cross-linking of 2-Deoxyribonolactone and its \uf062-Elimination Product by Base Excision Repair Enzymes. Kroeger, K. M.; Hashimoto, M.; Kow, Y. W.; Greenberg, M. M. Biochemistry 2003, 42, 2449.<\/li>\n
  26. Independent Generation and Study of 5,6-Dihydro-2′-deoxyuridin-6-yl. A Member of the Major Family of Reactive Intermediates Formed in DNA from the Effects of \uf067-Radiolysis. Carter, K. N.; Greenberg, M. M. J. Org. Chem. 2003, 68, 4275.<\/li>\n
  27. Synthesis of 5,12-Dioxocyclam Nickel (II) Complexes Having Quinoxaline Substituents at the 6 and 13 Positions as Potential DNA Bis-Intercalating and Cleaving Agents. Hegedus, L. S.; Greenberg, M. M.; Wendling, J. J.; Bullock, J. P. J. Org. Chem. 2003, 68, 4179.<\/li>\n
  28. Synthesis and Characterization of Oligonucleotides Containing the C4′-Oxidized Abasic Site Produced by Bleomycin and Other DNA Damaging Agents. Kim, J.; Gil, J. M.; Greenberg, M. M. Angew. Chem. Int. Ed. Engl. 2003, 42, 5882.<\/li>\n
  29. Repair of DNA Containing Fapy\u2022dG and its \uf062-C-Nucleoside Analogue by Formamidopyrimidine DNA Glycosylase and MutY. Wiederholt, C. J.; Delaney, M. O.; Pope, M. A.; David, S. S.; Greenberg, M. M. Biochemistry 2003, 42, 9755.<\/li>\n
  30. Tandem Lesions are the Major Products Resulting From a Pyrimidine Nucleobase Radical. Carter, K. N.; Greenberg, M. M. J. Am. Chem. Soc. 2003, 125, 13376.<\/li>\n
  31. In Vitro Effects of a C4′-Oxidized Abasic Site on DNA Polymerases. Greenberg, M. M.; Weledji, Y. N.; Kroeger, K. M.; Kim, J.; Goodman, M. F. Biochemistry 2004, 43, 2656.<\/li>\n
  32. Mutagenic Effects of 2-Deoxyribonolactone in E. coli. An Abasic Lesion that Disobeys the A-Rule. Kroeger, K. M.; Jiang, Y.; Kow, Y. W.; Goodman, M. F.; Greenberg, M. M. Biochemistry 2004, 43, 6723.<\/li>\n
  33. Repair of Oxidized Abasic Sites by Exonuclease III, Endonuclease IV, and Endonuclease III. Greenberg, M. M.; Weledji, Y. N.; Kim, J.; Bales, B. C. Biochemistry 2004, 43, 8178.<\/li>\n
  34. Evidence for Glycosidic Bond Rotation in a Nucleobase Peroxyl Radical and its Effect on Tandem Lesion Formation. Hong, I. S.; Carter, K. N.; Greenberg, M. M. J. Org. Chem. 2004, 69, 6974.<\/li>\n
  35. Probing the Configurations of Formamidopyrimidines (Fapy\u2022dA, Fapy\u2022dG) in DNA Using Endonuclease IV. Patro, J.; Haraguchi, K.; Delaney, M. O.; Greenberg, M. M. Biochemistry 2004, 43, 13397.<\/li>\n
  36. Independent Generation and Characterization of a C2′-Oxidized Abasic Site in Chemically Synthesized Oligonucleotides. Kim, J.; Weledji, Y. N.; Greenberg, M. M. J. Org. Chem. 2004, 69, 6100.<\/li>\n
  37. Effects of the C4′-Oxidized Abasic Site on Replication in E. coli. Unusually Large Deletions are Induced by a Small Lesion. Kroeger, K. M.; Kim, J.; Goodman, M. F.; Greenberg, M. M. Biochemistry 2004, 43, 13621.<\/li>\n
  38. A Comprehensive Comparison of DNA Replication Past 2-Deoxyribose and its Tetrahydrofuran Analogue in E. Coli. Kroeger, K. M.; Goodman, M. F.; Greenberg, M. M. Nucleic Acids Res. 2004, 32, 5480.<\/li>\n
  39. In Vitro Replication and Repair of DNA Containing a C2′-Oxidized Abasic Site. Greenberg, M. M.; Weledji, Y. N.; Kroeger, K. M.; Kim, J. Biochemistry 2004, 43, 15217.<\/li>\n
  40. Mild Thermal Generation of 5-(2′-Deoxyuridinyl)methyl Radical From a Phenyl Selenide Precursor. Hong, I. S.; Greenberg, M. M. Org. Lett. 2004, 6, 5011.<\/li>\n
