Publications

Meng X, Kao JPY, Lee H-K, and Kanold PO. (2017) Intracortical circuits in thalamorecipient layers of auditory cortex refine after visual deprivation. eNeuro 0092-17. PDF Document: View PDF file

Keck T, Toyoizumi T, Chen L, Boiron B, Feldman DE, Fox K, Gerstner W, Haydon PG, Hubener M, Lee H-K, Lisman JE, Rose T, Sengpiel F, Stellwagen D, Stryker MP, Turrigiano GG, and van Rossum MC. (2017) Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philosophical Transactions of the Royal Society B. 372 (1715): 20160158. PDF Document: View PDF file

Gao M*, Whitt JL*, Huang S*, Lee A, Mihalas S, Kirkwood A, and Lee H-K. (2017) Experience-dependent homeostasis of “noise” at inhibitory synapses preserves information coding in adult visual cortex. Philosophical Transactions of the Royal Society B. 372 (1715): 20160156. PDF Document: View PDF file

Lee H-K. (2016) Talk louder so I can see you. Neuron 89: 887-888. PDF Document: View PDF file

Lee H-K and Whitt JL. (2015) Cross-modal synaptic plasticity in adult primary sensory cortices. Current Opinion in Neurobiology 74 (3): 119-126. PDF Document: View PDF file

Meng X, Kao JPY, Lee H-K, and Kanold PO. (2015) Visual deprivation causes refinement of intracortical circuits in the auditory cortex. Cell Reports 12 (6): 955-964. PDF Document: View PDF file

Megill A, Tran T, Eldred K, Lee NJ, Wong PC, Hoe H-S, Kirkwood A, and Lee H-K. (2015) Defective age-dependent metaplasticity in a mouse model of Alzheimer’s disease. Journal of Neuroscience 35 (32): 11346-11357. PDF Document: View PDF file

Petrus E, Rodriguez G, Patterson R, Connor B, Kanold PO, and Lee H-K. (2015) Vision loss shifts the balance of feedforward and intracortical circuits in opposite directions in mouse primary auditory and visual cortices. Journal of Neuroscience 35 (23): 8790-8801. PDF Document: View PDF file

Gao M, Maynard KR, Chokshi V, Song L, Jacobs C, Wang H, Tran T, Martinowich K, and Lee H-K. (2014) Rebound potentiation of inhibition in juvenile visual cortex requires vision-induced BDNF expression. Journal of Neuroscience 34(32): 10770-10779. PDF Document: View PDF file

Huang S, Rozas C, Trevino M, Contreras J, Yang S, Song L, Yoshioka T, Lee H-K, and Kirkwood A. (2014) Associative Hebbian synaptic plasticity in primate visual cortex. Journal of Neuroscience 34 (22): 7575-7579. PDF Document: View PDF file

Petrus E and Lee H-K. (2014) BACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortex. Neural Plasticity 2014: 128631. Web Access

Wang H, Megill A, Wong PC, Kirkwood A, and Lee H-K. (2014) Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice. PLoS One 9 (30): e92279. Web Access

Petrus E*, Isaiah A*, Jones AP, Li D, Wang H, Lee H-K, and Kanold PO. (2014) Cross-modal induction of thalamocortical potentiation leads to enhanced information processing in the auditory cortex. Neuron 81: 664-673. PDF Document: View PDF file and PDF Document: Supplementary file

Whitt JL*, Petrus E*, and Lee H-K. (2014) Experience-dependent homeostatic synaptic plasticity in neocortex. Neuropharmacology 78 (2014): 45-54. PDF Document: View PDF file

Song JM*, DiBattista AM*, Sung YM, Ahn JM, Turner RS, Yang J, Pak DTS, Lee H-K, and Hoe H-S. (2014) A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer’s disease. Experimental Neurology 252 (2014): 105-113. PDF Document: View PDF file

