Investigation of the Origin of the Sequence Selectivity for the 5-Halo-2′-deoxyuridine Sensitization of DNA to Damage by UV-Irradiation. Chen, T.; Cook, G. P.; Koppisch, A. T.; Greenberg, M. M. J. Am. Chem. Soc. 2000, 122, 3861.
Independent Generation and Reactivity of 2′-Deoxy-5-methyleneuridin-5-yl, a Significant Reactive Intermediate Produced From Thymidine as a Result of Oxidative Stress. Anderson, A. S.; Hwang, J. -T.; Greenberg, M. M. J. Org. Chem. 2000, 65, 4648.
Chemical Evidence for Thiyl Radical Addition to the C6-Position of a Pyrimidine Nucleoside and its Possible Relevance to DNA Damage Amplification. Carter, K. N.; Taverner, T.; Schiesser, C. H.; Greenberg, M. M. J. Org. Chem. 2000, 65, 8375.
AlkA Protein is the Third Escherichia Coli Protein Excising a Ring Fragmentation Product of Thymine. Privezentzev, C. V.; Saparbaev, M.; Sambandam, A.; Greenberg, M. M.; Laval, J. Biochemistry 2000, 39, 14263.
Synthesis and Deprotection of Oligonucleotides Under Aprotic Conditions. Chen, T. C.; Fu, J.; Greenberg, M. M. Organic Letters 2000, 2, 3691.
Synthesis of 2′-Modified Oligodeoxynucleotides via On-Column Conjugation. Hwang, J. -T.; Greenberg, M. M. J. Org. Chem. 2001, 66, 363.
The 2-Deoxyribonolactone Lesion Produced in DNA by Neocarzinostatin and Other Damaging Agents Forms Cross-Links with the Base-Excision Repair Enzyme Endonuclease III. Hashimoto, M.; Greenberg, M. M.; Kow, Y. W.; Hwang, J.-T.; Cunningham, R. P. J. Am. Chem. Soc. 2001, 123, 3161.
Product Studies and Laser Flash Photolysis on Alkyl Radicals Containing Two Different -Leaving Groups are Consonant with the Formation of an Olefin Cation Radical. Bales, B. C.; Horner, J. H.; Huang, X.; Newcomb, M.; Crich, D.; Greenberg, M. M. J. Am. Chem. Soc. 2001, 123, 3623.
Oxygen Dependent DNA Damage Amplification Involving 5,6-Dihydrothymidin-5-yl in a Structurally Minimal System. Tallman, K. A.; Greenberg, M. M. J. Am. Chem. Soc. 2001, 123, 5181.
Observation and Elimination of N-Acetylation of Oligonucleotides Prepared Using Fast Deprotecting Phosphoramidites and Ultra-Mild Deprotection. Zhu, Q.; Delaney, M. O.; Greenberg, M. M. Bioorganic & Med. Chem. Lett. 2001, 11, 1105.
Direct Measurement of Pyrimidine C6-Hydrate Stability. Carter, K. N.; Greenberg, M. M. Bioorganic & Med. Chem. 2001, 9, 2341.
Synthesis of Oligonucleotides Containing Fapy•dG (N6-(2-Deoxy-,-D-erythro-pento-furanosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine). Haraguchi, K.; Greenberg, M. M. J. Am. Chem. Soc. 2001, 123, 8636.
Template Free Segmental Synthesis of Oligonucleotides Containing Nonnative Linkages. Greenberg, M. M.; Kahl, J. D. J. Org. Chem. 2001, 66, 7151.
Studies on N4-(2-Deoxy-D-pentofuranosyl)-4,6-diamino-5-formamidopyrimidine (Fapy•dA) and N6-(2-Deoxy-D-pentofuranosyl)- 6-diamino-5-formamido-4-hydroxypyrimidine (Fapy•dG) Greenberg, M. M.; Hantosi, Z.; Wiederholt, C. J.; Rithner, C. D. Biochemistry 2001, 40, 15856.
Repair of Oxidized Purines and Damaged Pyrimidines by E. coli Fpg Protein. Different Roles of Proline-2 and Lysine-57 Residues. Saparbaev, M.; Sidorkina, O. M.; Jurado, J.; Privezentzev, C. V.; Greenberg, M. M.; Laval, J. Environmental and Molecular Mutagenesis 2002, 39, 10.
Synthesis and Characterization of Oligodeoxynucleotides Containing Formamidopyrimidine Lesions and Nonhydrolyzable Analogues. Haraguchi, K.; Delaney, M. O.; Wiederholt, C. J.; Sambandam, A.; Hantosi, Z.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 3263.