  41. Synthesis of Oligonucleotides Containing Fapy\u2022dG (N-(2-Deoxy-\uf061,\uf062-D-erythropentofuranosyl)-N-(2,6-diamino-4-hydroxy-5-formamidopyrimidine)) Using a 5′-Dimethoxytrityl Dinucleotide Phosphoramidite. Jiang, Y.; Wiederholt, C. J.; Patro, J. N.; Haraguchi, K.; Greenberg, M. M. J. Org. Chem. 2005, 70, 141.<\/li>\n
  42. Selective Detection of 2-Deoxyribonolactone in DNA. Sato, K.; Greenberg, M. M. J. Am. Chem. Soc. 2005, 127, 2806.<\/li>\n
  43. Efficient DNA Interstrand Cross-Link Formation From a Nucleotide Radical. Hong, I. S.; Greenberg, M. M. J. Am. Chem. Soc. 2005, 127, 3692.<\/li>\n
  44. The Effect of the 2-Amino Group of 7,8-Dihydro-8-Oxo-2′-Deoxyguanosine on Translesion Synthesis and Duplex Stability. Oka, N.; Greenberg, M. M. Nucleic Acids Res. 2005, 33, 1637.<\/li>\n
  45. Excision of Formamidopyrimidine Lesions by Endonucleases III and VIII is Not a Major DNA Repair Pathway in E. coli. Wiederholt, C. J.; Patro, J. N.; Jiang, Y.; Haraguchi, K.; Greenberg, M. M. Nucleic Acids Res. 2005, 33, 3331.<\/li>\n
  46. Mechanistic Studies on DNA Damage by Minor Groove Binding Copper-Phenanthroline Conjugates. Bales, B. C.; Kodama, T.; Weledji, Y. N.; Piti\u00e9, M.; Meunier, B.; Greenberg, M. M. Nucleic Acids Res. 2005, 33, 5371.<\/li>\n
  47. Preparation and Analysis of Oligonucleotides Containing the C4′-Oxidized Abasic Site and Related Mechanistic Probes. Kim, J.; Kreller, C. R.; Greenberg, M. M. J. Org. Chem. 2005, 70, 8122.<\/li>\n
  48. DNA Interstrand Cross-link Formation Initiated by Reaction Between Singlet Oxygen and a Modified Nucleotide. Hong, I. S.; Greenberg, M. M. J. Am. Chem. Soc. 2005, 127, 10510.<\/li>\n
  49. Preparation and Analysis of Oligonucleotides Resulting From C5′-Oxidation. Kodama, T.; Greenberg, M. M. J. Org. Chem. 2005, 70, 9916.<\/li>\n
  50. Mutagenic Effects of Abasic and Oxidized Abasic Lesions in Saccharomyces cerevisiae. Kow, Y. W.; Bao, G.; Minesinger, B.; Jinks-Robertson, S.; Siede, W.; Jiang, Y. L.; Kim, J.; Greenberg, M. M. Nucleic Acids Res. 2005, 33, 6196.<\/li>\n
  51. Repair of Formamidopyrimidines in DNA Involves Different Glycosylases. Hu, J.; de Souza-Pinto, N. C.; Haraguchi, K.; Hogue, B. A.; Jaruga, P.; Greenberg, M. M.; Dizdaroglu, M.; Bohr, V. A. J. Biol. Chem. 2005, 280, 40544.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Investigation of the Origin of the Sequence Selectivity for the 5-Halo-2′-deoxyuridine Sensitization of DNA to Damage by UV-Irradiation. Chen, T.; Cook, G. P.; Koppisch, A. T.; Greenberg, M. M. J. Am. Chem. Soc. 2000, 122, 3861. Independent Generation and Reactivity of 2′-Deoxy-5-methyleneuridin-5-yl, a Significant Reactive Intermediate Produced From Thymidine as a Result of Oxidative Stress. […]<\/p>\n","protected":false},"author":40,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-147","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/pages\/147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/users\/40"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/comments?post=147"}],"version-history":[{"count":5,"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/pages\/147\/revisions"}],"predecessor-version":[{"id":328,"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/pages\/147\/revisions\/328"}],"wp:attachment":[{"href":"https:\/\/sites.krieger.jhu.edu\/greenberg\/wp-json\/wp\/v2\/media?parent=147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}