Ikar T, Guo N, He K, Besnard AS, Ievenson S, Hill A, Lee H-K, Hen R, Xu X, and Sahay A. (2013) Adult neurogenesis modulates excitability of the dentate gyrus. Frontiers in Neural Circuits 4: 204. PDF Document: View PDF file

Yang S, Megill A, Ardiles A, Ransom S, Tran T, Koh MT, Lee H-K, Gallagher M, and Kirkwood A. (2013) Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats. Journal of Neuroscience 33 (31): 12670-12678. PDF Document: View PDF file

Megill A*, Lee T*, DiBattista AM, Song JM, Spitzer MH, Rubenshtein M, Habib LK, Capule CC, Mayer M, Turner RS, Kirkwood A, Yang J, Pak DTS, Lee H-K, and Hoe H-S. (2013) A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras mediated spinogenesis. Journal of Neuroscience 33 (22): 9306-9318. PDF Document: View PDF file

Cai X, Kallarackal AJ, Kvarta MD, Goluskin S, Gaylor K, Bailey AM, Lee H-K, Huganir RL, and Thompson SM. (2013) Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression. Nature Neuroscience 16 (4): 464-472. PDF Document: View PDF file

LeGates T, Altimus C, Wang H, Lee H-K, Yang S, Zhao H, Kirkwood A, Weber T, and Hattar S. (2012) Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature 491 (7425): 594-598. PDF Document: View PDF file

Guo Y, Huang S, de Pascuale R, McGehrin K, Lee H-K, Zhao K, and Kirkwood A. (2012) Dark exposure extends the integration window for spike-timing dependent plasticity. Journal of Neuroscience. 32 (43): 15027-15035. PDF Document: View PDF file

Wang H*, Megill A*, He K, Kirkwood A, and Lee H-K. (2012) Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity. Neural Plasticity 2012: 272374. http://www.hindawi.com/journals/np/2012/272374/

He K, Petrus E, Gammon N, and Lee H-K. (2012) Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity. Journal of Neuroscience. 32 (25): 8469-8474. PDF Document: View PDF file

Qian H, Lucas M, Zhang M, Nguyen M, Patriarchi T, Koval OM, Anderson ME, He K, Lee H-K, and Hell JW. (2012) The β2-adrenergic receptor supports prolonged theta train-induced LTP. Journal of Neurophysiology 107 (10): 2703-2712. PDF Document: View PDF file

Lee H-K. (2012) Ca2+-permeable AMPA receptors in homeostatic synaptic plasticity. Frontiers in Molecular Neuroscience 5: 17 (1-11). http://www.frontiersin.org/molecular_neuroscience/10.3389/fnmol.2012.00017/abstract

Hoe H-S, Lee H-K, and Pak DTS. (2012) The upside of APP at synapses. CNS Neuroscience & Therapeutics 18(1): 47-56. PDF Document: View PDF file

Lee H-K and Kirkwood A. (2011) AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex. Seminars in Cell and Developmental Biology 22: 514-520 PDF Document: View PDF file

He K, Goel A, Ciarkowski CE, Song L, and Lee H-K. (2011) Brain area specific regulation of synaptic AMPA receptors by phosphorylation. Communicative & Integrative Biology 4:5, 569-572. PDF Document: View PDF file

Petrus E*, Anguh TT*, Pho H, Lee A, Gammon N, and Lee H-K. (2011) Developmental switch in the polarity of experience-dependent synaptic changes in layer 6 of mouse visual cortex. Journal of Neurophysiology 106: 2499-2505. PDF Document: View PDF file

Postma F, Liu C-H, Dietsche C, Khan M, Lee H-K, Paul DL, and Kanold PO. (2011) Electrical synapses formed by Connexin36 regulate inhibition and experience-dependent plasticity. Proceedings of the National Academy of Sciences USA 108: 13770-13775. PDF Document: View PDF File