Covalent Trapping of Human DNA Polymerase by the Oxidative DNA Lesion 2-Deoxyribonolactone. DeMott, M. S.; Beyret, E.; Bales, B. C.; Hwang, J. T.; Greenberg, M. M.; Demple, B. J. Biol. Chem. 2002, 277, 7637.
Fapy•dA Induces Nucleotide Misincorporation Translesionally by a DNA Polymerase. Delaney, M. O.; Wiederholt, C. J.; Greenberg, M. M. Angew. Chem. Int. Ed. 2002, 41, 771.
Fapy•dG Instructs Klenow Exo- to Misincorporate Deoxyadenosine. Wiederholt, C. J.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 7278.
A Minor Groove Binding Copper-Phenanthroline Conjugate Produces Direct Strand Breaks Via -Elimination of 2-Deoxyribonolactone. Bales, B. C.; Pitie, M.; Meunier, B.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 9062.
Synthesis of Oligonucleotides and Thermal Stability of Duplexes Containing the -C-Nucleoside Analogue of Fapy•dG. Delaney, M. O.; Greenberg, M. M. Chem. Res. Toxicol. 2002, 15, 1460.
Interaction of DNA Containing Fapy•dA or its C-Nucleoside Analogues with Base Excision Repair Enzymes. Implications for Mutagenesis and Enzyme Inhibition. Wiederholt, C. J.; Delaney, M. O.; Greenberg, M. M. Biochemistry 2002, 41, 15838.
Action of Human Apurinic Endonuclease (Ape1) on C1′-Oxidized Deoxyribose Damage in DNA. Xu, Y.; DeMott, M. S.; Hwang, J. T.; Greenberg, M. M.; Demple, B. DNA Repair 2003, 2, 175.
Transcription Inhibition Using Modified Pentanucleotides. Hwang, J. T.; Baltasar, F. E.; Cole, D.; Sigman, D. S.; Chen, C. B.; Greenberg, M. M. Bioorganic & Med. Chem. 2003, 11, 2321.
Cross-linking of 2-Deoxyribonolactone and its -Elimination Product by Base Excision Repair Enzymes. Kroeger, K. M.; Hashimoto, M.; Kow, Y. W.; Greenberg, M. M. Biochemistry 2003, 42, 2449.
Independent Generation and Study of 5,6-Dihydro-2′-deoxyuridin-6-yl. A Member of the Major Family of Reactive Intermediates Formed in DNA from the Effects of -Radiolysis. Carter, K. N.; Greenberg, M. M. J. Org. Chem. 2003, 68, 4275.
Synthesis of 5,12-Dioxocyclam Nickel (II) Complexes Having Quinoxaline Substituents at the 6 and 13 Positions as Potential DNA Bis-Intercalating and Cleaving Agents. Hegedus, L. S.; Greenberg, M. M.; Wendling, J. J.; Bullock, J. P. J. Org. Chem. 2003, 68, 4179.
Synthesis and Characterization of Oligonucleotides Containing the C4′-Oxidized Abasic Site Produced by Bleomycin and Other DNA Damaging Agents. Kim, J.; Gil, J. M.; Greenberg, M. M. Angew. Chem. Int. Ed. Engl. 2003, 42, 5882.
Repair of DNA Containing Fapy•dG and its -C-Nucleoside Analogue by Formamidopyrimidine DNA Glycosylase and MutY. Wiederholt, C. J.; Delaney, M. O.; Pope, M. A.; David, S. S.; Greenberg, M. M. Biochemistry 2003, 42, 9755.
Tandem Lesions are the Major Products Resulting From a Pyrimidine Nucleobase Radical. Carter, K. N.; Greenberg, M. M. J. Am. Chem. Soc. 2003, 125, 13376.
In Vitro Effects of a C4′-Oxidized Abasic Site on DNA Polymerases. Greenberg, M. M.; Weledji, Y. N.; Kroeger, K. M.; Kim, J.; Goodman, M. F. Biochemistry 2004, 43, 2656.
Mutagenic Effects of 2-Deoxyribonolactone in E. coli. An Abasic Lesion that Disobeys the A-Rule. Kroeger, K. M.; Jiang, Y.; Kow, Y. W.; Goodman, M. F.; Greenberg, M. M. Biochemistry 2004, 43, 6723.
Repair of Oxidized Abasic Sites by Exonuclease III, Endonuclease IV, and Endonuclease III. Greenberg, M. M.; Weledji, Y. N.; Kim, J.; Bales, B. C. Biochemistry 2004, 43, 8178.
Evidence for Glycosidic Bond Rotation in a Nucleobase Peroxyl Radical and its Effect on Tandem Lesion Formation. Hong, I. S.; Carter, K. N.; Greenberg, M. M. J. Org. Chem. 2004, 69, 6974.