He K, Lee A, Song L, Kanold P, and Lee H-K. (2011) AMPA receptor subunit GluR1 (GluA1) serine-845 site is involved in synaptic depression but not in spine shrinkage associated with chemical long-term depression. Journal of Neurophysiology 105: 1897-1907. PDF Document: View PDF File

Goel A, Xu LW, Snyder KP, Song L, Goenaga-Vazquez Y, Megill A, Takamiya K, Huganir RL, and Lee H-K. (2011) Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity. PLoS One 6(3): e18264. Web Access

Wang H, Song L, Laird F, Wong PC, and Lee H-K. (2010) Mossy fiber long-term potentiation deficits in BACE1 knockouts can be rescued by activation of α7 nicotinic acetylcholine receptors. Journal of Neuroscience 30: 13808-13813. PDF Document: View PDF File

Gao M, Sossa K, Song L, Errington L, Cummings LW, Hwang H, Kuhl D, Worley P, and Lee H-K. (2010) A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex. Journal of Neuroscience 30: 7168-7178. PDF Document: View PDF File

Jiang B*, Huang S*, de Pasquale R, Millman D, Song L, Lee H-K, Tsumoto T, and Kirkwood A. (2010) The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period. Neuron 66: 248-259. PDF Document: View PDF File

Lee H-K, Takamiya K, He K, Song L, and Huganir RL. (2010) Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. Journal of Neurophysiology 103: 476-489. PDF Document: View PDF File

He K, Song L, Cummings LW, Goldman J, Huganir RL, and Lee H-K. (2009) Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. Proceedings of the National Academy of Sciences USA 106(47): 20033-20038. PDF Document: View PDF File

Chung HJ and Lee H-K. (2009) Constructing a road map from synapses to behavior. EMBO Reports 10 (9): 958-962. PDF Document: View PDF File

Kreczko A, Goel A, Song L, and Lee H-K. (2009) Visual deprivation decreases somatic GAD65 puncta number on layer 2/3 pyramidal neurons in mouse visual cortex. Neural Plasticity 2009: 415135. Web Access

Wang H, Song L, Laird FM, Wong PC, and Lee H-K. (2008) BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. Journal of Neuroscience 28: 8677-8681. PDF Document: View PDF File

Crombag HS, Sutton JM, Takamiya K, Lee H-K, Holland PC, Gallagher M, and Huganir RL. (2008) A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning. Behavioural Brain Research 191: 178-183. PDF Document: View PDF File

Lee H-K and Huganir RL. (2008) AMPA receptor regulation and the reversal of synaptic plasticity – LTP, LTD, depotentiation, and dedepression. In: Comprehensive Handbook of Learning and Memory (Chief Editor: J. Byrne, Volume Editor: J. D. Sweatt), Elsevier press.

Seol GH*, Ziburkus J*, Song L, Kim IT, Takamiya K, Huganir RL, Lee H-K, and Kirkwood A. (2007) Neuromodulators control the polarity of bidirectional associative plasticity. Neuron 55: 919-929. PDF Document: View PDF File

Lee H-K, Takamiya K, Kameyama K, He K, Yu S, Rossetti L, Wilen D, and Huganir RL. (2007) Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Molecular and Cellular Neuroscience 36: 86-94. PDF Document: View PDF File

Goel A and Lee H-K. (2007) Persistence of experience-induced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex. Journal of Neuroscience 27 (25): 6692-6700. PDF Document: View PDF File

Laird FM, Farah MH, Lee H-K, Savonenko AV, Price DL, and Wong PC. (2007) Beta-secretase: Physiological Role and Target Validation. In: Alzheimer’s Disease (Editors: S. S. Sisodia and R. E. Tanzi). Springer.

Goel A*, Jiang B*, Xu LW, Song L, Kirkwood A, and Lee H-K. (2006) Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience. Nature Neuroscience 9 (8): 1001-1003. PDF Document: View PDF File and PDF Document: supplementary materials

Lee H-K. (2006) Synaptic plasticity and phosphorylation. Pharmacology & Therapeutics 112: 810-832. PDF Document: View PDF File

Lee H-K. (2006) AMPA receptor phosphorylation in synaptic plasticity: Insights from knockin mice. In: The Dynamic Synapse: Molecular methods in ionotropic receptor biology (Editors: J. Kittler and S. J. Moss). CRC press.

Laird FM*, Cai H*, Savonenko AV*, Farah MH*, He K, Melnidova T, Wen H, Chiang H-C, Xu G, Koliatsos V, Borchelt DR, Price DL, Lee H-K, and Wong PC. (2005) BACE1, a major determinant of selective vulnerability of the brain to Ab amyloidogenesis, is essential for cognitive, emotional and synaptic functions. Journal of Neuroscience 25 (50): 11693-11709. PDF Document: View PDF File

Lee H-K*, Min SS*, Gallagher M, and Kirkwood A. (2005) NMDA receptor-independent long-term depression correlates with successful aging in rats. Nature Neuroscience 8 (12): 1657-1659. PDF Document: View PDF File

Hayashi ML, Choi S-Y, Rao BSS, Jung H-Y, Lee H-K, Zhang D, Chattarji S, Kirkwood A, and Tonegawa S. (2004) Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice. Neuron 42: 757-771. PDF Document: View PDF File

Lee H-K*, Takamiya K*, Han J-S, Man H, Kim C-H, Rumbaugh G, Yu S, He C, Ding L, Petralia RS, Wenthold RJ, Gallagher M, and Huganir RL. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell112: 631-643. PDF Document: View PDF File

Kim JH, Lee H-K, Takamiya K, and Huganir RL. (2003) The role of Synaptic GTPase-Activating Protein in neuronal development and synaptic plasticity. Journal of Neuroscience 23: 1119-1124. PDF Document: View PDF File

Chao SZ, Lu W, Lee H-K, Huganir RL, and Wolf ME. (2002) D1 dopamine receptor stimulation increases GluR1 phosphorylation in postnatal nucleus accumbens cultures. Journal of Neurochemistry 81: 984-992. PDF Document: View PDF File

Choi S-Y, Morales B, Lee H-K, and Kirkwood A. (2002) Long-term depression is reduced in the visual cortex of GAD65 knockout mice.Journal of Neuroscience 22: 5271-5276. PDF Document: View PDF File

Kim C-H, Chung HJ, Lee H-K, Xia J, and Huganir RL. (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proceedings of the National Academy of Sciences USA 98: 11725-11730. PDF Document: View PDF File

Lee H-K, Barbarosie M, Kameyama K, Bear MF, and Huganir RL. (2000) Regulation of distinct AMPA receptor phosphorylation sites during bi-directional synaptic plasticity. Nature 405: 955-959. PDF Document: View PDF File
Banke TG, Bowie D, Lee H-K, Huganir RL, Schousboe A, and Traynelis SF. (2000) Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase and calcineurin. Journal of Neuroscience 20: 89-102. PDF Document: View PDF File

Lee H-K and Huganir RL. (1999) Phosphorylation of glutamate receptors. In: Handbook of Experimental Pharmacology: Ionotropic Glutamate Receptors in the CNS (Editors: P. Jonas and H. Monyer). Springer-Verlag, Heidelberg.
Lee H-K*, Kameyama K*, Huganir RL, and Bear MF. (1998) NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21: 1151-1162. PDF Document: View PDF File

Kameyama K*, Lee H-K*, Bear MF, and Huganir RL. (1998) Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression. Neuron 21: 1163-1175. PDF Document: View PDF File

Kirkwood A, Lee H-K, and Bear MF. (1995) Co-regulation of long-term potentiation and experience-dependent plasticity in visual cortex by age and experience. Nature 375:328-331. PDF Document: View PDF File

Selig DK, Lee H-K, Bear MF, and Malenka RC. (1995) Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation.Journal of Neurophysiology 74 (3): 1075-1082. PDF Document: View PDF File