Probing the Configurations of Formamidopyrimidines (Fapy•dA, Fapy•dG) in DNA Using Endonuclease IV. Patro, J.; Haraguchi, K.; Delaney, M. O.; Greenberg, M. M. Biochemistry 2004, 43, 13397.
Independent Generation and Characterization of a C2′-Oxidized Abasic Site in Chemically Synthesized Oligonucleotides. Kim, J.; Weledji, Y. N.; Greenberg, M. M. J. Org. Chem. 2004, 69, 6100.
Effects of the C4′-Oxidized Abasic Site on Replication in E. coli. Unusually Large Deletions are Induced by a Small Lesion. Kroeger, K. M.; Kim, J.; Goodman, M. F.; Greenberg, M. M. Biochemistry 2004, 43, 13621.
A Comprehensive Comparison of DNA Replication Past 2-Deoxyribose and its Tetrahydrofuran Analogue in E. Coli. Kroeger, K. M.; Goodman, M. F.; Greenberg, M. M. Nucleic Acids Res. 2004, 32, 5480.
In Vitro Replication and Repair of DNA Containing a C2′-Oxidized Abasic Site. Greenberg, M. M.; Weledji, Y. N.; Kroeger, K. M.; Kim, J. Biochemistry 2004, 43, 15217.
Mild Thermal Generation of 5-(2′-Deoxyuridinyl)methyl Radical From a Phenyl Selenide Precursor. Hong, I. S.; Greenberg, M. M. Org. Lett. 2004, 6, 5011.
Synthesis of Oligonucleotides Containing Fapy•dG (N-(2-Deoxy-,-D-erythropentofuranosyl)-N-(2,6-diamino-4-hydroxy-5-formamidopyrimidine)) Using a 5′-Dimethoxytrityl Dinucleotide Phosphoramidite. Jiang, Y.; Wiederholt, C. J.; Patro, J. N.; Haraguchi, K.; Greenberg, M. M. J. Org. Chem. 2005, 70, 141.
Selective Detection of 2-Deoxyribonolactone in DNA. Sato, K.; Greenberg, M. M. J. Am. Chem. Soc. 2005, 127, 2806.
Efficient DNA Interstrand Cross-Link Formation From a Nucleotide Radical. Hong, I. S.; Greenberg, M. M. J. Am. Chem. Soc. 2005, 127, 3692.
The Effect of the 2-Amino Group of 7,8-Dihydro-8-Oxo-2′-Deoxyguanosine on Translesion Synthesis and Duplex Stability. Oka, N.; Greenberg, M. M. Nucleic Acids Res. 2005, 33, 1637.
Excision of Formamidopyrimidine Lesions by Endonucleases III and VIII is Not a Major DNA Repair Pathway in E. coli. Wiederholt, C. J.; Patro, J. N.; Jiang, Y.; Haraguchi, K.; Greenberg, M. M. Nucleic Acids Res. 2005, 33, 3331.
Mechanistic Studies on DNA Damage by Minor Groove Binding Copper-Phenanthroline Conjugates. Bales, B. C.; Kodama, T.; Weledji, Y. N.; Pitié, M.; Meunier, B.; Greenberg, M. M. Nucleic Acids Res. 2005, 33, 5371.
Preparation and Analysis of Oligonucleotides Containing the C4′-Oxidized Abasic Site and Related Mechanistic Probes. Kim, J.; Kreller, C. R.; Greenberg, M. M. J. Org. Chem. 2005, 70, 8122.
DNA Interstrand Cross-link Formation Initiated by Reaction Between Singlet Oxygen and a Modified Nucleotide. Hong, I. S.; Greenberg, M. M. J. Am. Chem. Soc. 2005, 127, 10510.
Preparation and Analysis of Oligonucleotides Resulting From C5′-Oxidation. Kodama, T.; Greenberg, M. M. J. Org. Chem. 2005, 70, 9916.
Mutagenic Effects of Abasic and Oxidized Abasic Lesions in Saccharomyces cerevisiae. Kow, Y. W.; Bao, G.; Minesinger, B.; Jinks-Robertson, S.; Siede, W.; Jiang, Y. L.; Kim, J.; Greenberg, M. M. Nucleic Acids Res. 2005, 33, 6196.
Repair of Formamidopyrimidines in DNA Involves Different Glycosylases. Hu, J.; de Souza-Pinto, N. C.; Haraguchi, K.; Hogue, B. A.; Jaruga, P.; Greenberg, M. M.; Dizdaroglu, M.; Bohr, V. A. J. Biol. Chem. 2005, 280, 40544.
